key: cord-0836025-7tu0p7hx authors: Vianello, Andrea; Braccioni, Fausto title: Geographical overlap between alpha-1 antitrypsin deficiency and COVID-19 infection in Italy: casual or causal? date: 2020-05-31 journal: Arch Bronconeumol DOI: 10.1016/j.arbres.2020.05.015 sha: 3a614b4298226fa51dceba37111f7b334486fc6b doc_id: 836025 cord_uid: 7tu0p7hx nan J o u r n a l P r e -p r o o f This work was not funded by any organization. All the authors declare that they do not have any potential or actual conflicts of interest including financial or personal relationships with persons or organizations that could have inappropriately influenced (biased) the study. No study sponsor was involved in designing or conceptualizing the study, in collecting, analyzing/interpreting the data, in drafting the manuscript or in the decision to submit the manuscript for publication. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report -120 Italian Government -Civil Protection Department Genetic epidemiology of alpha-1 antitrypsin in southern Italian registry of patients with alpha-1 antitrypsin deficiency SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and Is blocked by a clinically proven protease Inhibitor