key: cord-0849336-vrlkxc96
authors: Lospinoso, Kristen; Nichols, Camerson S.; Malachowski, Stephen J.; Mochel, Mark C.; Nutan, Fnu
title: A Case of Severe Cutaneous Adverse Reaction Following Administration of the Janssen Ad26.COV2.S COVID-19 Vaccine
date: 2021-05-26
journal: JAAD Case Rep
DOI: 10.1016/j.jdcr.2021.05.010
sha: a7755aaa27c865e4e748be4cca0262459e4f6ef3
doc_id: 849336
cord_uid: vrlkxc96

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or medication changes prior to onset. Of note, he took prednisone 5 mg daily for adrenal 58 insufficiency, but his community dermatologist increased this to 20 mg daily for a suspected stasis 59 dermatitis flare when this eruption was mostly on his lower extremities. 60

Physical exam revealed a generalized distribution (50% body surface area) of erythematous 61 plaques, studded with numerous small, non-follicular pustules (Figure 1 ). The rash spared the face, 62 genitals, and mucosae. There was significant acral swelling, but no palpable lymphadenopathy. 63

Labs at presentation (t+13) were notable for an elevated white blood cell count composed of 64 absolute neutrophilia and an elevated eosinophil count (Table 1) (Figure 1) , markedly reduced density, and decreased 106 intensity, of erythematous plaques on the torso and extremities (A&B). Improving lower extremity 107 edema is also seen (B) but not pictured in Figure 1 . 108 Table 1 : Results of main diagnostic workup during admission. Generally benign with exception of 109 neutrophilia and eosinophil count that later increased by a factor of three (not shown). 

The Johnson & Johnson Vaccine 126 for COVID-19

Public needs to prep for vaccine side effects

COVID arm": 129 A reaction to the Moderna vaccine

Morbilliform rash after administration of Pfizer-BioNTech 131 COVID-19 mRNA vaccine

Severe 133 cutaneous adverse reactions to drugs

Cutaneous reactions to vaccinations

Immune-137 mediated adverse reactions to vaccines

Comparison of Diagnostic Criteria and Determination of 140

Prognostic Factors for Drug Reaction With Eosinophilia and Systemic Symptoms 141 Syndrome

Acute generalized exanthematous pustulosis 143 (AGEP): A review and update

 Table 1 : Results of main diagnostic workup during admission. Generally benign with exception of neutrophilia and eosinophil count that later increased by a factor of three (not shown). Electrocardiogram was within normal limits. Blood