key: cord-0850601-3rk4uhqb
authors: Calcaterra, Giuseppe; Bassareo, Pier Paolo; Mehta, Jawahar L.
title: Letter in response to “COVID‐19, Virchow's triad and thromboembolic risk in obese pregnant women”
date: 2021-03-24
journal: Clin Cardiol
DOI: 10.1002/clc.23601
sha: b9b0b5add9e708b8d52cc3467a049f63c82022ed
doc_id: 850601
cord_uid: 3rk4uhqb

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Letter in response to "COVID-19, Virchow's triad and thromboembolic risk in obese pregnant women"

To the Editor We appreciate very much the letter by Carbillon virus induces an overwhelming "inflammatory state." Further, the virus induces endothelial dysfunction by creating a state of "endothelialitis." As the French authors say "the gravid uterus mechanically compresses veins as its volume increases, while the action of progesterone induces a loss of tone of the vein wall, and these factors combine their effect to slow blood flows when the patient is hospitalized and immobilized." 1, 4 Maternal obesity has emerged as a key risk factor increasing susceptibility of pregnant women to severe COVID-19 disease, and most authors have recommended thromboprophylaxis in all obese women hospitalized with COVID-19. The risk-benefit ratio is in favor of anticoagulant prophylaxis, as soon as the diagnosis of COVID-19 has been made. It appears to be a sound practice in clinical practice. 5 Obesity rates among pregnant women have increased drastically worldwide over the last three decades. 6 The risk of moms-to-be passing the virus to the fetus is a "still evolving" area of research. Fortunately, a vertical transmission to the fetus is rare due the absence of ACE receptors on the placenta. 7

The authors declare no potential conflict of interest. 

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