key: cord-0840976-8nj9pfr3
authors: Middleton, Rachel J.; Gorton, Julie; O'Riordan, Edmond; Knight, Sean; Kalra, Philip A.; Poulikakos, Dimitrios
title: Impact of Shielding and First Dose of COVID-19 Vaccination in Kidney Transplant Recipients
date: 2021-09-02
journal: Nephron Clin Pract
DOI: 10.1159/000518631
sha: 6ab8e4dd328dfd4fb34c3e221a61313130b508ba
doc_id: 840976
cord_uid: 8nj9pfr3

nan

Dear Editor, We read with interest Riella et al.'s [1] article highlighting the importance of focused studies to optimise the protection of kidney transplant recipients (KTR) during the COVID-19 pandemic. We present data from our kidney transplant service regarding the effect of shielding upon COVID-19 incidence and the antibody response following the first dose of COVID-19 vaccination in our KTR.

In our population of 698 KTR in the north west of England, we have had 76 (10.9% of all KTR) symptomatic cases of COVID-19 diagnosed with nasopharyngeal RT-PCR over a period of 13 months from March 2020, with a COVID-19-related mortality rate of 22%. During the 3 months when shielding advice was paused (August to October 2020), 28 (36.8%) patients had COVID-19 infection, with 22 (78.5%) of these diagnosed in October 2020 ( Fig. 1 ) when the regional community incidence of CO-VID-19 was 529.5 cases/10,0000.

We performed COVID-19 antibody testing in 298 KTR during routine phlebotomy appointments prior to vaccination between December 2020 and February 2021. COVID-19 antibody testing was undertaken using the Public Health England-approved Siemens immunoassay, detecting antibodies targeting the spike protein S1 RBD [2] .

There were 55 out of 298 (18.4%) KTR with detectable COVID-19 antibodies prior to vaccination and 35 (63%) had previous asymptomatic disease. Of the 243 KTR with no detectable antibodies prior to vaccination, 70 KTR have also had antibody testing >12 days after their first COVID-19 vaccination (mean 40 days post-vaccination, range 12-79 days). Of these, only 16 (22.9%) developed detectable COVID-19 antibodies following the first dose vaccination (mean 38 days post-vaccination, range 14-64 days). Fifty-seven patients received mRNA vaccine (Pfizer BioNTech) and 11 received the adenovirus platform (Astra Zeneca Oxford) vaccine, and the vaccine platform was unknown in a further 2 patients. Eight KTR were diagnosed with COVID-19 infection more than 7 days following their first vaccine.

Our data confirm the high mortality associated with COVID-19 in KTR and highlights the need to shield when the prevalence of COVID-19 in the community is high. The low antibody response is concerning and consistent with data from Boyarsky et al. [3] in which only 17% of KTR reported detectable antibody response after a single COVID-19 vaccination dose. Our population similarly were predominantly taking tacrolimus and mycophenolate immunosuppression. Despite the promising vaccine effectiveness in the general population, KTR receiving immunosuppression are less likely to achieve an antibody response to COVID-19 vaccination following the first dose. Although these are only preliminary data, and we can expect further seroconversion following the second dose of vaccine assuming our 12 week vaccination schedule is consistent with Boyarsky et al.'s [4] updated results, further research is required to explore effective strategies to decrease the risk of infection from CO-VID-19 in this vulnerable population and to ascertain the best vaccine dosing schedule to maximise antibody protection in immunosuppressed KTR.

This study is exempt from ethical committee approval as the authors presented a retrospective study of the transplant population with all samples collected as part of routine care.

Professor Kalra has honoraria and consultation fees from Vifor, Astra Zeneca, Napp, Pharmacosmos, Bayer, and UCB, and research grants from Vifor, Astellas, BergenBio, and Evotec.

This was an evaluation of patients as part of their routine clinical care and no additional costs were incurred.

Rachel Middleton has participated in study design, data collection, analysis, and writing of the paper. Julie Gorton has participated in data collection. Dimitrios Poulikakos has contributed to the study design and writing of the paper. Sean Knight, Edmond O'Riordan, and Philip Kalra participated in writing of the paper.

Data from this paper are not available for public use. 

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