key: cord-0807073-vchnxw27
authors: Takita, M.; Matsumura, T.; Yamamoto, K.; Yamashita, E.; Hosoda, K.; Hamaki, T.; Kusumi, E.
title: Preliminary Results of Seroprevalence of SARS-CoV-2 at Community Clinics in Tokyo
date: 2020-05-05
journal: nan
DOI: 10.1101/2020.04.29.20085449
sha: 9859eb2f0753632a67812dfb06604f16e6bd6367
doc_id: 807073
cord_uid: vchnxw27

Serological evaluation with SARS-CoV-2 specific IgG antibody will be an alternative way to know the pandemic of novel coronavirus disease (COVID-19) if the capacity for diagnostic PCR test is limited. The point-of-care test to detect SARS-CoV-2 specific IgG antibody in peripheral blood (n =202) was performed in two community clinics in Tokyo, Japan. The overall positive rate of SRAS-CoV-2 IgG antibody was 5.9% (95% confidence interval[CI]: 3.1-10.1). Higher rate was observed for healthcare workers (n =55, 9.1 [3.0-20.0]). The limitation on antibody tests includes low sensitivity and potent cross-reactivity with the previous coronavirus. Robust healthcare policy to efficiently monitor COVID-19 spread is warranted in Tokyo.

Serological evaluation with SARS-CoV-2 specific IgG antibody will be an alternative way to know the pandemic of novel coronavirus disease if the capacity for diagnostic PCR test is limited. The point-of-care test to detect SARS-CoV-2 specific IgG antibody in peripheral blood (n =202) was performed in two community clinics in Tokyo, Japan. The overall positive rate of SRAS-CoV-2 IgG antibody was 5.9% (95% confidence interval[CI]: 3.1-10.1).

Higher rate was observed for healthcare workers (n =55, 9.1 [3.0-20.0]). The limitation on antibody tests includes low sensitivity and potent cross-reactivity with the previous coronavirus.

Robust healthcare policy to efficiently monitor COVID-19 spread is warranted in Tokyo.

. CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review)

The copyright holder for this preprint this version posted May 5, 2020. 

Delay in the expansion of the capacity for diagnostic PCR test to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Japan has made difficulties in evaluating the pandemic of novel coronavirus disease (COVID-19), in turn, planning appropriate public measures. 1 Serological evaluation with SARS-CoV-2 specific IgG antibody will be an alternative way to know how many people have been infected in the individual region. 2 The State of New York recently released the preliminary results of antibody tests showing that the SARS-CoV-2 specific IgG antibody was detected in approximately 15% of the citizens. 3 Of note, the WHO made a caution on the concept of Immunity Passport. 4 We here report our preliminary results of the SARS-CoV-2 specific IgG antibody measured by the point-of-care immunodiagnostic test (SARS-CoV-2 Antibody Testing Kit IgG RF-NC002, Kurabo Industries Ltd, Osaka, Japan) in the two community clinics located in the major railway stations in Tokyo (Navitas Clinic Shinjuku at Shinjuku Station and Navitas Clinic Tachikawa at Tachikawa Sta.). The Institutional Review Board of Navitas Clinic approved the study (Approval Number: NC2020-01). Asymptomatic subjects have been recruited by web posting of our clinic, and written consent was obtained prior to the test.

A total of 202 participants, including 55 healthcare workers (physicians, nurses, pharmacists, and laboratory technicians), participated in the study between April 21 and 28, 2020 (   Table) . A significant issue of pandemic COVID-19 is how we can identify and manage asymptomatically infected people, who may cause a chain of epidemic contagion and nosocomial infection in medical institutions, along with intensive medical care for severely symptomatic patients. 5 The limitation on antibody tests includes low sensitivity and potent cross-reactivity with the previous coronavirus. Our results, however, suggest a higher population infected with COVID-19 in metropolitan Tokyo than the national survey daily . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted May 5, 2020. . https://doi.org/10.1101/2020.04.29.20085449 doi: medRxiv preprint updated. 6 Robust healthcare policy to efficiently monitor COVID-19 spread is warranted in Tokyo.

. CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted May 5, 2020. 

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The copyright holder for this preprint this version posted May 5, 2020. . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

The copyright holder for this preprint this version posted May 5, 2020. . https://doi.org/10.1101/2020.04.29.20085449 doi: medRxiv preprint