key: cord-0835002-780u7tzz
authors: Garnier, Matthieu; Curado, Adelya; Billoir, Paul; Barbay, Virginie; Demeyere, Matthieu; Dacher, Jean-Nicolas
title: Imaging of Oxford/AstraZeneca COVID-19 vaccine-induced immune thrombotic thrombocytopenia
date: 2021-04-28
journal: Diagn Interv Imaging
DOI: 10.1016/j.diii.2021.04.005
sha: ab26eee52c2e10bf926523762d76b137cd727c47
doc_id: 835002
cord_uid: 780u7tzz

nan

Matthieu Garnier a* , Adelya Curado a , Paul Billoir b , Virginie Barbay b , Matthieu Demeyere a , Jean-Nicolas Dacher a,c , MD Figure 1C ). In addition, mesenteric venous enlargement and intraluminal filling defects, bowel wall edema and decreased ileal wall enhancement suggested venous mesenteric ischemia ( Figure 1D ). The patient was given corticosteroids, plasmatic exchange and anticoagulants. Magnetic resonance imaging of the brain 14 days later showed minor sylvian and border zone infarcts, with mild hemorrhagic changes. At day 15, only gripping difficulties and minor phasic troubles were remaining.

As observed in COVID-19 [6] , Oxford/AstraZeneca vaccine may induce hypercoagulable state that could lead to concomitant venous and arterial thromboses. In our patient, immunoassay and confirmatory functional assay for PF4 antibodies were positive and consistent with vaccineinduced immune thrombotic thrombocytopenia, a disease that resembles heparin-induced thrombocytopenia. Post-vaccination thrombosis has been recently described, but imaging findings have rarely been reported. Although very rare, occurrence of multiple thrombosis in the days following Covid-19 vaccine should urge extensive evaluation in order to approach the diagnosis. Multimodality imaging has a pivotal role in the diagnosis and treatment of such condition.

The authors declare that the work described has been carried out in accordance with the Declaration of Helsinki of the World Medical Association revised in 2013 for experiments involving humans.

The authors declare that this report does not contain any personal information that could lead to the identification of the patients. The authors also confirm that the personal details of the patients have been removed.

The authors declare that they have no competing interest.

This work did not receive any grant from funding agencies in the public, commercial, or notfor-profit sectors.

All authors attest that they meet the current International Committee of Medical Journal Editors (ICMJE) criteria for Authorship. Decreased ileal wall enhancement (arrowhead) consistent with venous mesenteric ischemia is also present. '

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