key: cord-0832608-vxcp0pni
authors: Suwanwongse, Kulachanya; Shabarek, Nehad
title: Bilateral Popliteal Vein Thrombosis, Acute Pulmonary Embolism and Mild COVID-19
date: 2020-10-28
journal: Cureus
DOI: 10.7759/cureus.11213
sha: 9efef8271286611e529618cf9c17326d353fb7d8
doc_id: 832608
cord_uid: vxcp0pni

In 2020, the coronavirus disease 2019 (COVID-19) has become a global health disaster. Patients with COVID-19 have variable clinical features and unpredictable prognoses; the infectious complication may occur in many organs, causing a broad spectrum of symptoms and severity. Pulmonary embolism (PE) is a fatal urgent complication, which may occur following a severe infection. While the pathogenesis of PE in COVID-19 remains uncertain, it has mainly occurred in patients with severe disease. PE, as an initial presentation of COVID-19 in a patient with mild diseases, is rare and understudied. Here, we describe a young woman with mild COVID-19 illness and no significant risk factors for PE, except obesity, but had developed bilateral popliteal vein thrombosis and submassive PE. Our case emphasizes that thrombotic complications can occur in any COVID-19 patients regardless of the disease severity, questioning the role of preventive anticoagulants in mild COVID-19 cases with certain risk factors.

Novel coronavirus disease 2019 (COVID-19) has now become a fatal pandemic affecting millions worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the third identified human pathogenic β-coronavirus, following severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) [1] . Like SARS-CoV, SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 (ACE-2) receptors causing a spectrum of diseases varying from flu-like illnesses to lethal pneumonia [1, 2] . For an unclear reason, thrombosis is the major coagulopathy related to SARS-CoV, and SARS-CoV-2, while bleeding diathesis is more common among MERS-CoV [3] . Pulmonary embolism (PE) is a common fatal thrombotic complication associated with severe COVID-19 [4, 5] . However, there is limited evidence regarding PE in mild COVID-19 patients. Herein, we share our institutional experience -a young, healthy woman who developed submassive PE and bilateral popliteal vein thrombosis following mild COVID-19.

An obese 31-year-old woman came to our hospital because of worsening dyspnea. She reported progressive exertional dyspnea associated with chest pain for two days but denied having a fever or any other pulmonary symptoms. The patient endorsed painless swelling of the right leg four days prior. She denied previous medical diseases and was not taking any medication or oral contraceptive pills. None of her family members had a history of vascular thrombosis. The patient denied recent immobilization, including long-distance travel. Her vital signs were: heart rate 110 bpm, blood pressure 135/77 mmHg, body temperature 36.8 0 C, respiratory rate 30 per minute with oxygen saturation of 92% on room air. Her blood test results were demonstrated in table 1; briefly, she had mild leukocytosis, lymphocytopenia, and elevated D-dimer and pro-BNP. Her electrocardiogram (EKG) illustrated normal sinus rhythm, S1Q3T3 pattern, and anterolateral T wave inversion (right ventricular strain) ( Figure 1) . Chest X-ray (CXR) had no significant infiltration (Figure 2 , left). Computed tomography (CT) pulmonary angiography showed prominent bilateral pulmonary emboli and peripheral alveolar infiltrations (Figure 2, right) . Doppler vascular sonography of bilateral lower extremities found occlusive intravenous thrombosis of bilateral popliteal veins. 

She was started on a heparin drip, admitted to the medical intensive care unit, and received catheterdirected thrombolysis for the treatment of PE. She did not receive any specific COVID-19 medication. On admission day 4, her dyspnea and hypoxia were resolved, and she was discharged on a 6-month course of oral anticoagulant.

Previous scoping review estimated that 20% of critically ill COVID-19 patients developed venous thromboembolism (VTE); the development of VTE was also found to adversely impact patients' outcomes and was associated with high COVID-19 mortality [6] . However, there is a lack of data regarding VTE in mild COVID-19. Ullah et al. recently reported a 59-year-old woman with multiple comorbidities admitted due to COVID-19 pneumonia and hypoxemia requiring supplemental oxygen therapy. Before planned discharge, the patient suddenly developed worsening hypoxemia and was found to have massive PE; she received therapeutic enoxaparin with clinical improvement and was discharged home [7] . We described a young woman presented with worsening dyspnea and was found to have mild COVID-19 and submassive PE.

The mechanisms underlying PE in COVID- 19 have not yet been elucidated. Theoretically, COVID-19 may disturb all dimensions of Virchow's triad: endothelial injury, hypercoagulability, and venous stasis ( figure 3) . SARS-CoV-2 can directly injure endothelial cells by binding to its functional ACE-2 receptors. Also, the virus can lead to hypercoagulable states via abnormal activation of immune cells, causing hyper-inflammatory responses, aberrant anticoagulant production, and detrimental immunothrombosis [8] . Hypoxemia from SARS-CoV-2 pneumonia further leads to vasoconstriction and venous stasis, aggravating the pro-thrombotic states. Besides, sick patients are likely to have dehydration and decrease mobility. The occurrence of PE even in mild COVID-19 raises the question of whether we should provide prophylactic anticoagulation use in selected mild COVID-19 cases.

Mild COVID-19 illness may associate with an increased risk of thrombosis. More research is needed to verify our hypothesis and determine if the development of VTE and PE is associated with worsening COVID-19 outcomes. A study exploring the use of anticoagulants in mild COVID-19 cases with certain risk factors, such as malignancy and immune-mediated diseases, will be worthwhile.

Human subjects: All authors have confirmed that this study did not involve human participants or tissue.

In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

A new coronavirus associated with human respiratory disease in China

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

Incidence of venous thromboembolism in hospitalized patients with COVID-19

Thrombosis risk associated with COVID-19 infection. A scoping review

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis