key: cord-0812214-tc7cl4hn
authors: Purayil, Nishan; Sirajudeen, Jaseem; VA, Naushad; Mathew, Joe
title: COVID-19 Presenting as Acute Abdominal Pain: A Case Report
date: 2020-08-11
journal: Cureus
DOI: 10.7759/cureus.9659
sha: a2febeb968c3ffdd41029305c957aa38f14ca74e
doc_id: 812214
cord_uid: tc7cl4hn

As the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues across the globe, more details about the disease manifestations and clinical course have been emerging. The main clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic is respiratory symptoms. Along with this, the involvement of the gastrointestinal system and associated symptoms have also been reported. Here we present a case of a 58-year-old patient who presented with acute abdominal pain and was diagnosed with acute pancreatitis. He did not have any respiratory symptoms, but had radiological evidence of lung involvement and was diagnosed to be positive for COVID-19.

The ongoing pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has so far caused more than 500,000 deaths worldwide [1] . The most common presentation of patients with coronavirus disease-19 (COVID-19) is respiratory symptoms like cough and shortness of breath, however, gastrointestinal symptoms like abdominal pain, diarrhea, and vomiting are also reported. The detection of viral ribonucleic acid (RNA), in fecal specimens in patients with negative respiratory swab results, suggests a possibility of feco-oral transmission [2] .

Acute pancreatitis is one of the causes of acute abdominal pain in patients presenting to the emergency department. The development of acute pancreatitis is multifactorial and at times, the exact etiology cannot be identified. The most common cause is gallstones and alcohol abuse, but viral-induced acute pancreatitis has also been described [3] . This case report describes a patient with no precipitating factors presenting with abdominal pain to the emergency department; the patient was found to have pancreatitis and was screened positive for COVID-19.

A 58-year-old male patient presented with fever and vomiting for three days. This was associated with epigastric pain. No diarrhea. No respiratory symptoms. No urinary complaints. He was not on any regular medication. The examination was unremarkable except for mild epigastric tenderness. He was evaluated; his blood counts and liver function tests were normal ( Table 1) . His lipase was >600 U/L and amylase was 249 U/L. The chest X-ray revealed bilateral infiltrates ( Figure 1 ). In view of the chest X-ray detecting COVID-19, polymerase chain reaction (PCR) screening was done which turned out to be positive. The patient was started on 

The diagnostic criteria for acute pancreatitis requires the presence of two out of the following three criteria: 1) abdominal pain; 2) elevated amylase or lipase (more than three times the upper limit); 3) characteristic finding on imaging studies [4] . Studies have reported viral infection as one of the causes of acute pancreatitis. Infections like mumps, measles, coxsackie, Epstein-Barr virus, and hepatitis-A virus are commonly associated with pancreatitis [5] . It is reported that coronavirus infects human and animal species producing a myriad of symptoms [6, 7] . A report from China described the presence of acute pancreatic injury in about 17% of cases diagnosed to have COVID-19. The high affinity of SARS-CoV-2 to the angiotensin-converting enzyme-2 (ACE-2) is explained in the pathogenesis of COVID-19 [8] . The presence of ACE-2 receptors in pancreatic cells is being attributed to pancreatitis in patients with COVID-19. However, in a series of 71 cases, McNabb-Baltar et al. reported patients having elevated serum amylase levels with no other features of pancreatitis [9] .

Acute pancreatitis in patients with COVID-19 could be due to the direct cytotropic effect of the virus or due to the sequel of the immune response of the body. Szatmary et al. observed that the clinical course of pancreatitis in patients with COVID-19 is much more benign than expected; they also postulated pancreatico-duodenal inflammation with steatosis as a possible etiology [10] . In another study from Northern California, Gubatan et al. explored the possibility of patients with a past history of pancreatitis being more susceptible to COVID-19, however, the results were inconclusive [11] .

The patient developed symptoms like diarrhea and vomiting during the stay in hospital which can be due to the COVID-19 infection or can be due to the medications.

A wide spectrum of presentation and system involvement makes screening for COVID-19 important in patients presenting to the emergency department. No obvious cause for pancreatitis could be identified in this patient. Early identification and appropriate treatment is vital for good prognosis. Atypical presentation and multisystem involvement is a real challenge for frontline clinicians managing the pandemic.

Human subjects: Consent was obtained by all participants in this study.

In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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Pancreatitis and cholecystitis in primary acute symptomatic Epstein-Barr virus infection -systematic review of the literature

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