key: cord-0851706-725l0a3u
authors: Ng Cheong Chung, Kenneth Jordan
title: The frailty and mortality relationship in patients with COVID-19
date: 2021-01-03
journal: Eur Geriatr Med
DOI: 10.1007/s41999-020-00391-2
sha: 695e7e19c6ef116d1b73cf98261537495dcfa338
doc_id: 851706
cord_uid: 725l0a3u

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Second, the authors suggest that frailty on the CFS is not associated with increased mortality. Previous studies have shown that there exist an association between frailty on the CFS and mortality in older inpatients with COVID-19 [4] . More specifically, the CFS has been shown to be a useful tool for risk stratification in patients with COVID-19 and has been shown to better predict disease outcomes than age and comorbidity [2] . This highlights the importance of treating their findings with caution and encouraging further research on this relationship. Third, they also show an inverse relationship between CRP and frailty measured on the CFS. Although the relationship between frailty and inflammation is poorly understood, the literature suggests frailty and pre-frailty are associated with higher inflammatory parameters with frail and pre-frail patients having significantly higher serum levels of CRP and IL-6 than robust patients [5] . Perhaps adjustment for factors exhibiting worsening clinical outcome with increasing frailty, including CRP, are required to find the true association between frailty and increased mortality as previously described [2] .

Author contributions KJNCC contributed to writing and drafting the article.

Funding None.

Data availability Not applicable. 

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The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study

Black, Asian and Minority Ethnic groups in England are at increased risk of death from COVID-19: indirect standardisation of NHS mortality data

Association of frailty with mortality in older inpatients with Covid-19: a cohort study

Inflammation and frailty in the elderly: a systematic review and meta-analysis