key: cord-0824247-74coip04 authors: Lechien, Jerome R.; Hsieh, Julien W.; Ayad, Tareck; Fakhry, Nicolas; Hans, Stephane; Chiesa-Estomba, Carlos M.; Saussez, Sven title: Gustatory dysfunctions in COVID-19 date: 2020-06-23 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06154-w sha: ac5b5bdaf74eb5307454ae7ed81637a2d3c0587e doc_id: 824247 cord_uid: 74coip04 nan Since the outbreak of the pandemic, a particular attention has been paid to loss of smell, leaving out, in many studies, gustatory dysfunction. However, in clinical practice, COVID-19 patients report a significant impact of gustatory dysfunction in their quality of life. They typically report that things "tasted like cardboard". As proposed by Dr Bigiani, we believe that gustatory dysfunction, defined as the impairment of salty, sweet, bitter and sour, could be related to the virus spread into the nerve ending of the taste buds of the oral cavity. Pure taste disorders are rare and represent only 5% of specialized smell and taste consultation [3] . Upper respiratory tract infection is one of the most frequent suspected etiology in these cases, but remains largely under investigated [3] . In the particular case of COVID-19, ACE2 receptors has been identified in the oral cavity in humans with high expression level in the tongue [4] , supporting the hypothesis that viral infection and inflammatory response may lead to disruption of saliva composition, normal taste transduction or the continuous renewal of taste buds [5] . Moreover, the virus is known to present a neurotropism, which may contribute to olfactory and gustatory dysfunction [6] and some neurological manifestations [7] . It could be possible that central lesions, caused by propagation of the virus through the olfactory pathways, lead to taste dysfunction. There is many overlapping brain areas between taste and olfactory system. One of them is the frontobasal regions, which is close to the olfactory bulbs that also express ACE2 receptors in their vascular pericytes. Inflammatory damage to this region may alter both senses, namely taste and olfactory function. The neurological damage caused by the virus is also supported by the findings of our last study, in which 20% of COVID-19 patients with anosmia did not recover within 2-month following the onset of olfactory dysfunction [8] . The lack of recovery of both taste and smell after weeks or months may support the occurrence of neurological damage due to extensive inflammation in these regions. Currently, there are few studies investigating the assessment of taste with electrophysiological or psychophysical tools. The prevalence of self-reported taste dysfunction, defined as altered perception of salty, sweet, bitter or/and sour, could reach 56.4% of patients [9] . However, we are aware that selfreported taste dysfunction might be unreliable and could be often confounded with loss of aroma perception, which is normally detected by the olfactory system. In contrast, patients who report having an intact sense of taste, usually do not have a deficit in taste function [10] . Despite the clear need for formal testing rather than self-reporting, we could hypothesize that at least half of the patients with COVID-19 should have an intact gustatory function. The letter of Dr Bigiani and the current patient-reported outcome questionnaire findings of the literature [10, 11] support the need to conduct future studies using at least psychophysical or electrophysiological taste evaluation by using Taste strips or electrogustometry [12] in COVID-19. The study of recovery rate of gustatory function is still important and has to be considered in these studies according to the substantial number of patients who report this issue in clinical practice. Future studies have to be carefully designed to discriminate smell, taste and altered aroma perception, which may be confounded by a large number of patients. Gustatory dysfunctions in COVID-19 patients: possible involvement of taste renin-angiotensin system (RAS) Olfactory and gustatory dysfunctions as a clinical presentation of mildto-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa Inflammation and taste disorders: mechanisms in taste buds Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review Severity of anosmia as early symptom of COVID-19 infection may predict lasting loss of smell Loss of smell and taste in 2013 European patients with mild to moderate COVID-19 Accuracy of self-report in detecting taste dysfunction Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study Changes in electrogustometry thresholds, tongue tip vascularization, density and form of the fungiform papillae in smokers Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors.