key: cord-0836904-lgwicx2s
authors: Sharun, Khan; Singh, Rajendra; Dhama, Kuldeep
title: Oxford-AstraZeneca COVID-19 vaccine (AZD1222) is ideal for resource-constrained low- and middle-income countries
date: 2021-03-31
journal: Ann Med Surg (Lond)
DOI: 10.1016/j.amsu.2021.102264
sha: ed71d6716acd9ddacea0e352b8245dd913baac16
doc_id: 836904
cord_uid: lgwicx2s

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T he A straZ eneca/O x ford C O V ID -19 vaccine was found to possess similar immunogenicity 32 across all age groups following a booster dose [2] . S imilarly, the randomized controlled trial 33 conducted to evaluate the efficacy of Pfizer/B ioN T ech v accine (B N T 162b2) enrolled 43,548 34 participants having 16 years of age or more [6] . T he studies conducted among the younger 35 and older adults hav e already established the immunogenicity and safety profile of the 36 Pfizer/B ioN T ech vaccine [11, 12] . T he randomized controlled trial that confirmed the efficacy 37 of M oderna v accine (mR N A -1273) enrolled 30,420 participants aged 18 years and older [10] . 38 F urthermore, the phase 2 trial that evaluated the safety and immunogenicity confirmed robust 39 immune responses without any adverse effects in healthy adults vaccinated with the mR N A -40 1273 vaccine. T he vaccine also ex hibited similar immunogenicity in younger (18- vaccinations#what-share-of-the-population-has-received-at-least-one-dose-of-the-covid- 

Vaccine 206 strategies: Optimising outcomes. Vaccine

F igur e 2: T otal number of C O V ID -19 vaccine dose administered as on M arch 18, 2021. R eproduced from O ur W orld in D ata

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