key: cord-0798586-03l6j31i authors: Bignamini, Elisabetta; Cazzato, Salvatore; Cutrera, Renato; Ferrante, Giuliana; La Grutta, Stefania; Licari, Amelia; Lombardi, Enrico; Midulla, Fabio; Piacentini, Giorgio; Pifferi, Massimo; Santamaria, Francesca; Tancredi, Giancarlo; Turchetta, Attilio title: Italian pediatric respiratory society recommendations on pediatric pulmonary function testing during COVID-19 pandemic date: 2020-05-24 journal: Ital J Pediatr DOI: 10.1186/s13052-020-00829-0 sha: dddc403c4e619128ea076e04a3270fa71acaaf5a doc_id: 798586 cord_uid: 03l6j31i BACKGROUND: Effective prevention and control strategies are mandatory to prevent SARS-CoV-2 infection. MAIN TEXT: The Italian Pediatric Respiratory Society promotes a series of new recommendations that should be followed in pulmonary function testing laboratories during the COVID-19 pandemic. CONCLUSION: Pulmonary function testing should be performed in children with chronic lung disease only if it is needed to guide management and limited to the necessary tests, namely spirometry. When performed, strict infection control measures should be followed due to the potential risk of transmitting SARS-CoV-2. The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern caused by a newly discovered coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) [1] . Person-toperson transmission of SARS-CoV-2 occurs primarily through close contact with an infected person, mainly occurring via respiratory droplets and after touching contaminated objects [1] . Accordingly, pulmonary function testing (PFT) could be considered at high-risk for viral transmission due to the potential for coughing and droplet formation during PFT procedures [2] . The most likely surfaces for possible contamination by this route are mouthpieces, proximal valves, and tubing. Also, both technical and clinical staff are usually in close contact with the patient during PFT for achieving optimal cooperation and best results [2] . Effective prevention and control strategies are mandatory to prevent SARS-CoV-2 infection in the PFT laboratories. The Italian Pediatric Respiratory Society (IPRS) promotes a series of new recommendations that should be followed by healthcare workers in PFT laboratories during the COVID-19 pandemic. [4] . A specific regulatory protocol has been signed on March 14th, 2020 by unions and companies in agreement with the Italian government to protect the health and safety of workers from possible infection with SARS-CoV-2 and ensure the safety of the work environment [5] . This regulatory protocol should be adopted within all workplaces, including hospital facilities, in addition to the provisions of the Italian Prime Minister's Decree of March 11th, 2020 [6] . 5. Beyond community prevention measures that comply with the WHO guidelines [7] , additional measures are necessary for healthcare professionals who perform PFT in order to preserve themselves and prevent the spreading of the virus in the health community. At this purpose, it is recommended to follow the indications delivered by the Italian "Istituto Superiore di Sanità" (ISS) Working Group on Infection Prevention and Control [8] concerning put on, use, take off and dispose of personal protective equipment, such as masks, disposable gowns, gloves, goggles or face shields, in the specific work context and job carried out. 6. All healthcare professionals should be adequately trained and updated on the risks of occupational exposure and the available prevention and protection measures. They should follow established occupational safety and health procedures, and avoid exposing themselves and others to health and safety risks. Recommendations on maintaining hygiene in a PFT laboratory are particularly relevant for protecting patients and healthcare professionals and for providing a safe and work environment [4] . 7. Patients' access (including any single accompanying person) to the areas dedicated to performing PFT should be allowed after having checked the absence of fever (body temperature < 37.5°C) and any sign/ symptom of respiratory disease (e.g., cough, shortness of breath). Patients and any single accompanying person will be asked to sanitize their hands with a hydro-alcoholic solution (or with soap and water) for at least 30 s and wear a surgical mask. Immunocompromised patients should be scheduled for testing at the start of the day, before other patients arrive, whereas infected patients should be scheduled for testing at the end of the day to prevent cross-infection. Patients/subjects should be isolated in a separate area for testing to minimize contacts with potentially infectious patients. It is very important that patients who present with acute respiratory symptoms wear a surgical mask. When applicable, a distance of at least one meter from the patient should be maintained. Measures for COVID-19 prevention and control should be engaged in addition to standard measures for preventing and controlling cross-infection acquired from the PFT laboratory. 8. Implementing hygiene control rules (handwashing, use of gloves for handling the mouthpieces or internal surfaces of the spirometer) prevents the spread of infections from the patient to healthy subjects and healthcare professionals. Sources of cross-infection in a PFT laboratory include direct contact, aerosolized particles, saliva, and skin contact. Mouthpieces have the highest risk of contamination since they come in direct contact with the patient. Mouthpieces need to be replaced after every use to minimize the risk of cross-infection. Overall, to perform PFT, disposable materials (filters, mouthpieces, nose clips, flow sensors) should be discarded after a single use. Where reusable items are utilized, they should be managed carefully and should be thoroughly cleaned and disinfected as recommended by manufacturers and local infection control policy. 9. We recommend enhanced cleaning and disinfection procedures for both the PFT laboratory and equipment. The testing space and equipment should be cleaned with chlorine solutions at a concentration of 1000 ppM or with polyphenol solution at a concentration of 1%, according to the manufacturer's indications. Biological waste should be handled appropriately and disposed to reduce the risk of cross-infection. Separation of infectious and noninfectious waste help to control infection. Solid infectious waste should be discarded in containers labelled with the universal symbol of biological hazards. Routine cleaning of floors with detergent and water is recommended as dust and dirt may neutralize the action of disinfectant or sterilant. Therefore, disinfection should always be undertaken with a detergent cleaner [9] . 10. Pressurized metered-dose inhaler (pMDI) via a spacer should be considered the preferred device for the administration of any drugs (e.g., salbutamol). The use of nebulizers should be avoided to decrease the risk of disseminating COVID-19 to other patients and to physicians, nurses and other personnel in the laboratory, unless an airborne infection isolation room is available [10] . Spacers should not be shared among patients. COVID-19 is an emerging, rapidly evolving situation, and the IPRS is following developments closely. During the COVID-19 containment phase, the IPRS recommends avoiding routine PFT and limiting to the necessary tests, namely spirometry. PFT should be performed in children with chronic lung disease only if it is needed to guide management and if comprehensive infection control can be maintained in the PFT laboratories. When performing PFT, strict infection control measures should be followed. Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy. 3 Department of Pediatrics, Bambino Gesù Children's Hospital 11 Department of WHO. Coronavirus disease (COVID-19) Pandemic. 2020 Pulmonary Function Laboratories: Advice regarding COVID-19 Discharge criteria for confirmed COVID-19 cases. ECDC technical report COVID-19) outbreak: rights, roles and responsibilities of health workers, including key considerations for occupational safety and health COVID-19 -Sicurezza dei lavoratori Decreto del Presidente del Consiglio dei Ministri 11 marzo 2020 Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected: interim guidance Indicazioni ad interim per un utilizzo razionale delle protezioni per infezione da SARS-COV-2 nelle attività sanitarie e sociosanitarie (assistenza a soggetti affetti da covid-19) nell'attuale scenario emergenziale SARS-COV-2 Task Force of Pulmonary Function Testing and Clinical Respiratory Physiology, Chinese Association of Chest Physicians; Pulmonary Function Testing Group Staff safety during emergency airway management for COVID-19 in Hong Kong Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. All authors contributed equally to this work. All authors read and approved the final manuscript. No funding was received for this work.Availability of data and materials Not applicable.Ethics approval and consent to participate Not applicable. Not applicable. The authors declare that they have no competing interests.Author details 1