key: cord-0833371-yfeq3rsq
authors: Pimenta, Inês; Varudo, Rita; Lança, Sara; Gonzalez, Filipe André
title: Exuberant spontaneous pneumothorax, pneumomediastinum, pneumopericardium and subcutaneous emphysema in COVID-19 pneumonia
date: 2021-05-12
journal: BMJ Case Rep
DOI: 10.1136/bcr-2021-243861
sha: b7a0cf6e46f207cdea0a419aa84981ab92224c92
doc_id: 833371
cord_uid: yfeq3rsq

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A 54-year-old man diagnosed with COVID-19 was admitted to the emergency department for increasing shortness of breath following a 2-week history of fever and fatigue. At admission, his chest X-ray showed bilateral patchy infiltrates, he was hypoxemic and noninvasive mechanical was initiated. On hospital day 4, subcutaneous emphysema was noticed and chest CT showed subcutaneous emphysema extending from the cervical region along the arms associated with pneumomediastinum, pneumopericardium and bilateral pneumothorax (figure 1). A chest drain was placed with pneumothorax resolution. However, respiratory failure further deteriorated and invasive mechanical ventilation was started on the next day. The patient was admitted to the intensive care unit (ICU). Due to prolonged ventilation and critical illness myopathy, a tracheostomy was performed after 22 days of invasive ventilation.

On hospital day 25, a right-sided hypertensive pneumothorax requiring decompression complicated the disease course. CT scan revealed a septate hydropneumothorax suggestive of empyema and a pneumatocele on the same side (figure 2). After insertion of another chest drain directed at the septate collection and a course of antibiotics, the patient progressively improved. Repeated CT scan showed a reduction in the size of the hydropneumothorax. After 54 days in the ICU, the patient was transferred to the ward.

Pneumothorax has been reported as a complication occurring during the course of COVID-19 pneumonia in about 1% of hospital admissions and 2% of ICU admissions. 1 Likewise, cases of pneumomediastinum and subcutaneous emphysema have been described in the literature occurring at presentation or during disease course. 2 3 Traditional risk factors for pneumothorax and mediastinal emphysema include tall and thin stature, smoking, chronic lung disease or asthma. However, an association between these features and pneumothorax occurring in patients with COVID-19 has not been established and it seems that the particular pathophysiology of SARS-CoV-2 pneumonia might have a role in such complications. 1 Despite the mechanism remaining unknown, it is speculated that increased alveolar pressure and diffuse alveolar injury make alveoli prone to rupture, then causing air dissection into the mediastinum and subcutaneous tissue. 4 The incidence of pneumothorax is higher in mechanically ventilated patients due to the risk of barotrauma and its estimated occurrence is 15%. 1 However, there are reports of patients with pneumothorax or pneumomediastinum that were only treated with noninvasive ventilation. Structural changes to lung parenchyma in conjunction with episodes of coughing that increase intrathoracic pressure could act as inducing factors. 5 Radiological findings in patients with COVID-19 including the presence of pneumatoceles may be implicated in the pathophysiology of secondary pneumothoraces. 6 Although a rare complication in COVID-19 patients, pneumothorax or subcutaneous emphysema can contribute to profound hypoxemia and complicate clinical evolution. In our patient, recurrent pneumothorax, giant bulla formation and infection were the main challenge in clinical management. These complications can be easily 

diagnosed with imaging techniques, namely, chest X-ray, lung ultrasound and CT, and it is important to be alert to its diagnosis in order to institute adequate and timely treatment.

I do not remember much from my time in the intensive care unit. I remember dreaming a lot and having a lot of vivid nightmares and being difficult to distinguish what was real and not. Now, rehabilitation is a gradual and slow process, but I begin to feel more strength. All in all, I believe that between dreams and nightmares and obstacle was surpassed.

► Pneumothorax, pneumomediastinum and subcutaneous emphysema can occur in COVID-19 pneumonia in the presence or absence of mechanical ventilation and contribute to the profound hypoxemia seen in these patients. ► Radiological findings in patients with COVID-19 include giant bulla formation and pneumatoceles, which may be implicated in the pathophysiology of secondary pneumothorax and pneumomediastinum and its management composes a clinical challenge. ► On clinical suspicion, imaging techniques like chest X-ray, lung ultrasound and chest CT are useful in identifying patients with these complications in order to timely institute appropriate treatment.

Contributors All authors contributed to the writing of the article and were involved with the patient's care. IP was responsible for conception of the article content, intellectual content and drafting of the manuscript. RV contributed to revision of the initial draft. SL participated in conception and design of the article. FAG contributed to preparation of the final manuscript. All authors read and approved the final manuscript.

Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

Competing interests None declared.

Patient consent for publication Next of kin consent obtained.

Provenance and peer review Not commissioned; externally peer reviewed.

This article is made freely available for use in accordance with BMJ's website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

Filipe André Gonzalez http:// orcid. org/ 0000-0002-8539-1092

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Spontaneous pneumomediastinum in COVID-19

Mediastinal emphysema, giant bulla, and pneumothorax developed during the course of COVID-19 pneumonia

Severe acute respiratory syndrome complicated by spontaneous pneumothorax

Pneumothorax in COVID-19 disease-incidence and clinical characteristics

Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study