key: cord-0823108-b2sqfhw1
authors: Singh, Romil; Shiza, Saher T; Saadat, Rabeea; Dawe, Manal; Rehman, Usama
title: Association of Guillain-Barre Syndrome With COVID-19: A Case Report and Literature Review
date: 2021-03-11
journal: Cureus
DOI: 10.7759/cureus.13828
sha: c94bdf0660e5c395220056ec285d79e41c61799f
doc_id: 823108
cord_uid: b2sqfhw1

There is growing evidence of neurological involvement in patients with coronavirus disease 19 (COVID-19), suggesting that Guillain-Barre syndrome (GBS) can also occur with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a neurological complication. Herein, we describe a unique case of a 45-year-old male who manifested with sudden onset progressive symmetric ascending paralysis leading to quadriplegia one week after developing fever, cough, and dyspnea. On examination, he had areflexia in lower limbs and hyporeflexia in upper limbs. Hypoesthesia to fine touch and vibration distal to calf was noted. His reverse transcriptase-polymerase chain reaction (RT-PCR) was positive for COVID-19, and his cerebrospinal fluid (CSF) analysis revealed albumin-cytologic dissociation. The diagnosis of GBS was made based on clinical presentation and neurophysiological studies due to COVID-19. He was commenced on intravenous immunoglobulin, and improvement in his condition was observed. He was discharged to a rehabilitation center for regular physical therapy.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), generally presents as a respiratory infection. The severity of symptoms may vary from a common cold-like illness to severe lung infection leading to acute respiratory distress syndrome (ARDS), which is highly fatal. The infection generally presents with typical symptoms, such as fever, dyspnea, and cough, although some patients may be asymptomatic [1] [2] . Complications of severe infection, including septic shock, embolism, and multi-organ failure, have been reported in old age and patients with comorbidities. As the number of affected patients has grown, reports of neurological manifestations are increasing, which include altered mental status, Guillain-Barre syndrome (GBS), encephalopathy, psychosis, neurocognitive (dementia-like) syndrome, ischemic strokes, intracerebral hemorrhage, cerebral nervous system (CNS) vasculitis, and other cerebrovascular accidents. The literature has also underlined a correlation between GBS and a previous COVID-19 infection [3] . That correlation can either be considered a direct effect of the virus on the nervous system, para-infectious complication, or post-infectious immune-mediated response. Here, we describe a patient with an acute motor and sensory axonal neuropathy (AMSAN) variant of GBS following COVID-19.

A 45-year-old male with a past medical history of hypothyroidism was brought to the emergency department with sudden-onset, progressive, symmetric ascending weakness followed by worsening weakness and quadriplegia the night before admission. He had a history of cough, fever, and intermittent dyspnea one week before the onset of neurological manifestations. He had no history of fall, travel, or trauma. He had no bowel or urinary incontinence. On examination, he had a temperature of 99 o F, blood pressure of 125/85 mmHg, heart rate of 85 beats per minute, respiratory rate of 21 per minute, and oxygen saturation of 96% at room air. He was well-oriented in time, place, and person. After consulting with an infectious disease specialist, he underwent the testing of COVID-19. His reverse transcriptase-polymerase chain reaction (RT-PCR) came positive, and he was started on remdesivir and azithromycin. He had bilateral facial paresis with no signs of meningeal irritation or upper motor neuron lesion. Neurological examination revealed decreased muscle strength in all the limbs with a Medical Research Council (MRC) score of 2/5 in the proximal and 4/5 in the distal part of the upper limbs, and 1/5 in the distal and 2/5 in the proximal parts of the lower limbs. The patient had areflexia in lower limbs and hyporeflexia in upper limbs with no evidence of ataxia. He also complained of numbness and tingling over the lower extremities. On examination, hypoesthesia to fine touch and vibration distal to calf was noted. His initial blood investigations are shown in Table 1 . The cardiovascular and respiratory system review was normal. Cerebrospinal fluid (CSF) analysis on his second day of admission revealed albumin-cytologic disassociation (protein > 1.27 mg/L), with normal cell count and absence of oligoclonal bands. Magnetic resonance imaging (MRI) of the spine was unremarkable, with old age changes ( Figure 1 ). A diagnosis of GBS due to COVID-19 was made, and the findings were consistent with the AMASN variant of GBS. He was started on 0.40 g/kg per day intravenous immunoglobulin (IVIG) for five days in addition to drugs initiated for COVID-19 (remdesivir, azithromycin). His respiratory status was monitored periodically, along with the vitals. The patient's condition improved significantly on the following day, and he started regaining his muscle strength back. Power of the muscles and limb sensation improved significantly. He was discharged to a rehabilitation center for regular physical therapy.

SARS-CoV-2 is one of the seven types of coronaviruses that cause severe lung infection such as middle east respiratory syndrome (MERS) and SARS. Along with various common symptoms like fever, cough, dyspnea, body aches, and nausea, manifestations like pneumonia, liver diseases, respiratory failure, cardiac issues, stroke, and other neurological complications have been reported. One proposed mechanism of action is that SARS-CoV-2 distinguishes the angiotensin-converting enzyme 2 (ACE2) receptors while accessing the host cell receptor. High expression of the ACE2 receptors has been observed in the lung, gastrointestinal tract, cardiomyocytes, urothelial cells, and proximal tubular cells, affecting these systems. The neurons and glial cells of the nervous system also have an expression of ACE2 receptors, making the brain a potential target of SARS-CoV-2 presenting in the form of stroke, encephalopathies, vasculitis, and GBS [4] .

GBS is an immune-mediated disorder related to the peripheral nervous system. Progressive ascending weakness of the limbs and reduction in or loss of reflexes is the typical GBS presentation. On CSF analysis in this disease, the protein concentrations increase; however, the white cell count remains normal. A viral or bacterial infection is usually a causative agent of GBS. The immune system is triggered in response to the antigen. The nerve roots and peripheral nerves are inflamed and injured due to the structural similarity of this antigen to axons and myelin sheath. The symptoms peak within four weeks and warrant careful patient monitoring because 20% to 30% of them will require mechanical ventilation [5] .

GBS is usually seen after infection by campylobacter jejune, cytomegalovirus, Zika virus, and the Epstein-Barr virus. The increasing evidence of GBS after a preceding COVID-19 attack seems another addition to the list and raises concerns about the neurological and immune-mediated complications of COVID-19. To our knowledge, 29 articles reported 33 cases of GBS associated with SARS COV-2 in addition to our reported case [6] . AMSAN is an uncommon variant of GBS reported in COVID-19 infection, and we have underlined cases of AMSAN variant of GBS in COVID-19 disease so far ( Table 3) . Many theories explain the mechanism of neurological manifestations of COVID-19. SARS-COV-2 receptors are expressed in the nervous system, making it a new neuropathogenic, and can also explain the symptoms of headache, weakness, neuropathies, altered sensorium, and stroke in patients of COVID-19 [11] . Annexation through the cribriform plate and olfactory bulb and dissemination through the trans-synaptic transfer are some of the other proposed mechanisms [12] . The medullary cardiorespiratory center invasion by SARS-CoV-2 is considered a factor for refractory respiratory failure observed in critical patients. However, the CSF findings in our case and multiple other cases showed normal white blood cell (WBC) count indicating the role of immune-mediated molecular mimicry in the causation of GBS, which is reported as a rare cause of GBS in COVID-19 patients.

Our case presented with progressive ascending paresis culminating in quadriplegia, areflexia, bilateral facial paresis, and sensory losses one week after having symptoms of fever, cough, and intermittent dyspnea. On admission, the patient was tested for COVID-19, and his RT-PCR came positive. The detailed neurological examination, electrophysiological studies, CSF, and MRI confirmed the diagnosis of GBS of the AMSAN variant. A course of IVIGs was given for five days, and significant improvement was seen.

relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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A similar pattern of presentation of GBS following the respiratory symptoms of COVID-19 in all the cases suggests it to be one of the complications of COVID-19. Therefore, a physician should keep this complication in mind while treating COVID-19 patients. There should be at least one follow-up visit of all the discharged COVID-19 patients. Keeping in view the course of the presentation of GBS, IVIGs should be started to prevent grave complications like respiratory paralysis, sepsis, pulmonary embolism, and cardiac arrest. However, whether GBS is caused by an immune response due to molecular mimicry or by direct neurological invasion in COVID-19 is yet to be confirmed and demands further clinical studies.

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial