key: cord-0848368-986xo242 authors: Cuneo, Ami Z.; Maisha, Kazi; Minen, Mia T. title: Strategies for Behavioral Research in Neurology: Lessons Learned During the COVID-19 Pandemic and Applications for the Future date: 2021-10-27 journal: Curr Neurol Neurosci Rep DOI: 10.1007/s11910-021-01146-7 sha: 222ea0396dc576fc7a5cb50b30c42faee440487a doc_id: 848368 cord_uid: 986xo242 PURPOSE OF REVIEW: Behavioral therapies are proven treatments for many neurologic conditions. However, the COVID-19 pandemic has posed significant challenges for conducting behavioral research. This article aims to (1) highlight the challenges of running behavioral clinical trials during the pandemic, (2) suggest approaches to maximize generalizability of pandemic-era studies, and (3) offer strategies for successful behavioral trials beyond the pandemic. RECENT FINDINGS: Thousands of clinical trials have been impacted by the COVID-19 pandemic, from undergoing protocol revisions to suspension altogether. Furthermore, for ongoing trials, recruitment of diverse populations has suffered, thereby exacerbating existing inequities in clinical research. Patient adherence and retention have been affected by a myriad of pandemic-era restraints, and medical, psychiatric, and other complications from the pandemic have the potential to have long-term effects on pandemic-era study results. SUMMARY: In the development of post-pandemic study protocols, attention should be given to designing studies that incorporate successful aspects of pre-pandemic and pandemic-era strategies to (1) broaden recruitment using new techniques, (2) improve access for diverse populations, (3) expand protocols to include virtual and in-person participation, and (4) increase patient adherence and retention. Behavioral therapies, such as biofeedback, cognitive behavioral therapy (CBT), and relaxation techniques, are proven, non-pharmacologic treatments for a range of neurologic conditions. They offer benefit in individuals with headache, multiple sclerosis, epilepsy, and Parkinson's disease [1] [2] [3] [4] [5] . In related conditions, such as chronic pain, insomnia, and psychiatric disorders, a meta-analysis demonstrated that CBT alone had higher response rates than comparison conditions [6] . Clinically, behavioral therapies offer several advantages: They benefit a wide spectrum of patients, from children, to adults, to older populations [1, 7, 8] ; they may be used as add-on therapies to standard medical treatments [1] ; and additionally, they may provide successful monotherapy for individuals who are unable to undergo pharmacologic treatment, or for those disinclined toward typical medical therapies [1, 9, 10] . The high efficacy and wide-reaching potential of behavioral strategies underscores the importance of rigorous clinical trials to further establish therapeutic behavioral approaches. However, participation in behavioral clinical trials is often low due to participants' lack of knowledge about these therapies, negative beliefs about behavioral treatments, decreased motivation or support for new therapies, and poor self-efficacy [11] [12] [13] . This behavioral research conundrum has been further exacerbated by the COVID-19 pandemic, which has hindered or halted more than 20,000 clinical trials, affecting approximately 80% of non-COVID-related studies worldwide [14, 15•] . Of the ongoing trials during the pandemic, behavioral studies arguably have been disproportionately This article is part of the Topical Collection on Behavior * Ami Z. Cuneo amiza@uw.edu impacted by social distancing guidelines, as behavioral studies often involve face-to-face interaction for delivery of a therapeutic intervention. Furthermore, the pandemic's reduction in sheer number of clinical trials may disproportionally affect vulnerable patient populations [16] . Therefore, the authors suggest adopting strategies learned from the COVID-19 pandemic into current behavioral research practices both to avoid disruption in research in the future and to take advantage of successes devised during the pandemic. Based on the authors' behavioral clinical research experiences during the COVID-19 pandemic and upon literature review, this article aims to (1) highlight the challenges of running behavioral clinical trials during the pandemic, (2) suggest approaches to maximize generalizability of pandemic-era studies, and (3) offer strategies for successful behavioral trials beyond the pandemic. Challenges During the pandemic, studies were affected by a range of institution-specific aspects of the Institutional Review Board (IRB) approval process. Many IRBs recommended human subject trials be conducted remotely to reduce the spread of the COVID-19 virus [15•] . Institutions, such as Columbia University, University of Michigan at Ann Arbor, Harvard University, and the California Institute of Technology, suspended (with limited exceptions) in-person human subjects research [17] . The inability to shift appropriately to virtual alternatives of in-person research contributed to the halting of many behavioral trials [18••] . Given the emphasis on in-person interactions in behavioral studies, these trials were at increased risk of being impacted. In the development of post-pandemic studies, attention should be given to implementing protocols that allow for flexibility in offering both in-person and virtual options for face-to-face interactions (e.g., virtual interviews and behavioral interventions, online and/or telephone-based surveys). Study designs should allow for flexibility in visits (virtual and in-person) without requiring IRB protocol modification [19 •] . To limit in-person interactions, researchers should consider electronic distribution of study materials (e.g., email or text messages) or postal service delivery to trial participants. Extra time should be allotted to the study protocol in case of delays in research. Research teams should become familiar with their IRB's updated, post-pandemic support systems, such as (1) educational and training sessions for investigators regarding updated IRB parameters, (2) expanded IRB virtual office hours, and (3) increased email news updates [19• ]. Challenges For years, trials in neurology have struggled to include underrepresented populations [20, 21, 22 ••, 23••], resulting in diverse groups receiving decreased access to therapies offered in studies, as well as limiting the medical field's ability to interpret study results [24] . The pandemic further impacted study recruitment, as traditional routes (e.g., flyers, brochures, and word of mouth, and routine inperson clinical visits) were affected by stay-at-home orders and social distancing [25] . Strategies Telemedicine visits surged during the pandemic, with some neurology practices experiencing at least a 500% increase in virtual operations [26•] . The ability of the medical field to adapt to such changes demonstrates promise in new and virtual enrollment methods. Post-pandemic strategies include expanded use of digital health platforms for participant recruitment [27••] and integration of recruitment into existing clinic telehealth structures. For example, at the completion of a patient visit, a research study team member may join the telehealth visit remotely to facilitate rapid recruitment (i.e., to explain the study, confirm eligibility, and expedite consent for those interested). Furthermore, as the field aims to expand clinical trial enrollment of underrepresented and/or vulnerable populations to improve public health inequities [28•, 29, 30] , social media advertisements have emerged as a powerful tool [27••, 31•] . The benefit of recruitment through social media has additional advantages: in one clinical trial on Parkinson's disease, recruitment via social media resulted in quicker and more cost-effective enrollment than even mass media techniques [32] . Therefore, public networks should be considered for the optimization of patient recruitment and enrollment, as in Table 1 . Social media methods may include (1) advertising on Google, Facebook, and YouTube with web links to the clinical trial website; (2) implementing a Twitter campaign to raise research awareness; and (3) collaborating with online advocacy/peer-support groups related to the research topic (e.g., Parkinson's disease support groups). Challenges The COVID-19 pandemic has variably impacted lives of many. Essential workers, parents, and others may have more demanding schedules, rendering them unable to participate in studies. Others have lost employment or no longer commute to work, resulting in perhaps more free time and interest in free access to behavioral therapies. Others who are less technologically savvy may have less interest in technology-focused studies. Patients with pre-existing health conditions may avoid in-person interactions during the pandemic. As a result, the demographics of individuals interested and able to participate in pandemic-era behavioral research may be skewed. During the pandemic, a Pew Research Center survey of more than 5000 US full-time and part-time workers showed that most teleworkers had increased flexibility in their schedules since the start of the pandemic [33] . Although clinical research may benefit from participants with increased control over their schedules, attention to increasing diversity of recruitment is warranted. In addition, as clinical trials expand to include remote platforms, there is risk of further slanting a recruited population toward individuals who own digital tools and/or have the technical abilities to use them [15•] . One study revealed a stark digital divide in the nation: As of June 2021, about a quarter of adults with incomes below $30,000 a year did not own a smartphone; 43% did not have home broadband services; 41% did not have a computer [34] . Racial/ethnic minority community members may also be excluded disproportionately from studies, as Black and Hispanic Americans lag behind Caucasian Americans in internet adoption even after controlling for income [35•] . Therefore, relying exclusively on digital/virtual study recruitment and protocols risks exclusion of those of lower socioeconomic status and minorities. Strategies When planning study protocols, consider minimizing the time commitment required for the study and favor home-based behavioral treatments. Choose technologies (e.g., headache diary applications) with which patients may already be familiar. To ensure demographic transparency in virtual studies, published protocol reports should include detailed demographic information [36] to clarify how interventions may impact those of many cultures and ethnicities. To improve inclusion rates of participants from wide range of economic statuses in virtual era studies, efforts should be made to provide temporary internet access and digital devices to low-income participants (e.g., purchasing mobile hotspots for participants). These efforts are relevant both during the pandemic and beyond, particularly as the field aims to improve equity across all arenas [36] . Challenges A range of psychological factors, such as lack of motivation, negative attitudes and beliefs, poor awareness of triggers, external locus of control, poor self-efficacy, low levels of acceptance, and engagement in maladaptive coping styles, have been observed to contribute to nonadherence in neurologic behavioral trials [11] [12] [13] . The pandemic arguably may have increased nonadherence rates, as influences of pandemic-related psychological changes (e.g., increased depression and anxiety) may affect patient motivation [37] . Limited in-person interactions also may contribute to decreased adherence, as communication and good rapport between researchers and participants are integral to patient retention, especially in underrepresented and/or vulnerable groups [38] . Poor adherence may contribute to inadequate participant retention, an established barrier to completing behavioral clinical trials in neurology [39] . Strategies Devise strategies to bolster patient adherence and retention. Establish rapport with study participants early on; consider initial virtual or telephone meetings with the study coordinator to further engage participants. Ensure participants are aware of several methods through which they can contact the study coordinator (e.g., telephone, text, email, or virtual platforms) during defined on-call hours. Request permission from patients to text and/or email reminders to complete behavioral therapies. Provide participants with electronic "study news" updates. Consider incorporating additional behavioral modifications, such as motivational interviewing and/or principles of behavioral economics to help with engagement. Challenges Conducting behavioral research during a pandemic raises concerns about generalizability of results to a non-pandemic era. In particular, the COVID-19 pandemic saw an increase in mood symptoms in the general population [37, 40] . In neurologic conditions, such as headache, comorbidities including stress, anxiety, and depression have a bidirectional relationship [41] ; at the same time, therapeutic behavioral approaches used for headache also may impact mood [42 •] . Therefore, pandemic-era behavioral study results may be dually confounded [43•, 44] . Furthermore, the neurological manifestations of COVID-19 (e.g., dizziness, headache, myalgias, hypogeusia, hyposmia) may overlap with the neurologic symptoms assessed in behavioral trials, affecting study results [44] . Certain medical comorbidities associated with COVID-19, including the consequences of stay-at-home orders (e.g., decreased physical activity) and the long-term effects of the COVID-19 itself in some participants, may impact study results. Therefore, caution must be taken when analyzing and interpreting results of pandemic-era behavioral studies. To increase generalizability to a non-pandemic era, incorporate measures to evaluate for mood-and anxiety-related comorbidities into statistical analysis. Consider studying behavioral approaches that are novel and interesting to the patient, so that patients will be engaged with therapy in both pandemic and non-pandemic times. Use behavioral techniques that are complementary to usual healthcare. Throughout the study, teach methods to incorporate behavioral strategies into patients' daily routines. Reinforce the clinical benefits with patients during the pandemic and thereafter. The COVID-19 pandemic has influenced behavioral research in a myriad of ways, and ultimately, the pandemic's impact will be determined over time. However, the constraints of the pandemic encourage application of creative approaches to both study design and to the development of methods to improve participant recruitment, adherence, and retention, and generalizability of results in behavioral trials. In particular, innovation in study design should be continued post-pandemic to optimize research while maintaining both in-person and virtual options for patients, as needed. Patient recruitment and retention strategies, including less traditional digital approaches, should be pursued to ensure enrollment of diverse patient populations, and to improve adherence and retention in studies. Focus groups may be performed to analyze patients' experiences in trials during and post-pandemic. As these strategies are integrated, more research is needed to devise methods to protect clinical trials from pandemic-related or other disruptions in the future. Overall, the pandemic has created an opportunity for researchers and clinicians to re-evaluate the established norms of clinical behavioral research, and to take a leap forward, merging the most effective aspects of pre-pandemicand pandemic-era studies. These new approaches may be applied both during the pandemic and beyond. Conflict of Interest Ami Cuneo and Kazi Maisha each declare no potential conflict of interest. Mia Minen has received a grant from the National Institute of Health and contributed to developing intellectual property being used in this study that is co-owned by NYU and IRODY. If the research is successful, NYU and IRODY may benefit from the outcome. This article does not contain any studies with human or animal subjects performed by any of the authors. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology Cognitive behavioral therapies and multiple sclerosis fatigue: a review of literature Cochrane systematic review and metaanalysis of the impact of psychological treatments for people with epilepsy on health-related quality of life Cognitive-behavioural therapy for non-motor symptoms of Parkinson's disease: a clinical review Telephone-based cognitive behavioral therapy for depression in Parkinson disease: a randomized controlled trial The efficacy of cognitive behavioral therapy: a review of meta-analyses Efficacy of cognitive behavioral therapy for anxiety disorders in older people: a metaanalysis and meta-regression of randomized controlled trials Efficacy of exposure-based cognitive behavioral therapy for youth anxiety and obsessive-compulsive disorder. Exposure therapy for children with anxiety and OCD Efficacy of digital cognitive behavioral therapy for the treatment of insomnia symptoms among pregnant women: a randomized clinical trial Key Potentially Inappropriate Drugs in Pediatrics: the KIDs List Barriers to behavioral treatment adherence for headache: an examination of attitudes, beliefs, and psychiatric factors Focus group findings on the migraine patient experience during research studies and ideas for future investigations Underuse of behavioral treatments for headache: a narrative review examining societal and cultural factors COVID-19 and readjusting clinical trials. The Lancet This paper detailed how the pandemic negatively affected many active non-COVID clinical trials by halting or terminating them Improving clinical trial enrollment-in the Covid-19 era and beyond As coronavirus spreads, universities stall their research to keep human subjects safe. The Chronicle of Higher Education Clinical research during the COVID-19 pandemic: the role of virtual visits and digital approaches Implications to IRB operations due to the COVID-19 pandemic Barriers and facilitators of African American participation in Alzheimer disease biomarker research Partnering with Middle Eastern/Arab American and Latino Immigrant Communities to Increase Participation in Alzheimer's Disease Research This paper acknowledged the existing challenge in including underrepresented groups in headache medicine research and revealed methods to increase participation in those groups Factors associated with, and mitigation strategies for, healthcare disparities faced by patients with headache disorders. Neurology 2021. (This paper addressed the inequities faced by underrepresented groups in headache medicine and provided strategies to solve disparities in the management of headache medicine Recruitment and retention monitoring: facilitating the mission of the National Institute of Neurological Disorders and Stroke (NINDS) The Physician's Foundation. The Physicians Foundation 2020 Physician Survey: Part 1 Teleneurology as a solution for outpatient care during the COVID-19 pandemic This article emphasized the beneficial role of social media in patient recruitment to clinical trials This article outlined solutions to maintain active clinical trials in the pandemic and highlighted the importance of continuing trials, as their suspension has led to an increase in off-trial and off-label use of medication Needs, priorities, and recommendations for engaging underrepresented populations in clinical research: a community perspective Engaging African American women in research: an approach to eliminate health disparities in the African American community Social media as a recruitment platform for a nationwide online survey of COVID-19 knowledge, beliefs, and practices in the United States: methodology and feasibility analysis Strategizing clinical trial recruitment in the digital age How the coronavirus outbreak has -and hasn't -changed the way Americans work Digital divide persists even as Americans with lower incomes make gains in tech adoption No participant left behind: conducting science during COVID-19 Abstract TP409: reporting of key demographic characteristics in neurological trials registered on ClinicalTrials. gov Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey Lessons learned recruiting a diverse sample of rural study participants during the COVID-19 pandemic Determinants of dropout and nonadherence in a dementia prevention randomized controlled trial: the prevention of dementia by intensive vascular care trial Migraine and its psychiatric comorbidities This paper examined the bidirectional relationship between mood and migraines in children and proposed interventions to improve the quality of life in children with migraines Conducting clinical research during the COVID-19 pandemic: protecting scientific integrity Neurological manifestations and implications of COVID-19 pandemic Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.