key: cord-0843957-5qfciqms
authors: Haq, Afrozul; Anderson, Paul H.; Fleet, James C.; Razzaque, Mohammed S.
title: Viral infections and Vitamin D: relevance to COVID-19 pandemic
date: 2022-04-27
journal: J Steroid Biochem Mol Biol
DOI: 10.1016/j.jsbmb.2022.106119
sha: 0c2360fcb4cbd2665aa9ad8465f7b3879d70ad91
doc_id: 843957
cord_uid: 5qfciqms

nan

Afrozul Haq (1), Paul H. Anderson (2) , James C. Fleet (3), Mohammed S.

Razzaque (4) (1) H. A. University, Imphal, Manipur, India;

(2) (2) Clinical and Health Sciences, Health and Biomedical Innovation, University of South Australia, Australia;

(3) (3) Department of Nutrition Science, Purdue University, West Lafayette, USA;

(4) (4) Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, USA find an answer to the lack of specific treatment. Reportedly, the pathophysiology of the disease is marked by worsened inflammation due to weakened immunity which leads to infiltration of immune cells and necrosis.

This causes a drastic drop in the pulmonary oxygen exchange due to hyperplasia of the lungs, which manifests as severe pneumonia, causing fatalities. Importantly, SARS-CoV2 infection also causes fatalities due to viral septic shock, which results from uncontrolled and backfired immune reactions to the pathogen. As Vitamin D and its derivatives have been shown to enhance immunity against respiratory illnesses, this comprehensive presentation certainly delineates the plausibility of employing it as a preventive and therapeutic agent against the current and future pandemic from an immunological perspective.

In this editorial, we would like to briefly describe the role of Vitamin D pathway is necessary to understand how they influence the course of many human diseases. (2) 

The relevance of vitamin D in the oral health of HIV infected patients

Vitamin D receptor expression in mature osteoclasts reduces bone loss due to low dietary calcium intake in male mice