key: cord-0801735-r64ujhm5 authors: Sheen, Yi‐Jing; Huang, Chien‐Chung; Huang, Shih‐Che; Lin, Ching‐Heng; Lee, I‐Te; H‐H Sheu, Wayne title: Electronic dashboard‐based remote glycemic management program reduces length of stay and readmission rate among hospitalized adults date: 2021-02-20 journal: J Diabetes Investig DOI: 10.1111/jdi.13500 sha: 358741374aa76374444af9322b9d1f83028f71cd doc_id: 801735 cord_uid: r64ujhm5 AIMS/INTRODUCTION: Currently, the impact of hospital‐wide glycemic control interventions on length of hospital stay (LOS) and readmission rates are largely unknown. We investigated the impact of a 4‐year hospital‐wide remote glycemic management program on LOS and 30‐day readmission rates among hospitalized adults who received glucose monitoring. MATERIALS AND METHODS: In this retrospective study, hospitalized patients who received glucose monitoring were classified into groups 1 (high glucose variability), 2 (hypoglycemia), 3 (hyperglycemia) and 4 (relatively stable). The monthly percentage changes, and average monthly percentage changes of hyperglycemia, hypoglycemia and treat to target were determined using joinpoint regression analysis. RESULTS: A total of 106,528 hospitalized patients (mean age 60.9 ± 18.5 years, 57% men) were enrolled. We observed a significant reduction in the percentage of inpatients in poor glycemic control groups (groups 1, 2 and 3, all P < 0.001), and a reciprocal increase in the relatively stable group (group 4) from 2016 to 2019. We found a significant reduction in LOS by 11.4% (10.5–9.3 days, P = 0.002, after adjustment for age, sex, and admission department). The 30‐day readmission rate decreased from 29.9% to 29.3%, mainly among those in group 4 in 2019 (P < 0.001 after adjustment of sex, age, admission department and LOS). CONCLUSIONS: Improved glycemic control through a hospital‐wide electronic remote glycemic management system reduced LOS and 30‐day readmission rates. Findings observed in this study might be associated with the reduction in cost of avoidable hospitalizations. The prevalence of diabetes and its complications are still growing, and pose an enormous threat to public and global health 1,2 . Furthermore, diabetes is an important driver of direct and indirect costs and burdens, caused by frequent hospitalizations, disability and absence from work 1-4 . Previous studies showed that patients with diabetes not only have a higher risk of hospital admission, but also have longer length of stay (LOS) and more frequent hospital readmissions than those without diabetes 5, 6 . In addition, patients with diabetes had a significantly increased risk of in-hospital mortality 5 . Inpatients who experienced hyperglycemia and hypoglycemia events were also found to have higher readmission and mortality rates 7, 8 . The benefits of intensive glycemic control for inpatients remain controversial 9, 10 . An early study reported that inpatient glycemic control managed by an integrated team of healthcare professionals shortened LOS for patients with diabetes, albeit with a non-significant increase in hypoglycemia events 11 . Another retrospective observational study reported that LOS and 30-day readmission rates decreased in patients co-managed by a specialized diabetes team 12 . However, it is unclear whether a hospital-wide remote glycemic intervention system could influence hospital LOS and subsequent readmission. Our previous study showed that a hospital-wide inpatient remote glycemic management program, supported by a team led by endocrinologists, efficiently decreased hyperglycemia and hypoglycemia events in hospitalized adults from 2016 to 2018 13 . In the study presented here, the observation was extended to another year (2019), during which several intensified steps were implemented for the glycemic management program. We examined whether the beneficial effects of our hospital-wide glycemic management program could translate into shortened LOS and lower 30-day readmission rates among hospitalized adults. We retrospectively analyzed the effects of implementing a hospital-wide glycemic management program on the LOS and 30day readmission rates among hospitalized adults who received glucose monitoring. The glycemic management program was initiated in 2017 and fully implemented in 2018. In 2019, several intensified steps were introduced that included repeated reinforced education training programs for attending physicians, residents and nurse practitioners among all departments, and provided automatic real-time warning messages of hypoglycemia included checking all medication orders for hypoglycemic patients and informing the primary care team to stay alert for hypoglycemia-prone medications. We divided the observation period into pre-implementation (2016), development (2017), implementation (2018) and intensification (2019). All study participants were enrolled from Taichung Veterans General Hospital (TCVGH), a 1,500-bed public medical center in central Taiwan. We excluded patients from the pediatric and emergency departments. To minimize selection bias, we did not exclude specific medical condition, insurance situation and scheduled readmissions while analyzing the readmission rates. Details on the implementation of this program have been presented previously 13 . The study was approved by the institutional review board of TCVGH, and the requirement for informed consent (approval certificate number: CE20061A) was waived. Hospital-wide monitoring system and glycemic management program The glycemic management team was formed and led by endocrinologists. The inpatient glucose bedside point-of-care devices data management systems, in combination with the CONTOUR TM PLUS, BGMS blood glucose monitoring system (Ascensia Diabetes Care Holdings AG, Basel, Switzerland, through the acquisition of Bayer Diabetes Care by PHC Holdings), met the ISO 15197: 2013 and US Food and Drug Administration blood glucose meter accuracy standards [14] [15] [16] . Glucometer data were uploaded to the electronic medical record system directly and automatically through a wireless connection. We established an electronic dynamic glucose dashboard that monitored all hospitalized inpatient point-of-care and plasma glucose values. Information from the dashboard was automatically updated every night at 00.00 hours. Poor glycemic control included hyperglycemia, defined as two or more glucose values ≥300 mg/dL, and hypoglycemia, defined as a glucose level <70 mg/dL, during the previous 24 h. Inpatients were classified into four groups. Group 1 (high glucose variability) included those who had two hyperglycemia events plus at least one hypoglycemia event within 24 h during hospitalization. Group 2 (hypoglycemia) patients had at least one hypoglycemia event during hospitalization. Group 3 patients (hyperglycemia) had at least one hyperglycemia event during hospitalization. Group 4 patients (relatively stable) did not have any hyperglycemia or hypoglycemia episodes during hospitalization. The glycemic management program integrated the following: (i) an electronic glucose dashboard that analyzed and monitored all hospitalized inpatient glucose point-of-care glucose and plasma glucose data from the biochemistry laboratory (Figure S1 ). Both automatic and manual mode are available; information was automatically updated every night at 00.00 hours, and we can also update the real-time data by manual model; (ii) a glycemic management system that could send daily warning messages ( Figure S2 ); (iii) remote glycemic management recommendations ( Figure S2 ); and (iv) timely warnings and recommendations for the prevention of hypoglycemia (Figure S2) 13 . The automatic real-time warning messages included checking all medication orders for hypoglycemic patients and informing the primary care team to stay alert for hypoglycemia-prone medications. Virtual glycemic management recommendations summarized the suggestions of administration of glucose-lowering drugs, dose and administration method 13 . We informed the primary care team members that these recommendations were only a part of the clinical decision support system based on the patient's recent blood glucose status and clinical data without visiting patients. Their consideration of the patient's clinical status is extremely important. The formal endocrinology consultation services were available if required 13 . Characteristics of the inpatients are presented as descriptive statistics, and include sex, age, glucose monitoring during the admission period, LOS and 30-day readmission rate from 2016 to 2019. Continuous descriptive variables are presented as meansstandard deviations, glucose coefficient of variation (standard deviation/mean) data are listed as medians with interquartile ranges in parentheses, and categorical variables are presented as percentages. The proportion (%) of patients with poor glycemic control treated to target range were expressed as 'per day per 100 patients with glucose monitoring.' The joinpoints (years at which trends change significantly) and average monthly percentage changes and the corresponding 95% confidence intervals (CIs) were calculated using joinpoint regression analysis via Joinpoint Trend Analysis Software (version 4.8.0.1) from the Surveillance Research Program of the US National Cancer Institute [17] [18] [19] . The Cochran-Armitage trend test was used to estimate the linear association of LOS and readmission for the years of the study period. We adjusted for factors associated with 30-day readmissions, including sex, age, department of admission and LOS. Statistical significance was defined as P < 0.05. All statistical analyses were carried out with SAS software version 9.4 (SAS Institute Inc., Cary, NC, USA). We presented data on a total of 106,528 inpatients with a mean age of 60.9 years; the men enrolled in the study slightly outnumbered the women during the 4-year monitoring period ( Table 1) . Although the percentage of hospitalized adults requiring glucose monitoring increased by 24% from 2016 to 2019 (23,739 and 29,447 patients in 2016 and 2019, respectively), we found a significant reduction in the number of participants with poor glycemic control (group 1, 2 and 3, all P < 0.001) after implementation of the hospital-wide glucose management program. Our efforts also resulted in a significantly increased percentage of patients in group 4 (those with relatively stable glycemic levels) during the 4-year observation period (Table 1) . Figure 1 shows the trend in glycemic control from January 2016 to December 2019. Although the proportion of patients with poor glycemic control (including those with hypoglycemia and hyperglycemia) did not change during the pre-implementation period (2016), we found a significant and persistent lower rate of poor glycemic control over the following 3 years (2017-2019, P trend <0.001). Specifically, the mean proportion of patients with poor glycemic control decreased by 41% (from 10.2% to 6.0%), the rate of those with hyperglycemia decreased by 43% (from 6.1% to 3.5%) and the rate of those with hypoglycemia decreased by 50% (from 4.2% to 2.1%), all P < 0.001 ( Table 2 ). In addition, the rate of patients with glucose level ≥270 mg/dL decreased by 40% (from 9.6% to 5.8%, P < 0.001), and the rate of severe hypoglycemia (defined as a glucose level <50 mg/dL) decreased by 49% (from 1.06% to 0.54 %, P < 0.001; shown in Table 2 and Figure 1 ). The proportion of patients with glucose levels within the target range (110-180 mg/dL) increased significantly by 16% (25.7-29.8%) from 2016 to 2019 (Table 2) . We analyzed data of reaching the target range frequently used for continuous glucose monitoring study (70-180 mg/dL) shown in Table 2 and Figure 1 . The proportion of patients who adopted treat to target in range (70-180 mg/dL) increased by 15% (49.2-56.7%, P = 0.004) during the study period (Table 2; Figure 1 ). Significant improvement of glucose variability was also founded by the decrease of patients of group 1 and reduction of glucose coefficient of variation (shown in Table 1 ). Table 3 shows the estimated trends for the proportions of patients (per day per 100 patients with glucose monitoring) with hyperglycemia, hypoglycemia and treat to target, based on analysis of the joinpoint regression model. From 2016 to 2019, significant improvements of the average monthly percentage changes for hyperglycemia, hypoglycemia and treat to target were -0.2%, -0.2% and 0.1%, respectively (Table 3) . For inpatients with hyperglycemia, the monthly percentage changes increased significantly for trend 1, which was followed by a significant decrease in trends 2 and 3. For inpatients with hypoglycemia, we found significant decreases in both trend 2 and trend 3. Regarding the proportion of treat to target, significant increases were found for trend 2 and trend 3. Univariate regression for trend analysis was carried out, and the results were consistent with the joinpoint regression: significant improvements of glycemic control were found for trend 2 and trend 3 (footnote of Table 3 ). From 2016 to 2019, we observed an 11.4% reduction in the mean LOS from 10.5 to 9.3 days (P = 0.002) after adjusting for age, sex and admission department ( Figure 2 ). Patients in group 1 who experienced hyperglycemia and hypoglycemia over a 24-h period during their hospitalization had the longest average hospital LOS, whereas patients with relatively stable glycemic control (group 4) had the shortest mean LOS (Table S1) . The results of total and group-specific 30-day readmission rates are presented in Table 4 . The 30-day readmission rates of patients with glucose monitoring are higher than hospital-wide readmission rates (10.0-11.0%, unadjusted P trend = 0.084), and decreased from 2016 to 2019 (29.9-29.3%, P < 0.001 after adjustment for sex, age, admission department and LOS). However, none of the readmission rates reached statistical significance for groups 1, 2 and 3. For group 4, we did find that 30day readmission rates increased in 2017 and 2018, and decreased greatly in 2019, with a significant trend of reductions in 30-day readmission rates (Table 4 ). We recently reported on the successful experiences of a hospital-wide glycemic management program that reduced hyperglycemia and hypoglycemia in hospitalized adults 13 . This present study was an extension of our previous observations with addition of several intensified management measures. Our study showed further reductions in the number of inpatients with poor glycemic control (hyperglycemia and hypoglycemia), and more inpatients had glucose levels within the target ranges. Compared with other institution-wide inpatient glycemic management systems 20-23 , our program enrolled relatively more hospitalized adults, had a longer observation term (observed for 4 years), and ranked highly in improvements in glycemic control and maintenance. Interestingly, as compared with usual care (a referral-based consultation service), a recent study reported that proactive or early intervention by endocrinologists decreased the proportion of patients with hyperglycemia (>270 mg/dL) to 3.3% 24 , which was similar to our study. However, in that work, there was no significant reduction in the proportion of patients with hypoglycemia (<72 mg/dL), which is contrary to the present study, which had a 50% decrease in the prevalence of hypoglycemia (<70 mg/dL, from 4.2% to 2.1%). According to the results of joinpoint regression, we can find a steep improvement in hypoglycemia, hyperglycemia and treat to target during trend 2. Significant progress has been made in the 3rd to 6th months after implementation of the program, and with additional significant improvement throughout the following observation period of our study (trend 3). We analyzed the antidiabetes drugs used during hospital stay (Table S2 ). These drugs have good glucose-lowering efficacy and stable safety. The use of these newer antidiabetes drugs increased over the study period, especially sodium-glucose cotransporter 2 inhibitors. However, the use of glucagon-like peptide-1 receptor agonists or sodium-glucose cotransporter 2 inhibitors remained <5% throughout the observation periods. These new drugs used in hospitalized patients were limited due to the acute illness or stress conditions (poor appetite, renal function impairment, metabolic acidosis, preparation for operations), and considerations of the adverse effects. The use of antidiabetes drugs might not be the main cause of the improvements in glycemic control, LOS or readmission rate. Our findings are quite timely, as the world is grappling with a new pandemic of COVID-19 25, 26 . A reduction of the hospital-wide formal endocrinology consultation rate from 2016 to 2019 (from 1.32% to 1.20%, not shown in tables) was found according to our observation. We believe that the remote glycemic recommendations led by endocrinologists could help to improve inpatient glycemic control, and minimize the risk of exposure and subsequent nosocomial infections. Patients with diabetes are at a higher risk of prolonged LOS than those without diabetes 5, 6, 27, 28 . Several studies have shown a relationship between poor glycemic control and an increased LOS [29] [30] [31] , especially among those with associated comorbidities, such as stroke, hospitalization for bone marrow transplantation and heart failure [32] [33] [34] [35] . The association between hospital hyperglycemia and prolonged LOS was also observed among those without a previous history of diabetes (including undiagnosed diabetes and new-onset hyperglycemia during hospitalization) 35, 36 . Additionally, those with hypoglycemia were more likely to have prolonged LOS and poor disease outcomes. There was an increase of 0.75 days in LOS per each event of hypoglycemia during hospitalization 31 . A retrospective study also showed that patients with hypoglycemia are prone to increased LOS and a higher mortality rate 37, 38 . Recently, an introduction of inpatients' early glycemic intervention (an inpatient diabetes team electronically identified individuals with diabetes and aimed to provide bedside management within 24 h of admission) reduced the proportion of inpatients with hyperglycemia and hospital-acquired infection, but did not affect LOS, as compared with traditional glycemic intervention 24 . The present findings clearly show that the implementation of a hospitalwide glycemic management program not only improved glycemic control, but also significantly decreased LOS by 11.4% (from 10.5 to 9.3 days) during the 4-year observation period after adjustment for age, sex and admission department (P = 0.002). The underlying condition might be the main factor affecting the LOS. We analyzed the principal diagnosis during the four different periods (shown in Table S3 ) and established that the distribution of principal diagnoses was similar throughout the observation period. Furthermore, we did not adjust for the department of admission and diagnosis at the 39 . In addition, previous research found that inpatients with glycemic variability had a longer LOS and higher mortality 40 . The present study also found that patients who experienced high glucose variability (group 1) had the longest average hospital LOS, which is in line with the findings of a previous report 40 . The mean LOS in the present study ranged from 21.8 to 24.7 days, which was similar to the LOS in patients with diabetes and a history of amputation, reported as the complication of diabetes with the longest LOS in Taiwan 39 . According to the results of the present study, 30-day readmission rates for inpatients with glucose monitoring were higher than the rate for all hospitalized patients (10.0-11.0%), consistent with previous findings. Our study showed the benefits of a hospital-wide glycemic management program, which included a significant reduction in the 30-day readmission rate after adjusting for sex, age, admission department and LOS (29.9-29.3% from 2016 to 2019, P < 0.001). There was no policy related to admission or discharge in our hospital during the observation periods. Previous evidence shows that both patients with diagnosed and with newly onset diabetes have higher readmission rates 6, 28, 41 . An urban teaching hospital-based study reported that the 30-day readmission rates were higher in patients with diabetes than those without diabetes (15.3% vs 8.4%, respectively, P < 0.001) 28 . Another study reviewed 7,763 admissions at the University of Michigan Health System, and found that 30-day readmission rates for hospitalized patients with diabetes were up to 22.7% and were higher than the rate for all hospitalized patients (8.5-13.5%) 41 . It was also shown that patients who experienced hypoglycemia were at risk for readmission 7, 38 . Thus, although patients with either hyperglycemia or hypoglycemia were known to have higher risks of readmission, the benefits of intensive glycemic control on readmission rates remain largely unknown 9, 10 . The readmission rate of the present study is higher than in a previous review 41 , which might be related to the disease severity of our hospital (TCVGH is a major medical center of central Taiwan). Furthermore, to minimize selection bias, we did not exclude any specific medical condition or insurance situation. The exclusion criteria of previous studies for evaluation readmission rate varied, such as scheduled readmission for chemotherapy or operation, some excluded patients who were transferred to other hospitals on the day of discharge and patients who were discharged on the day of admission, some excluded underlying conditions, patients admitted with exceptionally long LOS or insurance situation, and so on. 6, 7, 12, 28, 38, 41, 42 We tried to avoid distortion of accounting information caused by human factors. Many factors were shown to influence readmission, including socioeconomic status, belonging to a racial or ethnic minority, comorbidity burden, public insurance availability, emergent or urgent admission, inherently complicated disease processes, patient characteristics and the diversity of patient conditions 6, 7, 42 . Only one recent study showed that 30-day readmission decreased significantly among patients co-managed by a specialized diabetes team (mean 30-day readmission decreased by 10.71%) 12 . Nevertheless, this will take time and considerable resources, and might be impractical due to the growing number of inpatients with glucose monitoring. Data from the present study showed that the reduction in 30-day readmissions is likely on account of patients in group 4 (which accounted for >80% of all discharges) having relatively stable glucose levels (5% reduction from 32.1% to 30.4%, adjusted P < 0.001). Given that the inherent conditions of this group were quite heterogenous, with various causes of hospitalization, we believe that they also benefited from our hospitalwide glycemic management program. During the observation period, a significant improvement of glucose variability analyzed by glucose coefficient of variation was found, mainly in group 4 ( Table 1) ; we can also find a significant improvement of treat to targets, and these improvements could affect the patients among group 4, the relatively stable group. The educational programs and warning messages Table S1 . P for trend: adjusted for sex, age and admission department. SD, standard deviation. were of tremendous value 13 . The recommendation by endocrinologists might also improve the ability of glycemic control 13, 23 . The ways to improve glycemic control and treat to target included better management of underlying conditions, and these improvements might lead to a consequent improvement of readmission rate. The main limitation of the present study was its retrospective and observational design. Although external validity might be lacking, the demographic characteristics of the patients in this study were similar to the nationwide population, based on the overall distribution of diabetes in Taiwan 4 . The hospital featured in this study is a major medical center of central Taiwan and a place that cares for the more severely ill patients. We analyzed the principal diagnosis; furthermore, we did not adjust for department of admission and diagnosis simultaneously, as diagnosis is strongly correlated to the department of admission. The raw data of all hospitalizations were not available (limited by the study population approved by the institutional review board), and we were not able to adjust for the confounders while analyzing the LOS and readmission of all hospitalized patients. This study aimed to observe the general effects of our institutional-wide glucose management program on the LOS and readmission rates of the entire inpatient population receiving glucose monitoring. However, the underlying condition might be the main factor affecting LOS and readmission. Therefore, further studies are warranted to validate the impact of glycemic management programs on disease-specific LOS, readmissions, mortality and health expenditures among hospitalized patients. We did not consider the responses of primary care teams to our recommendations. Finally, with different definitions of poor glycemic control and clinical conditions for the study inpatients, the present results cannot be compared with those of previous studies directly. The present findings show that the implementation of a hospital-wide glycemic management program not only further improves glycemic control, but also significantly reduces LOS and 30-day readmission rate among hospitalized adults. These improvements might alleviate many current health burdens. Further prospective studies are required to investigate the effects of glycemic management among inpatients, and how this affects healthcare quality measurements and disease outcomes. We express our deep gratitude to Chia-Hui Shen and Jun-Peng Chen for data collection and analysis. We also extend our thanks to the Biostatistics Task Force and Division of Clinical Information, Center of Quality Management of Taichung Veterans General Hospital, Taichung, for their help in offering us resources and analysis. This study was supported in part by the Taichung Veterans General Hospital, Taiwan (TCVGH-1090101C, and TCVGH-1090102D); from the Ministry of Science and Technology, Taiwan (MOST 107-2314-B-075A- Additional supporting information may be found online in the Supporting Information section at the end of the article. Figure S1 | A dynamic electronic blood glucose monitoring dashboard for hospitalized patients. Figure S2 | An electronic glycemic management system for hospitalized patients. Table S1 | Length of stay of hospitalized adults with glucose monitoring. International Diabetes Federation. 2019 Diabetes Atlas -9th Edition. www.diabetesatlas.org Economic costs of diabetes in the U.S Sheu WHH 2019 diabetes atlas: achievements and challenges in diabetes care in Taiwan Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan Does diabetes mellitus comorbidity affect in-hospital mortality and length of stay? Analysis of administrative data in an Italian academic hospital Correction to: Hospital readmission of patients with diabetes Risk factors for 30-day readmission following hypoglycemia-related emergency room and inpatient admissions Association of hypoglycemia with mortality for subjects hospitalized with pneumonia Intensive versus conventional glucose control in critically ill patients Intensive glucose control in the management of diabetes mellitus and inpatient hyperglycemia Effects of a subcutaneous insulin protocol, clinical education, and computerized order set on the quality of inpatient management of hyperglycemia: results of a clinical trial Retrospective study of inpatient diabetes management service, length of stay and 30-day readmission rate of patients with diabetes at a community hospital Implementation of an electronic dashboard with a remote management system to improve glycemic management among hospitalized adults Multiple hospitalizations for patients with diabetes Accuracy evaluation of CONTOUR((R))PLUS compared with four blood glucose monitoring systems Investigation of the accuracy of 18 marketed blood glucose monitors Clustering of trend data using joinpoint regression models Trends in prescriptions for sedative-hypnotics among Korean adults: a nationwide prescription database study for 2011-2015 ) from the Surveillance Research Program of the US National Cancer Institute Institutional blood glucose monitoring system for hospitalized patients: an integral component of the inpatient glucose control program Daily inpatient glycemic survey (DINGS): a process to remotely identify and assist in the management of hospitalized patients with diabetes and hyperglycemia Impact of an inpatient multidisciplinary glucose control management program Association between a virtual glucose management service and glycemic control in hospitalized adult patients: an observational study Early intervention for diabetes in medical and surgical inpatients decreases hyperglycemia and hospital-acquired infections: a cluster randomized trial Innovation for pandemics Diabetes is a risk factor for the progression and prognosis of COVID-19 Hospitalizations for people with type 1 and type 2 diabetes compared with the nondiabetic population of Tayside, Scotland: a retrospective cohort study of resource use The readmission rates in patients with versus those without diabetes mellitus at an urban teaching hospital Assessing the relationship between admission glucose levels, subsequent length of hospital stay, readmission and mortality Recurrent hospitalizations for severe hypoglycemia and hyperglycemia among U.S. adults with diabetes Hypoglycemia and clinical outcomes in hospitalized patients with diabetes: does association with adverse outcomes remain when number of glucose tests performed is accounted for? Hyperglycemia as a prognosis predictor of length of stay and functional outcomes in patients with acute ischemic stroke Hyperglycemia and length of stay in patients hospitalized for bone marrow transplantation Admission hyperglycemia and length of hospital stay in patients with diabetes and heart failure: a prospective cohort study Impact of hyperglycemia on morbidity and mortality, length of hospitalization and rates of re-hospitalization in a general hospital setting in Brazil Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward Frequency of hypoglycemia and its impact on length of stay, mortality, and short-term readmission in patients with diabetes hospitalized in internal medicine wards Costs and length of stay of hospitalizations due to diabetes-related complications High glucose variability increases mortality risk in hospitalized patients The relationship between diabetes mellitus and 30-day readmission rates Risk factors associated with 30-day readmission and length of stay in patients with type 2 diabetes , and MOST 109-2321-B-075A-001); and from National Health Research Institutes (NHRI-EX109-10927HT). The authors declare no conflict of interest.