key: cord-0826325-eblu1oko authors: de Lusignan, Simon; Alexander, Helen; Broderick, Conor; Dennis, John; McGovern, Andrew; Feeney, Claire; Flohr, Carsten title: The epidemiology of eczema in children and adults in England: A population‐based study using primary care data date: 2020-11-26 journal: Clin Exp Allergy DOI: 10.1111/cea.13784 sha: 4606f8221123f049ad8acea2d8251f7923778624 doc_id: 826325 cord_uid: eblu1oko BACKGROUND: Whilst eczema is a common inflammatory skin condition, we lack contemporary estimates of disease incidence and prevalence across the lifespan. OBJECTIVE: To estimate the incidence and prevalence of eczema in children and adults in England and variation by sociodemographic factors (sex, socio‐economic status, ethnicity, and geography). METHODS: We used the Royal College of General Practitioners Research and Surveillance Centre primary care research database of 3.85 million children and adults registered with participating general practitioner practices between 2009 and 2018 inclusive. Eczema incidence was defined as the first‐ever diagnosis of eczema recorded in the primary care record, and eczema prevalence was defined as fulfilment of criteria for active eczema (two eczema records appearing in the primary care record within any one‐year period). RESULTS: Eczema incidence was highest in infants younger than 1 year (15.0 per 100 person‐years), lowest in adults aged 40–49 (0.35 p/100 person‐years), and increased from middle age to a second smaller peak in people 80 years or older (0.79 p/100 person‐years). Eczema prevalence was highest in children aged 2 (16.5%) and lowest in adults aged 30–39 (2.8%). Eczema incidence was higher in male infants (<2) and male adults older than 70; for all other ages, incidence was higher in females. Eczema was more common in Asian and black ethnic groups than in people of white ethnicity. Higher socio‐economic status was associated with a greater incidence of eczema in infants younger than 2, but the reverse was seen for all other age groups. Both incidence and prevalence of eczema were greater in urban settings and in North‐West England. CONCLUSIONS AND CLINICAL RELEVANCE: Eczema has a bimodal distribution across the lifespan. We observed differences in incidence and prevalence of eczema by ethnicity, geography, sex, and socio‐economic status, which varied in magnitude throughout life. Eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that affects around 200 million people world-wide. 1, 2 The incidence of eczema has risen significantly over past decades, in particular in high-income countries. 3 It most commonly develops in the first year of life, although onset can occur at any age. 4, 5 Eczema usually follows a chronic relapsing-remitting course, and maintaining disease control may require the use of ongoing treatment. 6 Whilst many eczema-affected children will have resolution or improvement by late childhood, 4 a substantial proportion of people will have ongoing eczema into adulthood, and flare ups can occur even after long periods of remission. 5, 7 Itch, discomfort, and visible skin lesions result in disturbed sleep and social embarrassment and affect the quality of life of those affected and their families. 8 When moderate to severe, the psychological impact in children and adults is often profound. [9] [10] [11] In the United Kingdom (UK), prevalence estimates vary widely, especially in adults, and contemporary data on the factors influencing eczema development, such as urban environments, are lacking. Recent questionnaire-based studies suggest prevalence rates of 2.5%-15% in adults. 12, 13 Given that the majority of eczema patients are seen and treated in primary care in the UK, databases of electronic health records from general practitioner (GP) practices provide a rich data source from which epidemiological analyses can be derived. 14 In a recent study using the UK Clinical Practice Research Datalink (CPRD), approximately 500,000 people were identified as having eczema between 1998 and 2015, which scales to a UK prevalence of 10%. 15 However, this study was designed to assess cardiovascular outcomes in eczema not prevalence per se and only assessed the adult population. Another CPRD study was conducted to examine the incidence of eczema in children between 1997 and 2015 and found the highest incidence in those younger than 2 years of age (15.9 [95% CI 15.7-16.1] per 100 person-years in males and 11.7 [11.5-11.8] in females) and the lowest incidence in those 5 years of age and older (0.4 [0.3-0.4] per 100 person-years in males and 0.5 [0.5-0.5] in females). 16 In this retrospective population-based study, we set out to provide a contemporary description of the incidence of new onset eczema, and the prevalence of active eczema, in children and adults in England and how these estimates vary by sex, socio-economic status, ethnicity, and geography. We used the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) database to provide a population-based sample to calculate eczema incidence and prevalence estimates. The RCGP RSC cohort is drawn from a large network of GP practices distributed across England, providing a representative sample of the English population. 17 Over the entire study period, the RCGP RSC database contained data from 3.85 million people registered with 293 general practitioner (GP) practices across England. The RCGP RSC database contains demographic data (including age, sex, ethnicity, socio-economic status [SES] , and rurality), clinical diagnoses, anthropometric measurements (eg body mass index [BMI] , laboratory test results and prescriptions, recorded using the Read coding system (a widely used, standardized thesaurus of clinical terms). 18 UK general practice lends itself to this type of study because it is a registration-based system (each patient can only be registered with a single GP), it has been computerized since the 1990s, and pay-for-performance targets introduced in 2004 have resulted in consistent, high-quality clinical data entry relating to chronic disease. 19 Studies using RCGP RSC data have been published across a wide range of diseases, including SARS-CoV-2, liver disease, atrial fibrillation, asthma, and diabetes. 20-24 All adults and children registered with practices contributing data to the RCGP RCS database between 1 January 2009 and 1 January 2019 were eligible for inclusion in the study. Individuals required at least one year of follow-up in RCGP RSC, unless under 1-year-old. People who opted out of record sharing were excluded (approximately 1.8% of the adult population). The full protocol for the study was pre-specified and has been previously published. 25 Individuals with eczema were identified using a validated algorithm developed for use with UK electronic health records 26 and applied in recent UK studies in eczema. 15, 16 The positive predictive value of this algorithm is 90% (95% Confidence interval (CI) 80%-91%) in children and 82% (95% CI 73%-89%) in adults. 26 In brief, eczema is identified by the presence of one diagnostic code and at least two eczema-related treatment codes on separate days. Active eczema was defined as the later of two eczema records appearing within any one-year period by Silverwood et al 15 in their study of cardiovascular outcomes in atopic eczema (AE) in primary care. Active AE was then assumed to last for 1 year, unless another AE record appeared, in which case its duration was prolonged for an additional 1-year period. 15 We utilized this approach but to signify the onset of active eczema we used the first of two codes (rather than the second) within 1 year as this has shown good agreement with physician-confirmed onset. 26 Eczema incidence and prevalence were stratified by age in children (0-17 inclusive, by year) and adults (age categorized as 18-29, 30-39, 40-49, 50-69, 60-69, 70-79, 80+). To examine variation across other sociodemographic factors when stratified by age, we also defined broader age group categories (<2, 2-11, 12-17, 18-49, ≥50). Ethnicity was extracted from the primary care record and grouped into major ethnic groups: white, black, Asian, mixed, and others. 27 Socio-economic status (SES) was defined using the official national deprivation measure: index of multiple deprivation (IMD). 28 This was calculated at the point of data extraction, using patient postcode, with the resultant scores stratified by deprivation quintile according to the national distribution. Rural/urban classification was defined by patient postcode, using the 2011 Office for National Statistics rural-urban classification. 29 2.5.1 | Incidence of eczema Incident cases were defined as individuals with a first-ever diagnosis of eczema during the study period. Patients with a diagnosis of eczema prior to the study period were excluded. To increase certainty that an eczema diagnosis was incident, individuals with a diagnosis within one year of registering with a practice were excluded from the incident analysis, unless younger than 1-year-old. We calculated age group stratified incidence rates (per 100 person-years) over the study period, with further stratification within each age category by sex, ethnicity, quintile of IMD, urban/rural classification, and geographical region, by dividing the number of incident patients by the sum of person-years of follow-up for the total eligible population over the period of interest. Multivariable-adjusted incidence rate ratios (aIRR) controlling for age category, sex, ethnicity, quintile of IMD, urban/rural classification, and geographical region were calculated using Poisson regression. We estimated the prevalence of active eczema, overall and by age Using data from the most recent year (2018), we estimated the age group stratified prevalence of eczema by sociodemographic factors (sex, ethnicity, IMD, urban/rural classification, and geographical region; and the unadjusted and multivariable adjusted odds of prevalent eczema for the same factors using logistic regression). All statistical analyses were performed using R statistical package software version 3.4.1 (R Core Team, Vienna, Austria, 2017). Study approval was granted by the Research Committee of the RCGP RSC. The study did not meet the requirements for formal ethics board review as defined using the National Health Service (NHS) Health Research Authority research decision tool (http://www.hradecis ionto ols.org.uk/resea rch/). The study was conducted following the RECORD (REporting of studies Conducted using Observational Routinely collected Data) guidelines. 30 The study population consisted of 3,851,055 children and adults with valid clinical data and no history of eczema prior to 01/01/2009 (Flowchart S1). A total of 174,606 people developed incident eczema over the study period. In children, the incidence of eczema is highest in male infants, with a peak incidence of 17.4 (95% CI 17.1, 17.6) per 100 person-years in infants younger than one year ( Figure 1A , Table S1 ). From age 2 onwards, the incidence is higher in females than males and falls progressively up to the age of seven for both sexes, after which incidence plateaus up to age 18. In adults, incidence is relatively stable from ages 18-49, after which there is a steady increase in incidence for both sexes ( Figure 1B , Table S1 ). This increase is most marked in males, resulting in a greater incidence of eczema in males compared to females from age 70. Over 2009-2018, we observed a gradual decrease in the incidence of eczema in both adults and children ( Figure S1 ). In infants, the incidence of eczema recorded in primary care was higher in those of higher socio-economic status (IMD quintiles 4 and 5), but in those older than two years of age the trend was reversed and persisted throughout adulthood (Table 1) . Compared with people of white ethnicity, across the lifespan people of Asian ethnicity have a higher incidence of eczema. People of black and, to a lesser extent, mixed ethnicity also have a higher incidence of eczema than people of white ethnicity, up to age 50. A higher incidence was observed in urban than rural areas for all age groups (Table 1 ). The prevalence of active eczema is greatest in children aged 1-4 and then decreases with increasing age with a nidus in the fourth and fifth decades of life ( Figure 2 , Table S2 ). Active eczema then increases again in prevalence with increasing age, almost returning to the peak childhood prevalence in those aged 80 years and older. Over the decade we studied, we found a slight decrease in prevalence of active eczema in children but little change in prevalence in adults ( Figure S2 ). In children, overall prevalence of active eczema is similar in males and females, but in adults, active eczema is more prevalent in females (Tables 2 and 3 ). In children and adults, active eczema is more prevalent in those of Asian, black, and mixed ethnicity than in those of white ethnic background. Across the lifespan, a higher prevalence is also found in the most deprived IMD quintile compared with all other IMD quintiles. In addition, a higher prevalence is found in urban than rural areas across the lifespan (Tables 2 and 3 ). The crude incidence of eczema is highest in the North-West, London, and the West Midlands across the lifespan (Table S3 ). After adjustment for age, sex, SES, and ethnicity, the higher incidence in the North-West becomes even more pronounced ( Figure 3A and Table S4 ). Similarly, the highest prevalence rates for active eczema are in London, the North-West, and the West Midlands (Table S5) , even after adjustment for confounding factors ( Figure 3B and Table S6 ). When analysed separately in children and adults, incidence and prevalence are highest in the North-West and West for both groups (Tables S4 and S6 ). In a large population-based cohort of more than 3.85 million people in England, we found that the incidence and prevalence of eczema had a bimodal age distribution. The highest incidence of eczema was seen in children younger than one (incidence rate 15.0 per 100 person-years), with a steady decrease during childhood and early adulthood and a subsequent steady increase after age 50. We also observed striking differences in the incidence and prevalence of eczema by sex, socio-economic status, ethnicity, and geography. In agreement with our study, a recent UK analysis of children in primary care found the highest rates of incident eczema in infancy but that eczema was also common across childhood. 16 To the best of our knowledge, our study is the first to provide population-based UK data on eczema incidence in adults. Our data for prevalent eczema overall AE prevalence of 7%-14% in childhood. 31 Our reported prevalence in adults (4.3%) is likely lower than that reported by Abuabara et al (5%-12%) due to the different time period and sampling strategies used as well as our case definition, as we limited prevalent cases to those with active disease. 15 The decrease in eczema incidence and prevalence throughout childhood and adulthood may be partly due to maturation of the skin barrier properties. [32] [33] [34] A gradual decline in water holding properties of the skin barrier in older age would also be an explanation for the second peak in eczema incidence seen in older adults, but this needs further investigation. 35-37 The notable differences in the incidence of childhood eczema by sex, with an increased incidence in male infants younger than 2 and female children thereafter, are in concordance with a recent study using a different UK primary care dataset and previous Scandinavian population-based studies. 16, 38, 39 Comparable differences by sex have also been seen in the childhood prevalence of allergic rhinitis and asthma during childhood. 40 In adults, the increased incidence observed in older males compared with females was previously reported in Japanese hospital-based patients, 32,41 but to our knowledge not in a population-based setting. Previous studies evaluating the relationship between atopic conditions and SES have, in general, suggested a higher prevalence of eczema in less deprived SES groups. 42 In contrast, we found a higher incidence of eczema in less deprived SES groups (IMD quintiles 4 and 5) only in infants, a finding consistent with other recent UK primary care-based data. 16 Across the rest of the lifespan, less deprived SES was consistently associated with a lower rate of incident eczema. Differences with previous studies may relate to variation in setting and in methodology, with a particular strength of this analysis being the comprehensive adjustment for other sociodemographic factors and geography. Consistent with our study, US data suggest that people of Asian and black ethnicity are substantially more likely to attend medical TA B L E 1 Adjusted incidence rate ratios of new-onset eczema by age category and sociodemographic characteristics, 2009-2018 inclusive in children (n = 913,606) and adults (n = 3,149,160) a The only previous data on the geographical distribution of eczema in England are the 1958 British Cohort Study, which identified the North Midlands, Eastern region, London, and Southern region, as areas of higher prevalence. 47 Direct comparisons with our results are limited by differences in geographical boundaries, socio-economic changes, and differences in the population samples studied. Variation in eczema prevalence by geographical area has also been seen in other countries. 44 The environmental factors that increase the risk for eczema have yet to be fully elucidated, but ultraviolet radiation exposure, lower air temperature, and higher use of indoor central heating have all been linked to higher eczema rates, 48, 49 and this offers a potential explanation for the higher rates seen in North-West England. Consistent with our study, a higher incidence and prevalence of eczema in urban areas have been seen in previous studies of eczema world-wide 44, 48, 50 and has been linked to differences in air pollution and heavy road traffic. 2, 51, 52 A similar pattern has also been seen in the distribution of allergic rhinitis. 53 Key strengths of this study include our use of a large primary care network to capture eczema diagnoses using a previously validated algorithm. The distribution of the network and variety of the contributing GP practices has enabled us to provide novel insight into geographical and urban-rural variation in eczema. Our high level of data capture on SES and ethnicity in this large population and the fact that the majority of eczema treatment is undertaken in primary care in the UK are also important strengths. Several limitations are worth noting. First, a diagnosis of eczema requires presentation to primary care, and we will therefore have missed minor and subclinical disease, leading to an underestimate of eczema incidence and prevalence. We were unable to determine whether this issue has a differential effect by sex and ethnicity. Similarly, we cannot be certain that the first recorded eczema diagnosis in the primary care record is an accurate reflection of initial disease onset in all cases, although this was mitigated by our study design which excluded individuals with an eczema diagnosis within 1 year of registering with a general practice. Second, our case definition requires prescriptions for eczema treatments, some of which are available over the counter. People purchasing all their treatments directly from a pharmacy will therefore be missed by our approach. We were unable to examine the association between familial history of atopic or allergic disease and eczema onset, as this is not well Our results provide timely information on the epidemiology of eczema in the UK and highlight the need for additional studies to more fully understand the pathogenesis of eczema, as well we environmental and ethnicity-related factors that may drive differences in disease burden. In particular, more in-depth evaluation of variation in incidence rates of eczema across different ethnic Abbreviation: IMD, index of multiple deprivation. a Additional age category split (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) was added post hoc due to the marked change in disease prevalence across this age group ( Figure 3A) . b IMD data were not available for n = 9258. c Ethnicity data were not available for n = 192,432. Corroborations of our findings in other populations would also be of great interest, as would investigation of the association between AD incidence and prevalence and environmental factors such as climate. Furthermore, our study suggests many well-used diagnostic criteria for eczema may require refinement given their inclusion of early age of onset in the diagnosis, 54 as use of this definition will exclude the large number of cases of adult-onset eczema we identified. It will also be important to examine the causes of true adult-onset eczema, as this may be genetically and immunologically distinct from eczema that starts in earlier life. In summary, our study uses a large English primary care database to show that eczema is not just a condition of childhood, highlighting a bimodal age distribution of disease with peaks in infants and older adults. There are considerable differences in eczema incidence and prevalence by ethnicity, sociodemographic characteristics, and geography, demonstrating the need to consider these factors when assessing health needs. Researchers wishing to directly analyse the patient-level pseudonymized data will be required to complete information governance training and work on the data from university secure servers. Patient-level data cannot be taken out of the secure network. https://orcid.org/0000-0003-4884-6286 Atopic dermatitis: racial and ethnic differences New insights into the epidemiology of childhood atopic dermatitis Atopic dermatitis: global epidemiology and risk factors The natural course of atopic dermatitis from birth to age 7 years and the association with asthma Characterization of different courses of atopic dermatitis in adolescent and adult patients Atopic dermatitis Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence: a prospective cohort study The burden of atopic dermatitis: summary of a report for the National Eczema Association Emotional dysfunction, child-family relationships and childhood atopic dermatitis Mental health comorbidity in patients with atopic dermatitis The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries Epidemiology of atopic dermatitis in adults: results from an international survey Atopic dermatitis prevalence -UK. n/a Severity distribution of atopic dermatitis in the community and its relationship to secondary referral Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study Incidence and sociodemographic characteristics of eczema diagnosis in children: a cohort study Royal College of General Practitioners Research and Surveillance Centre (RCGP RSC) sentinel network: a cohort profile Defining datasets and creating data dictionaries for quality improvement and research in chronic disease using routinely collected data: an ontology-driven approach The use of routinely collected computer data for research in primary care: opportunities and challenges Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK The impact of therapy on the risk of asthma in type 2 diabetes Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study Incidence, demographics, and clinical characteristics of diabetes of the exocrine pancreas (Type 3c). A Retrospective Cohort Study Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care Epidemiology and management of atopic dermatitis in England: an observational cohort study protocol Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK Ethnicity recording in primary care computerised medical record systems: an ontological approach Department for Communities and Local Government A unified approach to interpreting model predictions The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement Clinical onset of atopic eczema: results from 2 nationally representative British birth cohorts followed through midlife Atopic dermatitis in older adults: a viewpoint from geriatric dermatology Atopic Dermatitis: Pathophysiology Atopic disease in childhood The content of free amino acids in the stratum corneum is increased in senile xerosis Filaggrin in atopic dermatitis Atopic dermatitis in the elderly Incidence trends of atopic dermatitis in infancy and early childhood in a Nationwide Prescription Registry Study in Norway Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology Incidence of lower respiratory tract infections and atopic conditions in boys and young male adults: Royal College of General Practitioners Research and Surveillance Centre Annual Report Clinical characteristics, treatments, and prognosis of atopic eczema in the elderly A systematic review of socioeconomic position in relation to asthma and allergic diseases In the United States, Blacks and Asian/Pacific Islanders are more likely than whites to seek medical care for atopic dermatitis Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations Filaggrin gene mutations in African Americans with both ichthyosis vulgaris and atopic dermatitis Is there a geographical variation in eczema prevalence in the UK? Evidence from the 1958 British Birth Cohort Study Climatic factors are associated with childhood eczema prevalence in the United States Global associations between UVR exposure and current eczema prevalence in children from ISAAC phase three Adult eczema in Italy: prevalence and associations with environmental factors Linking air pollution to atopic dermatitis The impact of airborne pollution on atopic dermatitis: a literature review Conurbation, urban, and rural living as determinants of allergies and infectious diseases: Royal College of General Practitioners Research and Surveillance Centre Annual Report Working Party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis Additional supporting information may be found online in the Supporting Information section The epidemiology of eczema in children and adults in England: A population-based study using primary care data