key: cord-0848029-0ixayms1
authors: Kumar, Pramod; Sharma, Mithun; Kulkarni, Anand; Rao, Padaki Nagaraja
title: Pathogenesis of Liver injury in COVID-19
date: 2020-05-20
journal: J Clin Exp Hepatol
DOI: 10.1016/j.jceh.2020.05.006
sha: 8541d3fb1892ad53717a134548f1094d9a9fbcf5
doc_id: 848029
cord_uid: 0ixayms1

nan

disease 2019 (COVID-19) 1 . The precise mechanism of liver injury is still unclear. These abnormalities could be due to virus-related cytopathic effects or non-viral causes such as cytokine storm, hypoxia, and hepatotoxic medications 2 . (Figure 1 ) There are no peer-reviewed published research articles on the pathogenesis of liver injury, and the pandemic has led to an unprecedented surge in preprint publications on Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We sought relevant scientific studies regarding liver injury by SARS-CoV-2 virus in four public preprint repositories [i.e., medRxiv, bioRxiv, arXiv, and Social Science Research Network In summary, the preliminary studies suggest that the strong predilection for cholangiocyte infection and consequently impaired liver regeneration might be responsible for liver injury in COVID-19.

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Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids