key: cord-0812019-vpti8kq0
authors: Janssen, Olivia; Thompson, Michael; Milburn, Sarah; Green, Robert; Wagner, Brian; Bianco, Angela; Stroustrup, Annemarie
title: The Impact of Perinatal SARS-CoV2 Infection During the Peripartum Period
date: 2020-10-20
journal: Am J Obstet Gynecol MFM
DOI: 10.1016/j.ajogmf.2020.100267
sha: 456778bb00678424707478be2f314311b817cd11
doc_id: 812019
cord_uid: vpti8kq0

• What is the impact of perinatal SARS-CoV2 infection on the incidence of preterm birth and stillbirth? • Is the rate of SARS-CoV2 infection predictable based on prevalence of significant disease in the community? • SARS-CoV2 infection did not increase the incidence of preterm birth or stillbirth. • The rate of SARS-CoV2 infection in women admitted to the delivery service tracked as 0.26% +/- 0.002% of total COVID-19 hospitalizations in our health system. • SARS-CoV2 infection in the labor and delivery population is predictable, and did significantly not increase rates of preterm birth or stillbirth in our health system.

Introduction: 10 Our large integrated health system in New York City implemented universal screening for infection 11 with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the virus causing pandemic 12 coronavirus disease in 2019 and 2020, of all women admitted to the labor service on 13 March 25, 2020. We also implemented universal screening of all neonates born to SARS-CoV2 14 positive mothers. Here we report perinatal SARS-CoV2 infection outcomes in our population during 15 the complete period of peak COVID-19 incidence and inpatient volume in the New York City area, The objective of this study was to assess the impact of SARS-CoV2 on the delivery and postpartum 23 services in a single health system in New York City during the period of peak COVID-19. Specifically, 24 we were interested in the clinical impact of SARS-CoV2 infection on the adverse pregnancy 25 outcomes of stillbirth and preterm birth during the period of peak pandemic. We were also interested 26 in the volume of SARS-CoV2 positive patients presenting to our labor floors as compared to COVID-27 19 admissions to other hospital services as we prepare for a possible "second wave" of the pandemic 28 this fall. Our goal with this study was to provide data necessary for such service preparedness. Methods: 32 We retrospectively identified women testing positive on a single admission polymerase chain reaction 33 test for SARS-CoV2 during the period of interest by automated query of the electronic medical record. 34 We then abstracted the maternal and infant medical records for relevant demographic and clinical 35 data, with particular attention to the adverse outcomes of interest intrauterine fetal demise (IUFD) ≥ 36 22 weeks gestation and preterm birth prior to 37 weeks gestation. As our study sample was drawn 37 from available clinical data, we also conducted power calculations to determine the sample size that 

Universal screening for SARS-CoV-2 in women admitted for 136 delivery

Prevalence of SARS-CoV-2 among patients admitted for 138 childbirth in southern connecticut

Characteristics and outcomes of 241 births to women with severe 140 acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at five New York City medical centers

Change in the incidence of 143 stillbirth and preterm delivery during the COVID-19 Pandemic

Births: Final Data

Vertical transmission risk of SARS-CoV-2 infection in the third 147 trimester: A systematic scoping review

the impact of perinatal SARS-CoV2 infection on the incidence of preterm birth and stillbirth? • Is the rate of SARS-CoV2 infection predictable based on prevalence of significant disease in the community? • SARS-CoV2 infection

• The rate of SARS-CoV2 infection in women admitted to the delivery service tracked as 0

002% of total COVID-19 hospitalizations in our health system

CoV2 infection in the labor and delivery population is predictable, and did significantly not increase rates of preterm birth or stillbirth in our health system