key: cord-0854697-yar8a20m
authors: Gabusi, Andrea; Gissi, Davide Bartolomeo; Rossi, Roberto; Foschini, Maria Pia; Montebugnoli, Lucio
title: Persistent lesions in oral cavity after SARS‐CoV‐2 infection
date: 2021-03-01
journal: Oral Dis
DOI: 10.1111/odi.13805
sha: b5a0cc8d04a19cdec07bfdb22e6635b90a6fef20
doc_id: 854697
cord_uid: yar8a20m

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Oral lesions appeared few days after the onset of respiratory symptoms and worsened during hospitalization. However, since priority was given to therapy for SARS-COV-2-related pneumonia, oral care was delayed.

Pneumonia was treated with hydroxychloroquine, steroids, ciprofloxacin, and tocilizumab.

In April 2020, the patient was discharged from hospital but, despite apparent COVID-19 remission, he still required home oxygen therapy and no improvements of oral ulcers were experienced.

In September, a biopsy for histopathological examination was performed. Oral mucosa was ulcerated, with granulation tissue and fibrino-leukocytic material including bacterial colonies. Neither dysplasia nor fungal invasion was observed (Figure 1b) . Direct Immunofluorescence showed a non-specific deposit of fibrinogen.

Immunohistochemical search for HSV 1, HSV 2, and CMV-related proteins was negative. Sub-mucosal vessels were normal without features of vasculitis or thrombosis.

Laboratory screening tests for systemic HSV, CMV, EBV viral infections or for oral manifestations of gastrointestinal disorders were inconclusive. A marked lymphopenia (5%, 0.77 10 9 /L), excessive neutrophil count (88%, 11.3 10 9 /L), and high ferritin values (1,485 ng/ml) were recorded.

Therapeutic attempts to relief patient's painful condition with topical betamethasone, Chlorhexidine gel, and topical lidocaine were unable to achieve improvements in pain reduction.

Finally, in October acute respiratory conditions worsened, patient refused a new hospitalization and in November 2020 died of respiratory failure.

The suspicion that oral lesions could be related to SARS-COV-2 infection was raised.

which is abundant in mucosa cells of the oral cavity (Xu et al., 2020) .

It has been speculated that oral tissues might thus provide not only a possible route of entry for the SARS-COV-2 but also an extrapulmonary target. Unlike previous cases, in our patient, ulcerative lesions were associated with persistent immunological impairment and did not heal after SARS-COV-2 eradication. Noteworthy, lymphopenia and neutrophilia have been described by many authors as a predictor of severity and poor prognosis in COVID-19 older patients Wang et al., 2020; Ye et al., 2020) .

It may be speculated that non-healing oral ulcerations may represent a sign of a persisting immunological storm-related damage after SARS-COV-2 eradication.

The present case, in agreement with emerging research, highlights the relevance of oral examination in proved or suspected F I G U R E 1 (a) Painful ulcerated plaque of the mucosal side of the inferior lip. Similar lesions affected both margins of the tongue, both lips, and soft palate. (b) At low power, the oral mucosa was ulcerated with granulation tissue and fibrino-leukocytic material including bacterial colonies. Dense inflammatory infiltrate was present in the submucosa (a) (b)

Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations?

Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. Clinical Infectious Diseases. Epub ahead of print

Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation

Persistent lesions in oral cavity after SARS-CoV-2 infection