key: cord-0799869-4jy0jhqj
authors: Magoon, Rohan
title: Pulmonary vasculature in COVID-19: mechanism to monitoring!
date: 2020-10-05
journal: Korean J Anesthesiol
DOI: 10.4097/kja.20536
sha: b85a3170b82316f7ccf251cbfdd3f451ce3c2e62
doc_id: 799869
cord_uid: 4jy0jhqj

nan

COVID-related ARDS. A prospective multicenter large-scale study by Kushimoto et al. [5] discovered that PVPI values ranging from 2.6 to 2.85, rendered a definitive ARDS diagnosis with a specificity of 0.90 to 0.95, while a PVPI value < 1.7 effectively ruled out a diagnosis of ARDS with a specificity of 0.95. In addition, by following the quantitative diagnosis of pulmonary edema (EVLW > 10 ml/kg), monitoring of PVPI can also assist in the management of patients with COVID-19 with associated cardiac morbidities by an augmented delineation of the cardiogenic causes (elevated EVLW with normal PVPI) from the non-cardiogenic causes (elevated EVLW and PVPI, signifying 'leaky' pulmonary capillaries).

While the results of the prospective cohort study 'Extra vascular lung water and pulmonary permeability in critically ill patients with SARS-CoV-2 (COVID-19) (PiCCOVID)' (NCT04376905) are ardently awaited, the aforementioned discussion adequately highlights that a more objective form of disease progression and therapeutic response monitoring can develop as our comprehension of the COVID-19 related pathophysiology improves.

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

Pulmonary vascular permeability indices: fine prints of lung protection?

Extravascular lung water to blood volume ratios as measures of permeability in sepsis-induced ALI/ ARDS

The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome

No potential conflict of interest relevant to this article was reported.