key: cord-0838002-yu87ygod authors: Rout, Amit; Chan, Abigail title: A Case of COVID-19 Complicated by Venous Thromboembolism Despite Being on Prophylactic Anticoagulation date: 2020-06-18 journal: J Med Cases DOI: 10.14740/jmc3500 sha: aaf52a590524ca3acb907269c4539959a14edfcc doc_id: 838002 cord_uid: yu87ygod The coronavirus disease 2019 (COVID-19) presents with variable clinical syndromes, from asymptomatic disease to acute respiratory failure. Complications such as acute respiratory distress syndrome (ARDS), secondary infection, acute cardiac injury, liver failure, renal failure, coagulable disorders and in many cases, death have been recognized. Venous thromboembolism (VTE) was found to be present in up to one-third of critically ill COVID-19 patients. Our case demonstrated a patient with COVID-19 who developed a massive pulmonary embolism leading to cardiac arrest, despite having an initial normal D-dimer level, normal chest imaging, and while maintained on appropriate VTE prophylaxis during hospitalization. The world is currently going through one of the biggest medical challenges of the 21st century, the coronavirus disease 2019 . With the advent of COVID-19, variable clinical presentations from asymptomatic to severe respiratory symptoms requiring intensive care unit (ICU) admissions have been seen. Complications such as acute respiratory distress syndrome (ARDS), secondary infection, acute cardiac injury, liver failure, renal failure, coagulable disorders and in many cases, death have been recognized [1] . Venous thromboembolism (VTE) has been reported in 25-31% of critically ill patients [2, 3] . We present a case of 62-year-old man diagnosed with COVID-19 pneumonia and respiratory failure whose course was complicated by cardiac arrest secondary to VTE. A 62-year-old man with underlying obstructive sleep apnea, hyperlipidemia, and depression, presented to the emergency department with shortness of breath, cough, and fever for the last 3 days. His wife was admitted at another institution with COVID-19 pneumonia. On arrival, he was afebrile, normal heart rate and blood pressure, slightly tachypneic, with oxygen saturation of 88% on room air. He was awake and conversant. Physical examination revealed mild respiratory distress, diffusely coarse breath sounds, no jugular vein distention, distinct heart sounds, and no peripheral edema. Pertinent laboratory findings were elevated: lactate dehydrogenase (LDH) of 422 U/L (normal value 84 -246 U/L), ferritin of 449 ng/mL (normal values 28 -365 ng/mL), C-reactive protein of 106 mg/L (normal values ≤ 9.9 mg/L), procalcitonin 0.14 ng/ mL (normal values ≤ 0.08 ng/mL). His troponin, complete blood count (CBC), creatinine, and liver function tests were normal. His prothrombin time (PT) and international normalized ratio (INR) were normal. His activated partial thromboplastin time (aPTT) was mildly prolonged 35.3 s (normal values 23 -26.1 s). D-dimer was 0.48 mg/dL (normal values ≤ 0.5 mg/dL). His COVID-19 polymerase chain reaction (PCR) testing was positive. Chest Xray showed multifocal interstitial and airspace opacities bilaterally without any pleural effusion which was confirmed with computed tomography (CT) angiogram of the thorax (Fig. 1 ). There was no evidence of pulmonary embolism. Electrocardiogram (ECG) on admission was normal sinus rhythm with T wave inversion in leads V1, V2 and V3, which was similar to a previous ECG. Initially, he was placed on nasal cannula at 6 L/min which was quickly advanced to mechanical ventilation given worsening hypoxemia. He was treated with empiric antibiotics and hydroxychloroquine. VTE prophylaxis was initiated using subcutaneous heparin and mechanical compression devices. During his hospital stay he was managed with mechanical proning and paralytics as per institutional COVID-19 ARDS protocol. He was slowly showing improvement while remaining on mechanical ventilator support by the day 10 of hospitalization. On the 11th hospital day, he became tachycardic, with heart rate up to the 130's. ECG showed a new right bundle branch block with S1Q3T3 pattern (Fig. 2) and elevated troponin. Prior to undergoing planned CT angiogram of thorax and Doppler ultrasonography to rule out VTE, he went into cardiac arrest. Advanced cardiac life support was started. The point-of-care ultrasonography (Fig. 3) . Intravenous heparin infusion was started. Despite maximum support, patient expired. This case demonstrates patients with COVID-19 are prone to develop large VTE which can lead to cardiac arrest, which is despite having an initial normal D-dimer level, imaging and while being on appropriate VTE prophylaxis during hospitalization. Approximately one-third of COVID-19 patients are being diagnosed with VTE. Autopsy findings of some COVID-19 patients revealed both micro-and macro-thrombi formation [4] . Pharmacologic VTE prophylaxis is recommended unless with high bleeding risks [2] [3] [4] [5] [6] . Patients with high risk for VTE are those who are critically ill, undergoing cytokine storm syndrome, having high levels of D-dimer, abnormal coagulation markers, and experiencing multi-organ failure. The use of empiric therapeutic doses of anticoagulation, higher doses of pharmacologic VTE prophylaxis, and post-discharge thromboprophylaxis in high-risk patients are still being investigated [4, 7] . Currently, a high level of D-dimer on admission is being used to determine patients with an increased risk for VTE. A study by Cui et al proposed a D-dimer threshold of > 1.5 mg/dL to determine VTE risk, with sensitivity and specificity rates of 85% and 89%, respectively. They found that patients who present with VTE tend to be older, have prolonged aPTT, lymphopenia, and higher Ddimer levels (5.2 vs. 1.2 mg/mL, P < 0.001) when compared to patients without VTE [2] . Serial laboratory markers especially D-dimer and imaging for VTE should be considered in patients with severe COVID-19 disease. Use of prophylactic anticoagulation versus therapeutic anticoagulation in these patients with negative imaging for VTE remains controversial. Full dose anticoagulation is associated with increased risk of bleeding, thus before recommending empiric use further studies are needed to establish mortality benefits. Patients with COVID-19 who are on the severe side of the disease spectrum have increased risk of VTE despite being on prophylactic dose of anticoagulation. A high index of suspicion for VTE should be maintained all the time. Further studies evaluating empiric initiation of therapeutic anticoagulation is needed. Clinical and immunological features of severe and moderate coronavirus disease 2019 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Abnormal Hemostatic Parameters and Risk of Thromboembolism Among Patients With COVID-19 Infection ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia COVID-19 and VTE/Anticoagulation: frequently asked questions Doppler ultrasonography of lower extremity. Non-compressible and diminished Doppler signal of right peroneal (a), right posterior tibial veins (b), left peroneal (c), and left posterior tibial veins (d) indicating thrombi None to declare. None to declare. None to declare. Not applicable. AR and AC contributed equally in conceptualizing, data reviewing and writing of this manuscript. The authors declare that data supporting the findings of this study are available within the article.