key: cord-0806434-6kn95ixl
authors: Ye, Sheng; Zhang, Yongjun; Zhao, Xiang; Yu, Zhen; Song, Yang; Tan, Zhangping; Tang, Yun; Chen, Shuang; Wang, Mingyue; Ling, Hua
title: Emerging Variants of B.1.617 Lineage Identified Among Returning Chinese Employees Working in India — Chongqing Municipality, China, April 2021
date: 2021-05-07
journal: China CDC Wkly
DOI: 10.46234/ccdcw2021.109
sha: 0200ea768cee607bfa953a4ddc312ed6165d63b8
doc_id: 806434
cord_uid: 6kn95ixl

nan

(GenBank Accession: NC_045512), also known as SARS-CoV-2, these isolates possessed 34-36 variation sites in nucleic acids, including 8-10 variations in the spike protein. Phylogenetic analysis of genome sequences indicated these isolates belonged to the Pangolin lineage B.1.617, an emerging variant in India first identified in October 2020 and has recently been designated as variants of interest (VOIs) by the World Health Organization (WHO) ( Figure 1 ) (1-2). Notably, 6 variation sites of amino acid residuals (T19R, L452R, T478K, D614G, P681R, and D950N), which were identical to those in Indian B. 

Weekly epidemiological update on COVID-19 -27

Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra

TJ138/Tianjin_strain EPI_ISL_420081|hCoV-19/Russia/StPetersburg-RII3997/2020|Europe/Russia|

The 3 Chongqing strains are indicated by red dots; the representative strains from B.1.617 lineage are highlighted with a yellow background; strains associated with specific outbreaks in China are indicated by blue squares; and the Wuhan reference strain is shaded in gray. The PANGOLIN lineages were marked and colored on the right. The tree was rooted using strain WH04 (EPI_ISL_406801) in accord with the root of PANGOLIN tree.