key: cord-0841486-cwpmrro3
authors: Di Giuseppe, Gabriella; Pelullo, Concetta P.; Lanzano, Raffaele; Napolitano, Francesco; Pavia, Maria
title: Knowledge, attitudes, and behavior of incarcerated people regarding COVID-19 and related vaccination: a survey in Italy
date: 2022-01-19
journal: Sci Rep
DOI: 10.1038/s41598-022-04919-3
sha: 1618dc22f60249524565c23f388fbed657ca7f4e
doc_id: 841486
cord_uid: cwpmrro3

The cross-sectional study assessed knowledge, attitudes, and preventive practices toward COVID-19 disease of incarcerated people. A total of 685 subjects were surveyed. 94% were aware that respiratory droplets are involved in the transmission of COVID-19, and 77.2% that patients with chronic conditions are at risk of a more severe disease. Overall, 92.7% of respondents considered COVID-19 a more severe disease compared to influenza, and 85.4% believed that COVID-19 could cause serious consequences in their institution. Only 22.6% were self-confident about their ability to protect themselves from SARS-CoV-2 infection. This attitude was significantly higher in those who were involved in working activities in the institution, who did not report at least one common symptom compatible with COVID-19 in the previous 3 months, who did not show generalized anxiety symptoms, and did not need additional information. 63.9% of incarcerated people expressed willingness to receive COVID-19 vaccination. Older subjects, who knew that a COVID-19 vaccination is available, believed that COVID-19 is more serious than influenza, and were self-confident about their ability to protect themselves from SARS-CoV-2 infection, were significantly more willing to undergo COVID-19 vaccination. Public health response to COVID-19 in prisons should address vaccine hesitancy to increase vaccine confidence among incarcerated people.

subjects who were approached for the study, 165 refused to reply to the questionnaire because they did not consider the investigation useful to improve their health condition and 685 agreed to participate, with a participation rate of 80.6%. The main characteristics of the study population are reported in Table 1 . The participants were between 18 and 78 years old (mean 42.4) , almost all were Italian, only 25.8% had obtained a high school or university degree, 60% were married, 76.2% had sons/daughters, and slightly more than half (53.3%) were employed before detention. The vast majority (92.7%) lived in shared cells, for 41.4% this was the first episode of incarceration, and 28.6% reported a working activity in the prison. Moreover, 26.7% of the respondents were affected by chronic diseases, 62.3% reported at least one common symptom compatible with COVID-19 in the previous 3 months, and 86.7% had undergone a screening test with RT-PCR for SARS-CoV-2 detection.

Knowledge about COVID-19 and related prevention. Overall, 94% of incarcerated people knew that respiratory droplets are involved in the transmission of COVID- 19, 93 .1% that COVID-19 can be transmitted by touching the mouth, nose and eyes with contaminated hands, and 77.2% that patients with chronic conditions are at risk of a more severe disease. Regarding prevention, 80.3% knew that a COVID-19 vaccine is available, and 96.6%, 95.6% and 95.2% mentioned hand washing, face masks use and physical distancing as effective infection control measures for COVID-19, respectively. Moreover, 19 .6% knew the effective infection control measures for COVID-19 (Table 2 ).

Attitudes about COVID-19 and related prevention. Severity of the disease was perceived by 92.7% of respondents who agreed that COVID-19 is more serious than influenza, by 85.4% who believed that this disease could cause serious consequences in their institution, by 82.3% who perceived to be at high risk of severe complications caused by COVID-19, and by 62.8% who believed that COVID-19 will continue to spread in Italy. Moreover, 38.7% considered themselves to be at risk of developing COVID-19, 32.5% believed that, even if necessary, they would prefer avoiding to go to the hospital due to the fear of contracting COVID-19, whereas only 22.6% were self-confident about their ability to protect themselves from SARS-CoV-2 infection (Table 3) .

More than half (51.7%) and almost half (45.3%) were screened positive for symptoms of generalized anxiety and depression, respectively. Almost two thirds of the participants (63.9%) expressed willingness to receive COVID-19 vaccination and the most commonly reported reasons were the reduction of risk of infection (64.7%), the effectiveness (48.9%) and safety (48.2%) of the vaccine, that they believed themselves at high-risk of developing COVID-19 (47%), whereas only 19.2% reported that it had been recommended by a physician. For incarcerated who declared their unwillingness to receive a future COVID-19 vaccination, the main barriers were the concern about the safety (64.7%) and effectiveness (27.6%) of the vaccine, 25.4% believed it was not useful, and 22.4% reported that it was not recommended by a physician. The willingness to receive COVID-19 vaccination according to the socio-demographic and anamnestic characteristics, knowledge, and attitudes about COVID-19 of incarcerated is reported in Tables 1, 2 and 3. Behaviors related to COVID-19 prevention. Practice of protective behaviors was reported by 83.6% of participants who declared that they used face masks when they were seen by a doctor, or when they left the cell during working hours (84.7%) or yard time (80.3%). The majority of the respondents wash/disinfect their hands during yard time (81.9%), when they leave the cell during working hours (79.7%), and when they were seen by a doctor (71%). Moreover, 81.3% and 79.3% declared to practice hand washing before eating and after using the bathroom, respectively.

Almost two thirds of the participants (67%) reported to have modified their habits, in the 3 months preceding the survey, as a consequence of fear of contracting COVID-19, and the most commonly reported behaviors were avoiding close contacts (12.7%), gatherings (11.1%), socialization with other people in prison (10.5%), and practicing physical distancing (7%). Moreover, more than half (51.6%) expressed intention to avoid some behaviors in the next days for fear of contracting COVID-19, such as gatherings (11%), close contacts (9.9%), socialization with other incarcerated people (7.4%), and practice some preventive behaviors such as physical distancing (5.7%). www.nature.com/scientificreports/ Table 4 ).

Self-confidence about the ability to protect themselves from SARS-CoV-2 infection, which was explored in Model 2, showed to be significantly higher in those who were involved in working activities in the institution (OR = 2.31; 95% CI 1.51-3.54), who did not report at least one common symptom compatible with COVID-19 in the previous 3 months (OR = 0.45; 95% CI 0.3-0.69), who did not show generalized anxiety symptoms (OR = 0.61; 95% CI 0.4-0.92), and did not express need of additional information about COVID-19 (OR = 0.46; 95% CI 0.3-0.71); moreover significant differences in self-confidence were revealed in the different investigated prisons (Model 2 in Table 4 ). www.nature.com/scientificreports/ Finally, older subjects (OR = 1.04; 95% CI 1.02-1.06), who knew that a COVID-19 vaccination is available (OR = 2.61; 95% CI 1.67-4.1), believed that COVID-19 is more serious than influenza (OR = 2.21; 95% CI 1.05-4.66), and were self-confident about their ability to protect themselves from SARS-CoV-2 infection (OR = 1.65; 95% CI 1.03-2.64), were significantly more willing to undergo COVID-19 vaccination, and significant differences in this willingness were also detected in the different institutions (Model 3 in Table 4 ).

The most frequently mentioned sources to acquire information about COVID-19 were media and newspapers (94.5%), followed by family and friends (35%), whereas only 16.9% reported physicians. Moreover, only 5.2% of participants had been involved in a prison education program and 75.6% wished to receive additional information about COVID-19 (Table 3 ).

As far as we know, this study is one of the few investigations that have explored in detail, in the context of the COVID-19 pandemic, the perspective of incarcerated people as regards to awareness and prevention of SARS-CoV-2 infection. The results have added knowledge on an understudied population providing useful insights to policymakers for the development of effective interventions aimed at contrasting the circulation of SARS-CoV-2 in prisons.

There are several relevant findings that warrant to be highlighted in respect to prevention of SARS-CoV-2 infection in people in prison.

First of all, after more than one year from the onset of the first cases of COVID-19 in Italy, the results of this study clearly show that knowledge about the main modes of transmission, such as the role of respiratory droplets as well as indirect transmission through contaminated hands, on severe consequences of COVID-19 for patients with underlying medical conditions, and on preventive measures, including vaccination, are widely spread in this population. These reassuring findings demonstrate that information on COVID-19 pandemic has reached also incarcerated subjects, and, although awareness of risks and of preventive measures does not directly imply the decision, ability or opportunity to implement protective behaviors, it may, however, provide the motivation and promote positive attitudes towards the adoption of preventive measures.

Moreover, the interpretation of results on attitudes has provided enlightening insights, since people in prison, expressing their concern about the possible consequences of COVID-19 for the potential for a huge spread in their institutions, as well as their specific risk of severe manifestations of COVID-19, have demonstrated a clear understanding of the seriousness of the pandemic for the threats to the safety of their institutional settings and, at the same time, for the implications related to the higher prevalence of medical conditions experienced by incarcerated people which are clearly perceived as a risk factor for severe complications of COVID-19. It is worth underlining, however, that this awareness is not coupled to self-confidence, since only one fifth declared to be confident in the ability to protect oneself from the SARS-CoV-2 infection. Therefore, since knowledge is satisfactory and attitudes show a conscious approach to the potential threats related to COVID-19, the lack of self-confidence appears to be related to perceived difficulties to protect themselves in that specific setting. The study did not directly investigate reasons of this lack of confidence, but it may be argued that it may be associated to the perception of overcrowding, since cells are shared by more than 90% of the participants, or, particularly in the first wave of the pandemic, by the lack or low availability of protective devices, such as face masks, hand disinfectants, etc.

These findings are coupled with a high level of anxiety and depression which were revealed to involve a consistent proportion of the studied population. Feelings of anxiety and depression have been frequently reported as a consequence of COVID-19 pandemic, even in subjects who did not directly experience the disease 22, 23 , and this psychological distress may have been exacerbated by the condition of isolation related to incarceration. This is confirmed by the results of the model constructed to investigate determinants of self-confidence in the ability of incarcerated people to protect themselves from the SARS-CoV-2 infection, that showed that generalized feelings of anxiety were negatively associated to self-confidence, whereas a working activity, that may be considered a proxy of a more satisfactory psychological condition, was a predictor of self-confidence. Indeed, according to the Italian legislation, work in prison is one of the elements of the social rehabilitation during the detention period and, according to several requirements (condition of detention, unemployment gained during the detention, number of years spent in prison, etc.) incarcerated people are given the opportunity to carry out working activities, which include salary and social security guarantees.

Intention to undergo COVID-19 vaccination was expressed by 64% of the surveyed subjects. This finding is higher than that reported in the only study exploring willingness in people in prison in the US (45%) 24 , but lower than that expressed in the general population (84.1%), and in HCWs (80.7%) in the same area 25, 26 , and in the general population in other areas such as in China, as reported by Wang et al. (82.6%) 11 and by Chen et al. (83.3%) 12 , US (75%) 27 , and Canada (82.8%) 28 . This is expected since even in the general population lower willingness has been reported by disadvantaged groups and has been associated to less trust toward policies promoted by health institutions or the government 27, 29 . It should be acknowledged, however, that the longer the time since the beginning of the pandemic, the higher the opportunity to increase one's knowledge and awareness about the preventive measures, including vaccination. Therefore, comparing results from studies performed at different times, involving different populations, and using different methodologies should be done with caution.

It is also of note that, as recently reported by a comprehensive systematic review, data on coverage for all vaccinations in people in prison are scarce and heterogeneous, and do not include all relevant vaccines for this group; moreover, published literature indicate that incarcerated people are under-immunized, particularly against HBV, influenza, MMR, and pneumococci 30 . Reported reasons include specific characteristics of the people in prison and their fast turnover, and poor attention to prevention interventions in this disadvantaged group 30 www.nature.com/scientificreports/ This is concerning, since COVID-19 has had a tremendous toll on both incarcerated people and personnel working in prisons, calling for actions aimed at urgent prioritization of COVID-19 vaccination in these settings. Reasons for considering COVID-19 vaccination a priority in prisons is also related to the high frequency of underlying chronic medical conditions revealed in people in prison, that are associated to COVID-19 more severe complications. In this context, the analysis of determinants of willingness to undergo vaccination provides useful advice for promoting COVID-19 vaccination campaigns among people in prison, since it showed that younger incarcerated people, those who do not perceive the severity of the disease, and are not aware of the availability of the vaccine and feel uncomfortable with the preventive measures against COVID-19 should be the target of messages focused on the promotion of the adherence to COVID-19 vaccination as a crucial tool in the struggle against COVID-19 spread both in prisons and in the community.

Adherence to the main COVID-19 preventive measures was declared by the great majority of respondents, but there is still a proportion of more than 10% who reported not wearing face masks and not washing/disinfecting hands in various circumstances. This is alarming, since in the absence of vaccination, these measures, coupled with physical distancing, have proven to be fundamental for contrasting SARS-CoV-2 transmission. Regarding these results, it should be acknowledged that only 16.9% reported to have been informed on COVID-19 by a physician. Since in Italy healthcare provided to incarcerated people is managed by the National Health System, and it is well-known that HCWs are a very trusted source for health-related prevention behaviors, including vaccinations 31-34 , a more incisive role of HCW involved in healthcare of incarcerated people in the education and counselling about prevention of COVID-19 should be suggested. Indeed, among the reasons reported for willing to undergo COVID-19 vaccination, only 19.2% reported the recommendation by a physician, whereas 22.4% of those who would refuse vaccination declared they had been discouraged by a physician. This is unacceptable and demands a more thorough investigation involving directly HCW working in correctional facilities.

There are some potential limitations in the study that are worthy of emphasis and should be considered when interpreting the results. First, since this was a cross-sectional study, it can only provide associations and it does not enable establishing a causal and temporal relationship between the potential determinants and the different outcomes of interest. Moreover, incarcerated people were asked to respond to a hypothetical situation. Their indication that they will accept a COVID-19 vaccine may not correspond to true uptake rates; these will only be measurable when they will be actually offered a vaccine. Moreover, attitudes and perceptions might change quickly, and these results might not be reflective of current reasons for not intending to receive a COVID-19 vaccine. Third, incarcerated people were enrolled from three prisons of Southern Italy, hosting only male subjects and therefore the study examines a sub-set of the entire incarcerated population, potentially limiting the generalizability of the results to the wider population of incarcerated males and females in Italy. Surveys including women should be performed. It should also be acknowledged that the response rate was higher than the 64.2% and 68% reported in recent previous surveys conducted in prison 24, 35 , therefore since the large majority of selected voluntarily participated, it is plausible to argue that the results of the survey would have not been substantially changed by the inclusion of those who were not recruited.

The study has demonstrated that the incarcerated people, a population with a high risk to acquire COVID-19, have acquainted an adequate knowledge about the main modes of transmission and the effective preventive measures, including vaccination. Moreover, they have shown a conscious approach to the potential threats related to COVID-19, whereas the lack of self-confidence in their ability to protect themselves from COVID-19 appears to be related to perceived difficulties associated to the specific setting. Finally, intention to undergo COVID-19 vaccine was not completely satisfactory. Therefore, public health response to COVID-19 in prisons should address vaccine hesitancy to increase vaccine confidence among people in prison given that early wholeinstitution vaccination can prevent outbreaks, ensure the basic rights of people in prisons, and protect staff and the wider community. Vaccine hesitancy is a very complex phenomenon and there is no definitive evidence available regarding specific effective interventions to address it, even if all the studies highlight the importance of understanding the specific concerns of various groups of hesitant individuals 36, 37 . However, in the literature the impact of physicians' recommendation on vaccination uptake among different at-risk groups has been well documented [38] [39] [40] [41] . Therefore, prison HCWs should be more extensively involved in providing information and vaccine recommendation in order to increase the awareness of people in prison on the benefits of vaccination and to address their concerns.

Study design and setting. This cross-sectional investigation was conducted from March 9 to April 28, 2021, and it was part of a larger project developed by the University of Campania "Luigi Vanvitelli" and the Joint Operational Unit for "Health Protection at Prison Institutions", to investigate several health-related issues in the incarcerated population. Three prisons in the geographic area of Campania region, in the South of Italy, hosting an average population of approximately 2125, 1164, and 954 adult incarcerated males, were included in the study. Each selected prison housed people awaiting trial and those who were definitively convicted, serving short or long sentences and consisted of sections that housed different groups according to low, medium or high security regimes.

A stratified sampling method was used to randomly select the study population. In particular, incarcerated people were stratified by their detention status. The strata were formed based on low, medium, or high security regime of incarcerated people and a proportional number of subjects were randomly selected from each group and invited to fill a self-administered questionnaire. Incarcerated women were excluded from sampling since a very small number of women are housed in women's enclosures of general prisons. www.nature.com/scientificreports/ Data collection. All directors of prisons were contacted through an invitation letter to present the study protocol and to obtain their approval to conduct the survey. Then, the selected subjects received an information sheet that explained the survey aims and procedures, that the participation was completely voluntary and anonymous, that privacy and confidentiality would be strictly protected, as no personal identifiers were included in the questionnaire. Moreover, a physician not involved in the care of incarcerated people, explained to them the purposes of the study, and a written informed consent was obtained before conducting the survey. The people in prison completed a self-administered questionnaire delivered in their prison cell. Those who were in special housing units or were unable to give informed consent for substantial cognitive impairment or were not able to read and comprehend Italian language were excluded.

Survey questionnaire. The questionnaire was used to explore several topics, including: (1) characteristics of incarcerated people, and information on their current detention, such as age, marital status, number of sons/ daughters, education level, employment status before and during detention, single or multiple episodes of incarceration, and living in individual or shared cells; (2) anamnestic characteristics, such as presence and type of underlying clinical conditions, having experienced the most common symptoms compatible with COVID-19 in the previous three months, and having undergone a screening test with RT-PCR for SARS-CoV-2 detection in the previous three months; (3) knowledge about COVID-19 (modes of transmission and preventive measures); (4) perceived severity and risk of developing the COVID-19, perceived ability to protect themselves from coronavirus, willingness or unwillingness to receive COVID-19 vaccine and related reasons, and level of anxiety and depression experienced during the pandemic period; (5) behavior regarding use of preventive measures, such as circumstances when masks were used and hands were washed/disinfected, eventual changes in their habits, in the three months preceding the survey, as a consequence of fear of contracting COVID-19, and related reason(s). Finally, (6) sources of and needs of information regarding COVID-19 were also explored. The response choices for all knowledge questions were on a three-point Likert-type scale using "true", "false", "do not know" options. For the statements on perception of severity, risk of developing COVID-19, and for all attitudes, response options were also on a three-point Likert-type scale (1 = agree, 2 = uncertain, 3 = disagree). Depression was evaluated by using the "Patient Health Questionnaire 2" (PHQ-2) that has been shown to be effective in screening for depression and it comprised the first 2 questions of the "Patient Health Questionnaire 9" (PHQ-9), whereas anxiety was evaluated with the Generalized Anxiety Disorder 2-item (GAD-2), a validated test to perform screening for anxiety disorder 42, 43 . Questions pertaining to willingness to receive the COVID-19 vaccine and those on behaviors were close ended with "yes" or "no" or multiple choices response format. A copy of the questionnaire is provided as additional file (Supplementary File S1).

Prior to the beginning of the survey, the questionnaire was pilot tested on 50 subjects to ensure correct interpretation, reliability and feasibility of the questions. The survey instrument was developed by research team based on items of questionnaires validated in previous investigations conducted by some of us regarding the knowledge, attitudes, and behavior about COVID-19 and other vaccinations in several at-risk groups 25, 26, [31] [32] [33] .

The study was approved by the Ethics Committees "Campania Centro" of the Local Health Unit Napoli 1 (protocol code: 297) and "Campania Nord" of the Local Health Unit Caserta (protocol code: 400). The research was conducted in accordance with relevant guidelines and regulations. Statistical analysis. The statistical Stata software (Version 15) was used to perform the analysis 44 . Descriptive analysis was used to explore the characteristics of the study population. Then, appropriate statistic tests (chisquare, Fisher's exact and Student's t-test) were conducted in bivariate analysis. Following, multivariate stepwise logistic regression analysis was performed to investigate predictors of perceived risk of developing COVID-19 (no = 0; yes = 1) (Model 1), of self-confidence in the ability to protect oneself from COVID-19 (no = 0; yes = 1) (Model 2), and of willingness to receive COVID-19 vaccination (no = 0; yes = 1) (Model 3). The independent variables that showed to be associated at the univariate analysis and were judged to potentially have influence to the investigated outcomes were included in the appropriate model. A detailed description of the independent variables included in each model and the related categories is reported in an additional file (Supplementary File S2). www.nature.com/scientificreports/

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The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

The authors wish to express their gratitude to those who participated in this study and were willing to share their information. Members of the Collaborative Working Group are: Giuseppe Nese (Prison "Francesco Uccella", Santa Maria Capua Vetere, Italy), Nicola Palmiero (Prison "Francesco Uccella", Santa Maria Capua Vetere, Italy), Vincenzo Maria Irollo (Prison "Giuseppe Salvia", Naples, Italy), Maria Rosaria Gemei (Prison "Pasquale Mandato", Naples, Italy), Elpidio Cicatiello (Prison "Pasquale Mandato", Naples, Italy).

Conceptualization, G.D.G., M.P.; methodology, G.D.G., M.P.; data acquisition: R.L.; formal analysis, G.D.G., C.P.P., R.L., F.N. and M.P.; data curation, G.D.G., R.L., F.N., C.P.P.; writing-original draft preparation, G.D.G., C.P.P., M.P.; writing-review and editing, G.D.G., C.P.P., F.N., M.P.; supervision, M.P. All authors have read and agreed to the published version of the manuscript.

The authors declare no competing interests.

Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1038/ s41598-022-04919-3.Correspondence and requests for materials should be addressed to M.P.Reprints and permissions information is available at www.nature.com/reprints.Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.