key: cord-0836758-dklr0yui
authors: Zeduri, Margherita; Vigezzi, Giacomo Pietro; Carioli, Greta; Lugo, Alessandra; Stival, Chiara; Amerio, Andrea; Gorini, Giuseppe; Pacifici, Roberta; Politi, Pierluigi; Gallus, Silvano; Odone, Anna
title: COVID-19 lockdown impact on familial relationships and mental health in a large representative sample of Italian adults
date: 2022-03-28
journal: Soc Psychiatry Psychiatr Epidemiol
DOI: 10.1007/s00127-022-02273-3
sha: 411e2e2337f266105de56273455955fb43c826b8
doc_id: 836758
cord_uid: dklr0yui

PURPOSE: Benefits of national-level stay-at-home order imposed in Italy to prevent SARS-CoV-2 transmission need to be carefully weighed against its impact on citizens’ health. In a country with a strong familial culture and where welfare relies on households, confinement drastically decreased support provided by elder relatives, which may have resulted in mental health worsening. METHODS: A web-based cross-sectional study (LOST in Italy) was conducted on a representative sample of Italian adults during lockdown (27th of April–3rd of May 2020). We asked 3156 subjects to report on reduced help in housework and childcare from retired parents to assess the impact of confinement on mental health, through validated scales before and during lockdown. RESULTS: Overall, 1484 (47.0%) subjects reported reduced housework help from parents, and 769 (64.0%, of the 1202 subjects with children) diminished babysitting support. Subjects reporting reduced housework help had worsened sleep quality (multivariate odds ratio, OR = 1.74, 95% confidence interval, CI 1.49–2.03) and quantity (OR = 1.50, 95% CI 1.28–1.76), depressive (OR = 1.32, 95% CI 1.14–1.53) and anxiety symptoms (OR = 1.53, 95% CI 1.32–1.78), compared to those reporting unreduced help. Worsening in sleep quality (OR = 2.32, 95% CI 1.76–3.05), and quantity (OR = 1.80, 95% CI 1.36–2.37), depressive (OR = 1.79, 95% CI 1.39–2.31) and anxiety symptoms (OR = 1.90, 95% CI 1.48–2.46) was also associated with reduced babysitting help. Mental health outcomes were worse in subjects with poorer housing and teleworking during lockdown. CONCLUSION: Confinement came along with reduced familial support from parents, negatively impacting household members’ mental health. Our findings might inform evidence-based family and welfare policies to promote population health within and beyond pandemic times.

Coronavirus disease 2019 (COVID-19) outbreak impacted communities worldwide and, two years after the first cases, it is globally responsible for more than 373.2 million cases and more than 5.7 million deaths [1] . Italy became the first COVID-19 epicentre in Europe and, on the 9th of March 2020, it was also the first country to impose a nationwide stay-at-home order as an attempt to reduce the exponential virus spread and alleviate acute pressure on the healthcare system [2, 3] . The Italian-wide confinement order (i.e., national lockdown) lasted for 2 months until the 3rd of May and confined over 60 million people inside their homes. Italians were forced to remain at their residence home unless for basic necessities (e.g., food, shopping) or health issues. Public services (schools, shops, gyms, bars and restaurants) were closed; gatherings were forbidden either in public or private places, and a series of infection protection and control measures were recommended (mask-wearing, hand washing or hand rubbing, respiratory etiquette, physical distancing). These non-pharmacological measures are considered among the most radical ones implemented so far [4] and among the most exceptional public health measures ever imposed [5] . In compliance with these restrictions, sudden and radical changes occurred in millions of Italians' daily life and behaviours [6] . Physical distancing and self-isolation strongly impacted social, working, and family habits, drastically reducing any form of socialisation [7] . This occurred in a country with a solid social and familial culture, where elder populations are actively involved in younger generations' family life [8] . Within Europe, Italy holds among the highest financial transfer and social support rates from older to younger generations, with subjects > 70 years still being net givers [9] . Italy, together with other southern European countries, has "familistic" societies [10] with weaker welfare policies and governmental family benefits, as compared to Western European standards [11] . As a consequence, Italian welfare is mainly based on family support, with grandparents acting as caregivers for grandchildren on a regular basis, helping with cooking and housework, and often providing emotional and informational support [12] . As a matter of fact, in Italy, older people constitute a fundamental and beneficial resource for the provision of informal family support [10] . During COVID-19 national lockdown, since in Italy, people aged 65 years or over live alone (29.7%) or with a partner (42.2%) [13] , Italian families limited their contacts with older relatives because of the stay-at-home order. Moreover, at the highest risk for COVID-19 death, older people also isolated themselves due to fear of infection [14] . Therefore, the availability of informal family care provided by elder relatives might have been substantially reduced, this adding to the burden on families already caused by schools and childcare facilities' closures. Italian households had to deal with new needs and faced daily routines without support from retired parents. Changes in social connections in a context of stress and uncertainty might have negatively impacted households' mental health. Without denying the benefits of national lockdown on COVID-19 control, investigating the impact of the pandemic on mental health from a multidisciplinary and familial perspective is a research priority [15, 16] , even more so in a country with a demographic and social structure like the one described for Italy.

Within the 'LOckdown and lifeSTyles in Italy' (LOST in Italy) study [17] , we explored the impact of national lockdown on selected mental health outcomes in a representative sample of Italian households, analysing the association with changes in housework and childcare help from retired parents.

This study is based on the LOST in Italy study, a web-based cross-sectional study conducted on a representative sample of 6003 Italian adults aged between 18 and 74 years [17] [18] [19] [20] . Lombardy region, the most affected by COVID-19 in Italy, has been oversampled. From the full sample, the current study selected subjects with at least a retired parent (n = 3156) and, within this sub-sample, those with at least one child aged 0-14 years (n = 1202).

Doxa, the Italian branch of the Worldwide Independent Network/Gallup International Association, conducted the survey in collaboration with the Italian National Institute of Health (Rome, Italy), Mario Negri Institute for Pharmacological Research (Milan, Italy), the University of Pavia and other institutions. Survey participants were selected among the Doxa online panel, which today includes about 40,000 active panellists (subjects who have participated in at least one research over the last 12 months, with an average refresh of 25%). Data were collected during the nationwide lockdown, from the 27th of April to the 3rd of May 2020. The study protocol obtained the ethics committee's approval (EC) of the coordinating group (i.e., EC of Besta Neurological Institute, Milan, Italy; file number 71-73, April 2020), and consent to participate was collected for all participants.

Recruited subjects were interviewed using an online selfadministered questionnaire about their lifestyle habits (e.g., sleep quality and quantity), mental distress (e.g., anxiety and depressive symptoms) and quality of life before and during the lockdown. The questionnaire included information on demographic and socioeconomic variables and anthropometric data. Subjects were asked how the help for housework (e.g., bills, cleaning, housekeeping) and babysitting from retired parents had changed during lockdown (unchanged, reduced, or increased, exposure of interest).

To quantify the impact of COVID-19 lockdown on participants' mental health, we focused on sleep quality and quantity, depressive and anxiety symptoms, quality of life, asking interviewees to answer questions with reference to both before and during the lockdown. These aspects were analysed using validated scales [20] .

Sleep quality and quantity were assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire [21] . Concerning the subjective evaluation of sleep quality, it was used PSQI item number 9. The participants were considered "poor sleepers" when they reported "quite bad" or "very bad" sleep quality. Survey participants were asked to answer also to PSQI item number 4, estimating how many hours of sleep they get at night, both during the 4 weeks before the lockdown and the last 4 weeks before the questionnaire administration. Sleep under 6 h per night was considered insufficient. We considered a worsening in sleep quality and quantity if participants reported decreased sleep quality scores and the number of hours slept at night, respectively.

The presence of depressive symptoms was established using the 2-item Patient Health Questionnaire (PHQ-2), based on the 9-item validated scale (PHQ-9) [22] . Survey participants were asked to estimate how much they were unable to feel pleasure, and they felt down in the dumps, depressed or hopeless 2 weeks before and during the lockdown. A score of PHQ-2 ≥ 3 indicated the presence of depressive symptoms.

Anxiety symptoms were assessed using the 2-item Generalised Anxiety Disorder (GAD-2), a short version of the 7-item scale (GAD-7) [23] . The GAD-2 asked participants to assess the frequency of feeling nervous, anxious or on edge 2 weeks before and during the lockdown. The second question investigated subjects' worrying self-control before and during the lockdown. A score of GAD-2 ≥ 3 indicated the presence of anxiety symptoms. Higher PHQ-2 and GAD-2 scores during the lockdown than before stated worsening depressive and anxiety symptoms, respectively.

Quality of life was measured using a Visual Analogue Scale (VAS) ranging between 1 (low quality of life) and 10 (high quality of life) [24] . A score of VAS < 6 indicated a low quality of life. Responders were asked to fill out the scale with reference to both before and during the lockdown. A VAS score during the lockdown lower than that reported before it defined a worsening in quality of life.

A statistical weight has been used to ensure the representativeness of the Italian sample. Such weight was computed as a combination of two distributions of the Italian population aged 18-74: (i) sex by age (18-24, 25-34, 35-44, 45-54, 55-64, 65-74 years) by geographic area (Northwest, Northeast, Centre, South of Italy, Islands); (ii) region (the largest official area into which Italy is divided) by municipality size (5 categories). Using multiple logistic regression models, we estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for participants who worsened their mental health outcomes differentiating between subjects reporting reduced compared to unchanged or increased help in housework and babysitting from retired parents. We included sex, age group (< 40, 40-49, ≥ 50 years), level of education (low, intermediate, high), geographic area of residence (North, Center, South and Islands) and marital status (married, divorced/separated, widowed, single) as covariates of our model. We conducted analyses stratified by: (i) working conditions (teleworking, employed at workplace, job loss during lockdown, unemployed); and (ii) living conditions (outdoor space availability and persons per room at home). All statistical analyses were performed using SAS 9.4 (SAS Institute, Inc., Cary, NC, USA). Table 1 reports the characteristics of the study population, including sociodemographic, exposures and outcomes distribution. Of 3156 subjects included in the analysis, 1202 (38.1%) had at least one child aged 0-14 years.

Forty-seven per cent of study subjects reported a reduction in help for housework from retired parents during national lockdown; for 47.5% of subjects, it did not change, while 5.5% reported an increase of help. With reference to help for babysitting, 64.0% of subjects reported a reduction; for 32.4% of subjects, it did not change, while 3.6% reported an increase.

Overall, 36.2% and 31.9% of subjects reported worsened sleep quality and quantity during lockdown, respectively. Depressive and anxiety symptoms increased in, respectively, 46.5% and 42.3%, while the quality of life was reported to have worsened during lockdown in 65.1% of the study population (Table 2 ). Table 2 also shows the prevalences and the adjusted ORs of worsening mental health outcomes (sleep quality and quantity, depressive and anxiety symptoms and quality of life), according to a reduced or unreduced help in housework and babysitting help from parents. Subjects reporting decreased help in housework were more likely to have worsened sleep quality and quantity (OR = 1.74, 95% CI 1.49-2.03 and OR = 1.50, 95% CI 1.28-1.76, respectively), depressive and anxiety symptoms (OR = 1.32, 95% CI 1.14-1.53 and OR = 1.53, 95% CI 1.32-1.78, respectively), and worsened quality of life (OR = 1.46, 95% CI 1.25-1.70), as compared to unreduced help. With reference to help in babysitting, decreased help was related to a worsening in sleep quality and quantity (OR = 2.32, 95% CI 1.76-3.05 and OR = 1.80, 95% CI 1.36-2.37, respectively), depressive and anxiety symptoms (OR = 1.79, 95% CI 1.39-2.31 and OR = 1.90, 95% CI 1.48-2.46, respectively), and worsened quality of life (OR = 1.50, 95% CI 1.16-1.93), as compared to unreduced help. As reported in Supplementary Table S1, excluding subjects who reported an increase in housework and babysitting help, estimates for those who experienced reduced help did not change substantially. Table 3 reports the prevalences, the adjusted ORs and the corresponding 95% CIs of individuals worsening mental health outcomes of interest according to unreduced and reduced housework and babysitting help from parents during lockdown, by working conditions. Within workers, a worsening in mental health in subjects reporting reduced housework help from parents might be more frequent in those employed at the workplace during lockdown, as compared to those teleworking (apart from quality of life worsening); the Table 3 Distribution of Italians with at least a retired parent having worsened their sleep quality, sleep quantity, depressive symptoms, anxiety symptoms and quality of life during the COVID-19 lockdown, according to the changes in housework and babysitting help from parents by working conditions during lockdown (reduced vs unreduced*). Corresponding odds ratios** (ORs) and 95% confidence intervals (CIs). Italy, 2020 *The subgroups of those reporting unchanged and increased help from parents were grouped because of the smallness of the "increased help" subsample (174 and 43 subjects increasing housework and babysitting help, respectively) **ORs and 95% CIs were estimated using unconditional multiple logistic regression models after adjustment for sex, age group Table 4 reports the prevalences, the adjusted ORs and the corresponding 95% CIs of individuals worsening mental health outcomes of interest according to unreduced and reduced housework and babysitting help from parents during lockdown, by housing conditions. Worsening mental health in subjects reporting reduced housework help from parents during lockdown might be more frequent in those living in houses with no outdoor space, as compared to those living in houses with garden or balcony (apart from depressive symptoms worsening); the difference was highest for worsened sleep quality, even if not significantly (no outdoor space: OR = 2.15, 95% CI 1.57-2.96 vs outdoor space: OR = 1.61, 95% CI 1.34-1.93). Similar patterns emerged in subjects reporting reduced help from parents in babysitting, whose risk of worsened mental health outcomes during lockdown was higher if living in houses with no outdoor space (apart from anxiety symptoms worsening), with the largest risk difference reported for depressive symptoms (no outdoor space: OR = 2.18, 95% CI 1.20-3.98 vs outdoor space: OR = 1.78, 95% CI 1.33-2.37). About the number of persons per room, worsened mental health outcomes might be more reported in those who experienced reduced housework and babysitting help from parents during the lockdown and living with high house density (number of people per room > 1), as compared to the total sample (except the quality of life). The highest, not significant difference was assessed for sleep quantity in those reporting reduced housework help (N people per room > 1: OR = 1.97, 95% CI 1.35-2.88 vs total sample: OR = 1.50, 95% CI 1.28-1.76) and for sleep quality in those reporting reduced babysitting help (N people per room > 1: OR = 3.38, 95% CI 1.97-5.81 vs total sample: OR = 2.32, 95% CI 1.76-3.05).

Findings from our large representative sample of Italian adults indicate the reduction in housework and childcare help from retired parents during nationwide confinement to be associated with a greater probability of worsened mental health outcomes. A trend towards stronger associations was reported in subjects employed at their workplace (as opposed to teleworking from home) and in those with poorer housing conditions.

Stay-at-home orders have been proved to effectively contain the SARS-CoV-2 spread at the population level [25, 26] . However, as confirmed by studies conducted both in Italy [20, [27] [28] [29] [30] [31] [32] [33] and in other countries [34] [35] [36] [37] [38] [39] [40] , confined individuals are significantly more likely to report mental distress, anxiety and depressive symptoms, and sleep disturbances.

Within the LOST in Italy project, we have already reported [20] that during lockdown in Italy, the nationallevel prevalence of depressive and anxiety symptoms doubled, getting to affect more than one-third of the general adult population (respectively, 33% and 42%). Insufficient and unsatisfactory sleep and unsatisfactory quality of life registered analogous increases, reaching a mean 40% prevalence during lockdown and quite remarkable percentage changes compared to before the lockdown. We observed almost the same prevalence in our subsample, comprising adults with at least one retired parent. Overall, the available literature supports the pandemic's independent and unprecedented effect on general population mental health, but still, scant data are available on mediators of this association.

In particular, no data have been published so far about the potential role of familial relationships and support during COVID-19 national lockdown. Our analysis explored the possible consequences of lack of familial support on households' stability: worsened mental health in adults lacking older relatives' help during lockdown confirms that Italian welfare deeply relies on family support [8] and raises awareness of the vulnerability of Italian families because of their dependence on older relatives [41] . Indeed, social networks and family members' support represent crucial elements for individual wellbeing and strong predictors for mental health issues [42] [43] [44] [45] [46] .

We observed a not significant but consistent stronger association between reduced help in childcare and worsened mental health outcomes, as compared to reduced housework help. This difference might be explained by the large proportion of Italian grandparents (about 40% according to SHARE data) [47, 48] providing essential daily childcare to their families before the pandemic, with beneficial impacts for themselves and the whole household [49] . Conversely, housework help does not include the unique emotional support intrinsic to childcare supplied by grandparents.

Among the different mental health outcomes considered, larger effects were reported for anxiety symptoms and sleep disorders, especially among adults younger than 60 years [50] , as compared to depressive symptoms and worsened quality of life. Taking into consideration the survey's timing, we can assume that mental health was mainly affected by short/mid-term effects of confinement, emergency awareness, infection fear and uncertainty about the future. In fact, as emerges from available literature, anxiety and sleep ORs calculated on the subsample of those with at least a son aged between 0 and 14 years (n = 1202 subjects) disturbances are earlier signs and predictors of mental distress [51] [52] [53] . Compared to those who shifted to teleworking during the lockdown, subjects employed at the workplace might have experienced worse mental health status decline. People working at the workplace without grandparents' help at home might have suffered more both from heavy work shifts and exceptional workload to cope with the ongoing emergency (e.g., health workers or other essential jobs), as well as from drastically reduced available time for housework and childcare [54] . Furthermore, fear of infection at workplaces might have played a role, consistently with available evidence on the topic that associates working with emerging infectious diseases exposure risk to worse mental health outcomes [55, 56] .

Reduced help in both housework and childcare was associated with a trend towards a greater risk of worse mental health in subjects reporting poor housing than in those with better living spaces. If, on the one hand, poor housing can be considered a proxy of lower socioeconomic status and a well-known risk factor for mental health [57] [58] [59] [60] , on the other hand, our findings suggest that not having an outdoor space (i.e., garden or balcony) and living in smaller houses increased the negative effect of having to look after children without help from grandparents during lockdown. Several hypotheses could be proposed to untangle this association. In compliance with the stay-at-home order, living in a house without a garden or a balcony might have caused worries about the lack of a place where children could play. Moreover, subjects were unable to enjoy the sun and the open air, this differentially adding to the risk posed on mental health by reduced help. The reduction of personal space and a daily chaotic routine, especially with children, could further explain the unease experienced by those living in small liveable spaces. Our findings are consistent with previous evidence: outdoor spaces and green elements are associated with a wide range of health benefits for all age groups, reducing stress and mental fatigue and mitigating emotional states, such as stress, depressive and anxiety symptoms [61] [62] [63] . Moreover, crowded living spaces usually stand for large families, which represent a risk factor for COVID-19-related worries [64] .

Finally, as additional housework and childcare associated with COVID-19 fell mainly on women [65] and we demonstrated that grandparents' help reduction resulted in worsened mental health, our findings could help to understand the higher odds for worsened mental health outcomes observed in young women during national lockdown [20, 32, 33, 66] .

This study needs to be interpreted in light of several strengths and limitations.

To our knowledge, the LOST in Italy project is the first multidisciplinary study conducted on a large national representative sample exploring the effects of COVID-19 public health response in Italy on various behavioural risk factors, physical and mental health outcomes. The large and representative sample size distinguishes our work from other published surveys with less rigorous sampling methods and allows us to propose a fair generalisation to other settings with a similar family culture. In particular, ours is the first analysis exploring lockdown consequences on family support and mental health. The adopted study design acknowledged simulating a pre-post analysis in the context of a cross-sectional study, exploiting the first-wave nationwide lockdown as a quasi-natural experiment [67] . The use of validated evidence-based scales ensured a rigorous assessment of mental health symptoms.

Concerning limitations, the cross-sectional nature of our data does not allow us to infer causality between exposure and outcomes. Nevertheless, the direction of the nexuses is supported by social and biological plausibility. Longitudinal studies might therefore confirm results. Potential selection bias could be due to the online panel. However, a computerassisted personal interviewing (CAPI) questionnaire was not possible during the COVID-19 lockdown, while a computerassisted telephone interviewing (CATI) questionnaire presented limited coverage in such a relatively young population. Other limitations include potential information bias due to self-reported responses and a possible recall bias since participants were asked to report their habits and psychophysical indicators before the lockdown at the time of the interview. Furthermore, the PHQ-2 and GAD-2 scales used to assess depressive and anxiety symptoms only represent a first step screening. We also were not able to specifically take into account the representativeness of our subsamples for having at least one retired parent and children, adding this information to the statistical weight used. Yet, no major bias was derived since the whole sample was designed to be representative of the Italian population in terms of sex, age, geographic area, region and municipality size.

Our analysis informs about the importance of social networks and support within families provided by older relatives both as a resilience factor and a potential vulnerability that affects mental health outcomes [46] . This element should be considered in future public health responses, including those requiring large-scale lockdowns, quarantines or physical distancing.

First, epidemiological monitoring and screening campaigns should be timely promoted to identify people at risk of poor social and familial support and prevent further mental health problems. Secondly, informative interventions on how to deal with the mental health consequences of the pandemic and about where to get the support needed should be implemented. Finally, tailored, innovative psychosocial interventions are urged to support at-risk populations and potentially help to buffer other risk factors for mental health. Moreover, targeted community-level welfare initiatives and social policies, especially nursery schools, kindergartens, or family crèche, could limit young generations' household dependence on older relatives' support for childcare, with long-term beneficial consequences for all the family members. Employers could play a relevant role in financing these childcare benefits with positive consequences on workers' mental health, especially women.

These recommendations should become part of the public health and social security strategy in general and in times of emergencies, from which mental health and related inequalities could greatly benefit [68] . Health and social services response should be designed to address mental health needs and mitigate significant long-term health costs caused by the pandemic's unprecedented stressfulness and unknown duration [69] .

To the best of our knowledge, this is the first sizeable original study providing representative estimates of the impact of nationwide lockdown measures on reduced familial welfare and households' support from retired parents and, consequently, worsened mental health. We observed that national lockdown measures came along with reduced housework help supply for a large proportion of Italian adult parents who presented an increase in depressive and anxiety symptoms, sleep disorders with an unsatisfactory quality of life. Moreover, our study suggests how selected determinants and mediators, including working and housing conditions, might have worsened these changes in different behavioural, environmental and socioeconomic dimensions.

Familial support is a key determinant of mental health, the quality of which also depends on working status and conditions, house environment, and social connections. As confirmed by our results, a global, multi-level socioeconomic interdisciplinary approach involving public mental health, epidemiology, and social sciences [70] is needed to better investigate through longitudinal designs the effects of familial support changes on mental health outcomes (e.g., wellbeing, mental distress, depressive and anxiety symptoms) and to inform evidence-based family and welfare policies and prevention strategies centred on population wellbeing, within and beyond pandemic times.

Author contributions AO, together with SG and AL, conceptualised and designed the study. RP and AO obtained funding. MZ, together with CG and AO, contributed to the implementation of the research and the analysis of the results. MZ, GPV, together with AO, wrote the first draft of the manuscript. All authors provided important contributions for the interpretation of findings and contributed to the final version of the manuscript. All authors carefully revised the final version of the manuscript. All the authors read and approved the last version of the manuscript.

Funding The survey was co-funded by the Italian National Institute of Health (ISS) and Fondazione Cariplo. The work of SG, AL and CS is partially supported by a research grant of the DG-Welfare of Lombardy Region (Call: Progetti di ricerca in ambito sanitario connessi all'emergenza COVID-19; DGR n. XI/3017). The work by AA and GS is partially supported by a grant of the AXA (AXA Research Fund -Call for Proposals . The work of GG is partially supported by the Tuscany Region within the Lost in Toscana Project. This research was supported by Istituto Superiore di Sanità, Fondazione Cariplo (Grant 2018-0863), AXA Research Fund, Regione Lombardia, Regione Toscana.

The datasets supporting the conclusions of this study are available from the corresponding author upon request.

Conflict of interest Each author declares that he or she has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent/licensing arrangement) that might pose a conflict of interest in connection with the submitted article.

Ethics approval and consent to participate and for publication Ethics approval and consent to participate and publication for this noninterventional study derived from EC of Besta Neurological Institute, Milan, Italy; file number 71-73, April 2020. The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000.

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