key: cord-0811050-kaj5gsti authors: Nataf, Serge title: An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID‐19 date: 2020-04-08 journal: J Med Virol DOI: 10.1002/jmv.25826 sha: 36f889c2b89bc5286f597f6639940cd2642661e8 doc_id: 811050 cord_uid: kaj5gsti I have read with great interest the paper by Yan Chao Lee et al. entitled "The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients"1. I would like here to provide arguments indicating that an alteration of the dopamine synthetic pathways is possibly involved in the pathophysiology of COVID-19. This article is protected by copyright. All rights reserved. An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID-19 To the Editor, I have read with great interest the paper by Li et al 1 The author declares that there is no conflict of interest. Serge Nataf 1,2,3 1 The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients Mining for coexpression across hundreds of datasets using novel rank aggregation and visualization methods The differential effect of angiotensin II and angiotensin 1-7 on norepinephrine, epinephrine, and dopamine concentrations in rat hypothalamus: the involvement of angiotensin receptors Kidney dopamine D1-like receptors and angiotensin 1-7 interaction inhibits renal Na+ transporters A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Depletion of angiotensinconverting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response Peripheral dopamine controlled by gut microbes inhibits invariant natural killer T cell-mediated hepatitis Frontline science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin-induced ALI Age-related dopaminergic innervation augments T helper 2-type allergic inflammation in the postnatal lung Emerging role of l-dopa decarboxylase in flaviviridae virus infections