key: cord-0828822-u5wyn2hq authors: Shah, Dipal; Koumans, Helene; Johnson, Kimberly; Leon, Leoh N; Ganti, Latha title: Abnormal Bedside Ultrasound Findings in a Complex Patient With Kawasaki Disease date: 2021-08-11 journal: Cureus DOI: 10.7759/cureus.17112 sha: b9a45f547d11c7c006992ed68243939a5d9b8c60 doc_id: 828822 cord_uid: u5wyn2hq We herein report a case of an 18-year-old female with Kawasaki disease who presented to the emergency department with epigastric abdominal pain and was subsequently found to have free fluid present in her abdomen visualized on bedside Focused Assessment with Sonography for Trauma (FAST) exam. Kawasaki disease is an acute vasculitis syndrome that primarily affects children and can have serious complications such as coronary artery aneurysms. The use of ultrasound in emergency departments is rapidly increasing, with the FAST being one of the most commonly performed bedside ultrasound examinations. FAST exams are most commonly performed in trauma patients as well as being part of the Advanced Trauma Life Support (ATLS) protocol. However, this case demonstrated that the FAST exam can also have application in other clinical scenarios and patient presentations where there is clinical suspicion of free intra-abdominal fluid. Kawasaki disease (KD), also termed mucocutaneous lymph node syndrome, is an acute vasculitis syndrome primarily affecting small to medium-sized arteries of children under five years old. Although the etiology is unknown, patients with KD frequently present with fever, swelling of the hands and feet, rash, swollen glands in the neck, and irritation of the mouth, lips, throat, and eyes. KD causes inflammation in artery walls, and serious complications include coronary artery dilations and aneurysms (CAA). KD is a leading cause of acquired heart disease in the United States and the leading cause of pediatric ischemic heart disease, though a standard treatment of intravenous immunoglobulin and aspirin has been developed to stifle the development of coronary artery abnormalities [1] . Mild dilation or ectasia of the coronary arteries occurs in up to approximately 40% of patients, and coronary artery aneurysms occur in 15-25% of untreated patients. The standard treatment of intravenous immunoglobulin and aspirin, an anti-platelet medication, significantly decrease the development of coronary artery complications. Additionally, coronary artery bypass grafting (CABG) has proven safe and effective for KD-associated coronary heart disease. The subsequent report describes a case of a patient presenting with epigastric pain and significant free fluid upon conducting a Focused Assessment with Sonography for Trauma (FAST) scan, which assesses the pericardium and three spaces within the peritoneal cavity for fluid, and has proven to be quite sensitive. The symptoms of the case were of particular note due to the history of KD, CAA, and CABG. An 18-year-old female with history of KD, coronary artery aneurysms, and coronary artery bypass grafting (CABG) presents to the emergency department by EMS reporting abdominal pain starting earlier this morning. The patient describes the abdominal pain as epigastric radiating to her right shoulder and worsened with deep inspiration. The pain has been worsening throughout the day. She also endorses nausea. She denies vaginal bleeding and reports that her last menstrual period was approximately one month ago. She endorses a history of bulimia, and reports forceful vomiting episodes every day for the past year. Otherwise, the patient denies fever, cough, recent illness, trauma or injury. She notably has a history of KD as a child resulting in coronary artery aneurysms and requiring CABG surgery at age 12. She is currently taking warfarin and aspirin. Physical exam is remarkable for blood pressure of 99/69 mmHg and heart rate of 98 beats per minute, 1 remaining vital signs within normal limits. On exam, the patient is in no acute distress. The exam is significant for diffuse abdominal tenderness with voluntary guarding. Due to significant abdominal tenderness on initial physical exam, bedside FAST scan was performed, which was found to be positive, demonstrating a significant amount of free fluid in the right upper quadrant, left upper quadrant, and suprapubic views (Figures 1, 2 ). Other workup was remarkable for anemia with a hemoglobin of 8.0 g/dl and negative pregnancy test. Surgery was consulted and computed tomography angiography (CTA) of the chest, abdomen, pelvis were performed emergently due to concern for internal bleeding. CTA imaging demonstrated no acute findings of the aorta, and coronary artery aneurysms at the right coronary artery (RCA) and left anterior descending artery (LAD). Non-contrast CT of the abdomen and pelvis demonstrated free fluid (Figure 3 ). Prothrombin complex concentrate (PCC) and tranexamic acid (TXA) were given due to concern for bleeding on anticoagulation. Due to ongoing concern for internal bleeding along with the patient's risk factors, the patient was admitted to the surgical intensive care unit (ICU) for further management. In the ICU, the patient was transfused 2 units of packed red blood cells. Serial hemoglobin checks and abdominal exams were performed with a plan for diagnostic laparoscopy if hemoglobin decreased. However, the patient's hemoglobin remained stable, abdominal pain improved, and the patient was eventually discharged to home the following day with close follow-up. The case presented with abdominal pain and a history of pediatric KD resulting in coronary artery aneurysms (Figure 4) . The patient was already taking warfarin and aspirin. Aspirin is a standard treatment for KD [2] [3] [4] , and there is ongoing inquiry into the safety and efficacy of warfarin as an accompanying treatment [5, 6] . In addition to the patient's initial physical exam, a bedside FAST scan was emergently performed upon the patient's arrival via ambulance, after which a CTA was performed out of concern for internal hemorrhage, which may occur in KD patients secondary to a ruptured aneurysm. The FAST scan indicated a significant amount of free fluid, and prothrombin complex concentrate (PCC) and tranexamic acid (TXA) were administered due to concern for internal bleeding in a patient on anticoagulants. At present, there has not been considerable investigation of the use of FAST scans in cases of KD or those with history of KD. Further research has been conducted in adjacent fields as a result of the KD-like symptoms of the rare multisystem inflammatory syndrome in children reported as a post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), now termed pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) [7] . FAST scans have demonstrated sensitivities between 85% and 96% and specificities above 98%. Additionally, FAST scans can be conducted in fewer than five minutes and decrease time to surgical intervention [8] . Further study should be done of the benefits and risks of FAST scans in cases presenting abdominal pain and with a history of KD and coronary artery aneurysm. In this case, the FAST scan was critical in the identification of significant free fluid, which allowed for expedient follow-up laboratory work and treatment. Additional study of FAST scans with similar case presentations should be conducted to determine follow-up interventions necessary. Prompt identification of free fluid and possible internal hemorrhage is critical in timely administration of follow-up treatment in the emergency department. Untreated internal bleeding, which may be exhibited in KD patients or patients with a history of KD, may result in organ failure, seizure, coma, and death. The performance of a FAST scan allowed for expedient identification of free fluid, subsequently allowing for necessary laboratory work and treatment. Thus, particularly among patients with a history of KD and presenting with abdominal pain, further study should be conducted on the performance of FAST scans in the determination of necessary intervention. . Based on the information provided and attested as true, the research plan described does not require IRB oversight. This is because you are either a) not engaging in research with human subjects as defined by federal regulations; b) engaging in research with human subjects deemed excluded from IRB oversight per 45CFR46.102(l) OR c) engaging in research with sufficient human subject protections in the design to meet one or more IRB exemption criteria set forth in 45CFR46.104. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. History and future of treatment for acute stage Kawasaki disease Effect of different doses of aspirin on the prognosis of Kawasaki disease Efficacy between low and high dose aspirin for the initial treatment of Kawasaki disease: current evidence based on a meta-analysis Safety and efficacy of warfarin therapy in Kawasaki disease Warfarin plus aspirin or aspirin alone for patients with giant coronary artery aneurysms secondary to Kawasaki disease 6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study Focused assessment with sonography for trauma This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. 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