key: cord-0806848-pbey4xpw authors: Licinio, Julio; Wong, Ma-Li title: Molecular Psychiatry, August 2020: new impact factor, and highlights of recent advances in psychiatry, including an overview of the brain’s response to stress during infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-07-28 journal: Mol Psychiatry DOI: 10.1038/s41380-020-0845-y sha: 4ac9c91b770df6fd4501a5ec94ab55f4a12237f1 doc_id: 806848 cord_uid: pbey4xpw nan We are delighted that the 2019 Impact Factor (IF) figures have recently been released by the Journal Citation Reports® Science Edition (Clarivate Analytics, 2020). As you know, the IF is calculated as total citations in 2019 of all papers published by a journal in 2017 + 2018 divided by the total numbers of full articles published in 2017 + 2018. I am delighted that the 2019 Impact Factor for Molecular Psychiatry is now 12.384 (an increase from 11.973 in the previous year). What is particularly remarkable is that we have achieved that while simultaneously increasing the number of outstanding work that we publish. Molecular Psychiatry's 2019 Journal Citation Reports ranking is as follows: 6th of 155 in Psychiatry, 10th of 271 in Neuroscience, and 11th of 297 in Biochemistry & Molecular Biology. We would like to sincerely thank all of you, authors, readers, and editorial board members, for your support of Molecular Psychiatry over the years, which has been essential for the journal to achieve its high level of continued success. This year we published four special issues, one on schizophrenia [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] , one on stress and behavior [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] , and two on depression, in June [39] [40] [41] [42] [43] [44] [45] [46] [47] [48] [49] [50] [51] [52] [53] [54] [55] and July . We now go back to our regular publishing schedule, highlighting in this issue incredible progress in several different areas of psychiatry. This editorial will highlight some of that progress. This exciting issue starts with a guest editorial by Steenblock et al., on the impact of SARS-CoV-2 infection and the neuroendocrine stress axis [77] . We then have two interesting Perspectives, one by the Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA), in which they examine an accelerated longitudinal cohort of children and adolescents in India [78] , and the other by Thapar & Riglin commenting on the importance of a developmental perspective in Psychiatry, and answering the essential question: what do recent geneticepidemiological findings show? [79] These exciting Perspectives are followed by three important Reviews: by Prieto et al. on post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction; by Rogdaki et al., a meta-analysis of the magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome [80] , and by Smigielski et al., a systematic review of empirical human findings on the epigenetic mechanisms in schizophrenia and other psychotic disorders [81] . We have Immediate Communications as a unique manuscript type in Molecular Psychiatry. Those papers are rapidly reviewed, and accepted only if the reviews are particularly favorable. They are then prioritized for publication. We have three Immediate Communications in this issue. Dempster et al. present a 7-T magnetic resonance spectroscopic study of glutathione and glutamate showing early treatment response in first-episode psychosis [82] ; Niculescu et al. present intriguing work on blood biomarkers for memory that can be targeted toward early detection of risk for Alzheimer's disease (AD), pharmacogenomics, and repurposed drugs [83] , and Polimanti et al. leverage genome-wide data to investigate differences between opioid use versus opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium [84] . Regular articles in this issue start with the paper that is the topic of our Image Section, in which we highlight striking figures that illustrate important new discoveries. In that article, Du et al. show that cocaine-induced ischemia in the prefrontal cortex is associated with escalation of cocaine intake in rodents [85] . In other original research articles, we present key new advances across multiple fields. Kendler et al. show that the risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from highdensity pedigrees is moderated by personal, family, and community factors [86] . Harrison et al. present a systematic review and meta-analysis of the neuropathology of bipolar disorder [87] . Brikell et al. examine the contribution of common genetic risk variants for attention-deficit/hyperactivity disorder (ADHD) to a general factor of childhood psychopathology. Their results suggest that common genetic risk variants associated with ADHD, and captured by polygenic risk scores (PRS), also influence a general genetic liability towards broad childhood psychopathology in the general population, in addition to a specific association with hyperactivity/impulsivity symptoms [88] . In our beautiful cover article, Sun et al. conducted largescale mapping of cortical alterations in 22q11.2 deletion syndrome demonstrating convergence with idiopathic psychosis and effects of deletion size [89] . They found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure and that psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. Our original research articles continue with other remarkable papers. Amal et al. provide evidence that mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function [90] . In a randomized clinical trial conducted in Japan, Yamasue et al. studied the effects of intranasal oxytocin on the core social symptoms of autism spectrum disorder (ADS) [91] . They did not find highly beneficial clinical outcomes other than on repetitive behavior and gaze fixation on socially relevant regions. There were no significant differences in the prevalence of adverse events between groups. Based on their findings, they cannot recommend continuous intranasal oxytocin treatment alone at the current dose and duration for treatment of the core social symptoms of high-functioning ASD in adult men, although this large-scale trial suggests oxytocin's possibility to treat ASD repetitive behavior. Bis et al. used whole-exome sequencing to identify novel rare and common AD-associated variants involved in immune response and transcriptional regulation [92] . In our last original article, Temido-Ferreira shows that age-related shift in long-term depression (LTD), is dependent on neuronal adenosine A2A receptors (A2AR) interplay with metabotropic glutamate receptor type 5 (mGluR5) and N-Methyl-daspartate (NMDA) receptors [93] . The authors suggest that this A2AR/mGluR5/NMDAR interaction might prove a suitable alternative for regulating aberrant mGluR5/ NMDAR signaling in AD without disrupting their constitutive activity. These superb articles across a variety of field of great importance to the broad field of molecular psychiatry demonstrate that Molecular Psychiatry, with a new IF of 12.384, is now the premier journal in our field that integrates clinical psychiatry with molecular neurobiology, genetics/genomics, imaging, and other state-of-the-art approaches that unravel the pathways and mechanisms underlying psychiatric disorders. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals Advances in schizophrenia research: first special issue, 2020 Machine learning-guided intervention trials to predict treatment response at an individual patient level: an important second step following randomized clinical trials The role of the retinoids in schizophrenia: genomic and clinical perspectives Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation Intracellular compartmentspecific proteasome dysfunction in postmortem cortex in schizophrenia subjects Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain NDUFV2 pseudogene (NDUFV2P1) contributes to mitochondrial complex I deficits in schizophrenia Missense variants in ATP1A3 and FXYD gene family are associated with childhoodonset schizophrenia Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19) Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank Baseline brain structural and functional predictors of clinical outcome in the early course of schizophrenia Glutathione and glutamate in schizophrenia: a 7T MRS study Prevention of schizophrenia deficits via noninvasive adolescent frontal cortex stimulation in rats Treatment response prediction and individualized identification of first-episode drug-naive schizophrenia using brain functional connectivity Advances in research on stress and behavior: special issue, 2020 Thyroid hormone overexposure decreases DNA methylation in germ cells of newborn male mice Thyroid hormone influences brain gene expression programs and behaviors in later generations by altering germ line epigenetic information Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs MiR-218: a molecular switch and potential biomarker of susceptibility to stress Correction: MicroRNA regulation of persistent stressenhanced memory MicroRNA regulation of persistent stress-enhanced memory Hippocampal micro-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval Protective effects of elevated anandamide on stress and fearrelated behaviors: translational evidence from humans and mice A POMCoriginated circuit regulates stress-induced hypophagia, depression, and anhedonia Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior Maternal Type-I interferon signaling adversely affects the microglia and the behavior of the offspring accompanied by increased sensitivity to stress The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitiveaffective and somatic symptoms Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study Colocalization of circDYM with miR-9 in microglia Advances in depression research: special issue, 2020, with three research articles by Paul Greengard Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressivelike behavior of treatment-resistant depressed rats Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects Effects of immunomodulatory drugs on depressive symptoms: a mega-analysis of randomized, placebocontrolled clinical trials in inflammatory disorders Systemic inflammation is associated with depressive symptoms differentially by sex and race: a longitudinal study of urban adults What does plasma CRP tell us about peripheral and central inflammation in depression? A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder A methylation study of long-term depression risk Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples Modelling the single most common SNP in OPRM1 (A118G) using human neurons generated from two sets of independently targeted isogenic stem cell lines Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons Advances in depression research: second special issue, 2020, with highlights on biological mechanisms, clinical features, co-morbidity, genetics, imaging, and treatment The role of the dentate gyrus in stress-related disorders AP-1 controls the p11-dependent antidepressant response Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank The symptom network structure of depressive symptoms in late-life: Results from a European population study Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies Discovery and replication of cerebral blood flow differences in major depressive disorder White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group Reward related ventral striatal activity and differential response to sertraline versus placebo in depressed individuals Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder Opioid system modulation with buprenorphine/ samidorphan combination for major depressive disorder: two randomized controlled studies Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatmentresistant depression (TRD) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis. Mol Psychiatry The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India. Mol Psychiatry The importance of a developmental perspective in Psychiatry: what do recent genetic-epidemiological findings show? Mol Psychiatry Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a metaanalysis. Mol Psychiatry Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings. Mol Psychiatry Early treatment response in first episode psychosis: a 7-T magnetic resonance spectroscopic study of glutathione and glutamate. Mol Psychiatry Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs Leveraging genome-wide data to investigate differences between opioid use vs Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees: its moderation by personal, family, and community factors The neuropathology of bipolar disorder: systematic review and meta-analysis. Mol Psychiatry The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: convergence with idiopathic psychosis and effects of deletion size Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial. Mol Psychiatry Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors