key: cord-0841076-5pbpu0bg
authors: Teluguakula, Narasaraju
title: Neutrophils set extracellular traps to injure lungs in COVID-19
date: 2021-01-28
journal: J Infect Dis
DOI: 10.1093/infdis/jiab050
sha: 40c2943a59ea497925ff1c8245fff390ee97c43e
doc_id: 841076
cord_uid: 5pbpu0bg

nan

A c c e p t e d M a n u s c r i p t Early clinical data on COVID-19 patients from Wuhan, China, published in March 2020, raised a red flag, as the investigators observed a progressive rise in neutrophilia in all non-survivors compared to survivors with mild to moderate disease. 4 Subsequently, numerous clinical reports confirmed neutrophilia in severely ill COVID-19 patients, in parallel with increased plasma levels of neutrophil-specific chemokines, NETs and neutrophil-to-lymphocyte ratios (NLR) 5 . These initial studies predicted neutrophilia and elevated NLR levels as early indicators of risk factors for severe COVID-19 illness. 6 However, it was unclear whether neutrophilia and/or plasma NETs reflect their elevated The Ouwendijk et al. study highlights active NETosis that occurs during clinical progression in patients with COVID-19, thus supporting the significant contribution of NETs to ARDS pathophysiology. The current prospective cohort study will also aid in identifying novel biomarkers of disease severity, as well as in designing therapeutic interventions to prevent NETs formation and to inhibit toxic constituents of NETs that exacerbate acute lung injury and ARDS in COVID-19.

The author has no conflicts of interest/funding to disclose.

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