key: cord-0834193-p0orkd1z authors: Meira e Cruz, Miguel; Sweetman, Alexander title: Insomnia, Sleep Apnea, and Circadian Misalignment as a “Three-arm” Contributor to Anxiety and Depression During Pregnancy date: 2021-08-16 journal: Sleep Vigil DOI: 10.1007/s41782-021-00163-3 sha: 3ca8ab30f7ab3913bc6b1d22d5b1be514d81f19c doc_id: 834193 cord_uid: p0orkd1z nan estimates reported by Li and colleagues [1, 2] . Different reasons could be implicated in these contrasting findings such as differences in the study population, assessment tools and criteria (e.g., a different threshold on the PHQ-9 depression measure), and the temporal impact of COVID-19 epidemic during data collection. Despite these contrasting prevalence estimates, individual characteristics both associated to sleep disturbance (i.e., insomnia) [3] and to circadian clock phenotypes likely play an important role in the link between disturbed sleep and psycho-emotional health during pregnancy [1, 4] . Difficulties initiating sleep (one of the three core nocturnal symptoms of insomnia disorder) were strongly associated with the presence of both anxiety and depression symptoms. Although this study did not assess for difficulties maintaining sleep or early morning awakenings (the other main nocturnal insomnia symptoms), or chronicity of insomnia symptoms, previous research has established insomnia as an important risk factor associated with the development of depression [5] and has reported a high prevalence of insomnia symptoms during pregnancy [6] . Anxiety and depression are also powerful psychological mechanisms that may impact sleep physiology. Indeed, relationships between circadian rhythmicity, sleep and mood have been established in gestational insomnia, that may lead to post-partum depression [7] . The most effective treatment for insomnia, Cognitive Behavioural Therapy for insomnia (CBTi), improves sleep and symptoms of depression, anxiety and stress [8] . A recent randomized controlled trial also recently reported that (digital) CBTi improves sleep during and following pregnancy, compared to sleep education control [9] . As highlighted by Lin and colleagues [1] , targeted interventions to improve sleep conditions among pregnant women may be important in improving associated mental health symptoms. Importantly, insomnia and OSA commonly co-occur [10] . OSA is characterized by frequent narrowing (hypopnea) and/or closure (apnea) of the upper airway during sleep, resulting in reduced oxygen saturation, cortical [11] . Like insomnia, OSA is also associated with symptoms of anxiety and depression [10, 11] . Co-morbid insomnia and sleep apnea (COMISA) may be associated with increased cardiovascular disease risk [12, 13] and worse mental health and quality of life [13, 14] . Although pregnancy may be associated with increased prevalence of both insomnia and OSA [15, 16] , few studies have investigated the co-occurrence of insomnia and OSA during pregnancy, or the effect of COMISA on depression, anxiety and stress during or following pregnancy. Gestational sleep disordered breathing (SDB) often affects pregnant women, ranging from simple snoring to complete cessation of breathing with recurrent airflow interruptions usually accompanied by oxygen desaturation and fragmented sleep (i.e., OSA). SDB may also present as snoring and/or self-reported 'poor sleep quality'). Pregnancy is a particularly vulnerable moment of life where sleep and psychological health often interact, and may perpetuate multiple psychological (e.g., anxiety, stress, depression), and physical consequences (e.g., disturbed metabolism, immunity suppression). These intriguing interactions may also be influenced by a significant increase in body mass index and cardiorespiratory changes due to altered circuitry of several regulatory processes. For instance, neurohumoral changes including those related to central modulation of leptin and ghrelin may increase the likelihood of overweight and obesity, as well as mediate sympathetic activation and cardiac function [16] . These changes may favour increased symptoms of fatigue and exhaustion commonly reported during pregnancy. At the same time hormonal modifications may affect sleep quality and sleep duration. Interestingly, excessive daytime sleepiness and total sleep duration both increase during pregnancy, potentially due to either the deterioration in subjective sleep quality or hormonal changes. This may also result from neuroendocrine functional pathways such as those implicated in the lower progesterone levels. Estrogen-mediated nasopharyngeal edema and rhinitis are common risk factors for gestational SDB. There are also some factors associated with pregnancy that may be protective against OSA. For example, the proneness for a lateral sleep position (in which airway closure is less likely to occur), a reduction in the percentage of rapid-eye-movement sleep (in which airway closure events are more common than in deep sleep), and the rightward shift of the oxyhemoglobin dissociation curve (promoting placental oxygen delivery) may serve as protective factors against exacerbation of gestational sleep apnea [16] . BMI may be indicated as a significant predictor of gestational SDB, accounting for an increase in sleep apnea prevalence from 10.5% in the first trimester to 26.7% in the third trimester [15] . Furthermore, circadian misalignment (i.e., a mismatch between the internal body clock and the environmental light-dark cycle) and chronotype (e.g., an individual's inclination to sleep at a specific time) may affect the circadian timing system and interactions with sleep, psychological, cardiovascular and metabolic outcomes. For example, the evening chronotype is more likely to be associated with sleep onset insomnia, anxiety, and depression in adults and paediatric samples [18, 19] . Interestingly, insomnia, OSA, and circadian misalignment may frequently co-occur in a more complex condition. Among pregnant women, all three factors potentially interact and impair homeostatic stability, either related to sleep or to neurohormonal milieu underpinning daytime function and mood. These important findings have promoted awareness of the link between poor sleep and psychosocial stress during pregnancy [1] . Future research should also explore the interactive role of insomnia, OSA, and circadian misalignment on mental and physical health during pregnancy. Developing a greater understanding of the interactions between these sleep disorders/symptoms may guide more effective treatment approaches that also prevent and improve mental health problems during and following pregnancy. Funding The authors declare that they don't have any financial arrangements or commercial connections. Sleep conditions associate with anxiety and depression symptoms among pregnant women during the epidemic of COVID-19 in Shenzhen The prevalence of psychiatric symptoms of pregnant and non-pregnant women during the COVID-19 epidemic Insomnia in late pregnancy: characterizing phenotypes and identifying associated factors Delayed sleep timing and circadian rhythms in pregnancy and transdiagnostic symptoms associated with postpartum depression Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies Insomnia symptoms during pregnancy: a meta-analysis The role of circadian rhythms in postpartum sleep and mood Do symptoms of depression, anxiety or stress impair the effectiveness of cognitive behavioural therapy for insomnia? A chart-review of 455 patients with chronic insomnia A randomized controlled trial of digital cognitive behavioral therapy for insomnia in pregnant women Developing a successful treatment for co-morbid insomnia and sleep apnoea Obstructive sleep apnea, shift work and cardiometabolic risk A reappraisal on the associations between sleep-disordered breathing, insomnia and cardiometabolic risk Comorbid Insomnia and Sleep Apnea: mechanisms and implications of an underrecognized and misinterpreted sleep disorder Depressive symptoms in comorbid obstructive sleep apnea and insomnia: an integrative review Risk factors for sleep-disordered breathing in pregnancy Sleep disorders in pregnancy Obstructive sleep apnea and depression Evaluation of chronotype among children and associations with bmi, sleep, anxiety, and depression Sleep Extension Study Group Evening chronotype is associated with changes in eating behavior, more sleep apnea and increased stress hormones in short sleeping obese individuals The authors declare to have no conflict of interest.