key: cord-0850093-vi5l9sbq
authors: Martins, S.; Ferreira, A.R.; Fernandes, J.; Vieira, T.; Fontes, L.; Coimbra, I.; Paiva, J.A.; Fernandes, L.
title: P.0811 Factors and outcomes associated with delirium in critically ill COVID-19 patients
date: 2021-12-30
journal: Eur Neuropsychopharmacol
DOI: 10.1016/j.euroneuro.2021.10.671
sha: d475c718c612e277365e9e462d7515c6a3cc8b13
doc_id: 850093
cord_uid: vi5l9sbq

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, with rates up to 65% in critically ill patients [3] . Several potential reasons, including the use of deep sedation and invasive mechanical ventilation (IMV), as well as the restrictions to limit infection transmission, such as prohibition of family visits and minimal contact with health staff were identified [4] . Although factors and outcomes associated with delirium are well documented, limited data are available regarding severe COVID-19 patients. Aims: This study aims to estimate the rates of delirium in critically ill COVID-19 patients and to analyze factors that may be associated with its development, as well as to examine long-term outcomes.

Introduction: Prophylactic cranial irradiation (PCI) is part of the standard treatment for patients with small cell lung cancer (SCLC) given that it reduces the incidence of brain metastases and improves overall survival by up to 2-fold. While this intervention implies unwanted effects, namely cognitive decline, recent evidence has shown that memantine and hippocampal-avoiding brain radiotherapy improve the cognitive profile after therapeutic brain radiotherapy. We performed a real-life single-center study with the combined use of both therapeutical approaches in patients with SCLC receiving PCI. Furthermore, we explored if the volumes of specific brain structures at baseline selected based on the available literature were predictive of the cognitive impact of brain radiotherapy. Methods: Patients with SCLC were identified consecutively at the Champalimaud Clinical Centre between June 2014 and June 2019 and followed prospectively as a cohort. Patients underwent a daily regimen of memantine starting prior to irradiation and both hippocampi were spared during radiotherapy. Primary analyses evaluated the change of several neuropsychological measurements across time, up until 6 months after the last session of radiotherapy. All patients underwent brain imaging as part of staging before PCI. If 3D T1-weighted volumes were available from baseline MRI, automated segmentation was performed using Freesurfer v6.0

Nonsuicidal Selfinjury: A Systematic Review

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Why Do People Hurt Themselves? A New Conceptual Model of Nonsuicidal Self-Injury

Solving the puzzle of deliberate self-harm: The experiential avoidance model

Psychological inflexibility in childhood and adolescence: Development and evaluation of the Avoidance and Fusion Questionnaire for Youth

ISARIC4C investigators, 2020. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Delirium and adverse outcomes in hospitalized patients with COVID-19

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COVID-19: ICU delirium management during SARS-CoV-2 pandemic

Lisboa, Portugal; 2 Champalimaud Clinical Centre-Champalimaud Centre for the Unknown, Department of Radiology