key: cord-0810320-mnq8gq7b
authors: Ding, Yan-Zhi; Wang, Miao; Xia, Jun-Xia; Wang, Hai-Yan
title: Analysis of the sampling results in both an asymptomatic pregnant female with novel coronavirus pneumonia infection and the neonate
date: 2021-07-24
journal: Asian J Surg
DOI: 10.1016/j.asjsur.2021.06.047
sha: ba06793245f02a33db8da615851cadefba12217f
doc_id: 810320
cord_uid: mnq8gq7b

nan

Since its initial outbreak, novel coronavirus pneumonia(COVID-19) has spread across the world. As a population, pregnant females are in a special immune state during pregnancy. The maternal immune system protects the fetus from rejection by the mother through a complex set of immune responses and a series of changes.

Therefore, these women are susceptible to the novel coronavirus [1, 2] .

The patient is a 27-year-old female who tested positive for the novel coronavirus at a gestational age of 32 +6 weeks, using nucleic acid detection. Owing to the lack of symptoms, such as cough, expectoration and fever, and given her positive test for the novel coronavirus, the patient was considered to have an asymptomatic infection. At a gestational age of 40 +5 weeks, the patient was admitted to our hospital, owing to threatened labor, and gave birth naturally. She delivered a live baby. Sampling analysis was conducted on the mother using a nasal swab, throat swabs, placental lobules, amniotic fluid, and the umbilical cord, and also from the cord blood in the neonate. Because the patient had been infected with the novel coronavirus, the placenta was sent for pathology. The vaginal secretions, umbilical cord blood, peripheral blood, anal swab, placental lobules, and fetal membranes were tested using the nucleic acid detection test for the novel coronavirus and antibodies. The neonatal peripheral blood, anal swab, nasal swab, and throat swab were tested in the same way, and so was the breast milk (Table 1) It had no significance for the current COVID-19 infection [3] .

The neonatal nucleic acid results were all negative, and the blood antibodies were all positive. This was considered to be the protective antibodies from the maternal blood entering the fetal blood through the placental barrier after the recovery from COVID-19, rather than the infant's own antibodies caused by infection. The question of whether the fetus healed spontaneously after the intrauterine infection can only be answered by examining more cases during pregnancy. In short, there was no evidence that there existed mother-to-child vertical transmission in the present case [4, 5] .

Currently, the results are still inconclusive relating to whether mother-to-child 

Pregnancy, Viral Infection, and COVID-19

Coronavirus disease 2019 (COVID-19) pandemic and pregnancy

Pregnancy with new coronavirus infection:clinical characteristics and placental pathological analysis of three cases

Vertical Transmission of SARS-CoV-2 from an Asymptomatic Pregnant Woman in India

COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission