key: cord-0815024-plp5sxyl authors: Wang, Guan; Jin, Xian title: The progress of 2019 novel coronavirus event in China date: 2020-02-26 journal: J Med Virol DOI: 10.1002/jmv.25705 sha: d7830019ed9a5b013efb4fcd02ea7bc0bfd06807 doc_id: 815024 cord_uid: plp5sxyl It has been more than one month since the first 2019-nCov infected person was diagnosed. However, the number of cumulative cases is keeping upward, including the severe cases and death cases. It has been proved that droplets transmission is the major route for 2019-nCov infection, and interpersonal contact could also cause the disease. Due to the fast-growing of Wuhan pneumonia and relative low cure rate, Chinese government is facing great challenges, and has taken emergency measures on disease prevention and clinical treatment, including population mobility control, building five or more hospitals for Wuhan pneumonia treatment, such as "Huo Shen Shan" hospital as well as developing a specific vaccine. In the meanwhile, the government shared the updated Genome Sequence of 2019-nCoV to the public, and scientists from China and oversea are working tightly and efficiently on public health emergency. This article is protected by copyright. All rights reserved. It has been more than 1 month since the first 2019-nCoV infected person was diagnosed. So far, 42 638 people have been diagnosed as 2019-nCoV pneumonia, which also known as Wuhan pneumonia, among them, 7333 are severe cases, 1016 patients died, and only 3996 patients have been cured in the mainland of China (Hong Kong, Macao, and Taiwan were excluded). 1 All 31 provincial-level regions and the Xinjiang Production Corps have the confirmed cases. 1 Hubei province, where believed to be the origin of Wuhan pneumonia outbreak, suffers the most, with 31 728 confirmed cases and 974 death cases. 2 The trend of cumulative cases is soaring, including 24 other countries outside of China had confirmed cases. With a remarkable notice that the total number of cases has far exceeded the number during severe acute respiratory syndrome (SARS) period. The first case of 2019-nCoV pneumonia was linked to wild animal trading in the Huanan seafood market in the city of Wuhan, the capital of Hubei province. 3 Zhou et al 4 found the initial source of 2019-nCoV probably originated from the Chinese horseshoe bat since the novel coronavirus was 96% identical to a bat coronavirus at a whole genome level. This coronavirus, which has not been identified in humans previously, had been detected from patients in Coronaviruses are a huge family of viruses, of which severe acute respiratory syndrome coronavirus (SARS-nCoV) and Middle East respiratory syndrome coronavirus (MERS-nCoV), and so on have already known by humans. 8 The 2019-nCoV has an incubation period of 3 to 7 days in general, with a maximum of 14 days. 9 The most common symptoms at the onset of illness are fever, cough, and myalgia or fatigue. 9,10 While a few patients might have stuffiness, pharyngalgia, or diarrhea. 9 By far, the main sources of infection are 2019-nCoV infected humans, however, the asymptomatic infection might also be a source of infection. 9 These patients are not easy to be detected among the population when initially infected but might have headache, fever, dyspnea, fatigue, and so on later. 11 This type of coronavirus has been proved could spread from person to person through the respiratory tract and contact transmission. 9 be similar of SARS. 14 Mild and occult cases could be the major concerns for disease prevention. 15, 16 The World Health Organization (WHO) recommends wearing a medical mask when leaving homes 17 and ethanol and the high temperature had been proved could prevent disease occurrence. 9 The event has been determined as a Public Health Emergency of International Concern by WHO. 18 Humans are generally susceptible to coronavirus. 9 The youngest infected patient is only 1 month after birth. 19 Death cases were mostly found in the elderly and who already have chronic conditions. 10, 20 The confirmed case is defined as either positive of novel coronavirus nucleic acid by real-time fluorescent reverse transcription-polymerase chain reaction detection of respiratory or blood specimens or highly homologous to any known novel coronaviruses through virus gene sequencing of respiratory or blood specimens. Only when body temperature returns to normal for more than 3 days, respiratory symptoms significantly improved and two consecutive tests negative of the nucleic acid of respiratory pathogens, with at least 1 day on sampling interval, people could be allowed to discharge from hospital 9 (Figure 1 It has turned out to be urgent for epidemiologists, virologists, biologists, clinical doctors, and pharmaceutical researchers working together to battle against coronavirus outbreak. Human beings should engrave this zoonotic disease in mind for better dealing with "One-Human-Environmental-Animal-Health." 28 We believe this novel coronavirus could be wiped out under the joint efforts of scientists around the world soon. The authors express their deep thanks to the medical staff who are fighting in the front line. The authors appreciate their contributions very much. They also thank all the scientists and international cooperative organizations for supporting their country. The comparison between 2019-nCoV and severe acute respiratory syndrome event development The authors declare that there are no conflict of interests. http://orcid.org/0000-0001-6238-8002 Xian Jin http://orcid.org/0000-0002-5819-9935 National Health Commission of the People's Republic of China. Prevention and control of novel coronavirus infected pneumonia Health Commission of Hubei Province China coronavirus: what do we know so far? 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Health topics: Coronavirus detail/30-01-2020-statement-on-the-second-meeting-ofthe-international-health-regulations-(2005)-emergency-committeeregarding-the-outbreak-of-novel-coronavirus-(2019-ncov) A neonatal has been confirmed with 2019-nCoV pneumonia 30 hours after birth in Wuhan Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan China's response to a novel coronavirus stands in a stark contrast to the 2002 SARS outbreak response The Central Government of the People's Republic of China The national health commission sent medical staffs to support Wuhan city Chinese Center for Disease Control and Prevention At least six research teams around the world are racing against time The continuing 2019-nCoV epidemic treat of novel coronaviruses to global health-the latest 2019 novel coronavirus outbreak in Wuhan, China The progress of 2019 novel coronavirus event in China