key: cord-0849383-i64y5x1j
authors: Kissling, Sébastien; Rotman, Samuel; Fakhouri, Fadi
title: Visualization of putative coronavirus in kidney
date: 2020-05-08
journal: Kidney Int
DOI: 10.1016/j.kint.2020.05.002
sha: db6e3e215472ed484f3c00a5ba0bef5ae26a3e25
doc_id: 849383
cord_uid: i64y5x1j

nan

We thank Drs Miller and Brealey for their comments and fully acknowledge their expertise in the field of electron microscopy. We also acknowledge our uncertainties regarding the exact nature of the particles seen in the podocytes in our patient's kidney biopsy and we were cautious in the interpretation of these findings. Following Drs Miller and Brealey's comments, we have modified our letter before its final publication in the journal to further underline that these particles may correspond to non-viral entities.

However, the particles detected in our patient's biopsy are rather similar to the ones reported in the first documentation of SARS-CoV-2 1 . Besides, the appearance of intra-cellular viral inclusions appears to be quite variable from one publication to another 2,3 . To our opinion, it remains therefore possible that the particles observed in our patient are of viral origin. Nevertheless, we totally agree with Drs Miller and Brealey that the definite proof for the presence of viral inclusions in cells requires an immunostaining with specific antibodies, whether in cultured cells or in tissue samples.

Our knowledge of COVID-19 is rapidly evolving and caution is of the utmost importance.

Sébastien Kissling 1 , Samuel Rotman 2 and Fadi Fakhouri 1 .

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