key: cord-0798262-f5xcgp3l authors: Fontanella, F.; Hannes, S.; Keating, N.; Martyn, F.; Browne, I.; Briet, J.; McAuliffe, F.M.; Baalman, J.H. title: COVID-19 infection during the third trimester of pregnancy: Current clinical dilemmas date: 2020-05-29 journal: Eur J Obstet Gynecol Reprod Biol DOI: 10.1016/j.ejogrb.2020.05.053 sha: d94f031c61fbba50dc5cf6947a8188c953879bd5 doc_id: 798262 cord_uid: f5xcgp3l nan weeks with cough, dyspnea and oxygen desaturation (table 1) . Oxygen support and molecular weight heparin (LMWH) was started and nasopharyngeal swab was found negative for SARS-Cov-2. Because of high suspicion of COVID-19 infection, a CT scan was performed and showed bilateral ground glass opacities suggestive of COVID-19 pneumonia (figure 1). Later the same day, second sample of PCR swab came back positive for SARS-Cov-2. After a multidisciplinary meeting, antenatal corticosteroids for fetal lung maturation were administered in order to optimize the fetus' state if a preterm cesarean section would be required because of sudden maternal respiratory deterioration. Hydroxychloroquine was also commenced. On day 5, we observed a rapid improvement of patient's symptoms, oxygen support was no longer needed and patient was discharged home. Patient B. A 29-year old self-presented at 40 weeks gestation with cough, sore throat and diarrhea (table 1). Swab for SARS-CoV-2 was pending and chest X-ray showed no signs of consolidation. Following multidisciplinary discussion, a cesarean delivery was performed in view of maternal fever, fetal tachycardia and previous cesarean section. A live male infant was delivered with Apgar of 9 and 9 and no signs of fetal distress. On day 2 of hospitalization patient was afebrile and discharged home with thromboprophylaxis. On day 4 post-delivery, SARS-CoV-2 swabs returned as positive. The baby did not develop respiratory symptoms. Hereby we discuss our clinical managements and multi-disciplinary considerations concerning time of delivery, use of antenatal corticosteroids and thromboprophylaxis. When dealing with a critically ill patient, the question arises whether or not delivery of the infant would improve maternal outcome. For both our cases, a multidisciplinary discussion was held for this purpose and led to the administration of antenatal corticosteroids in case A (preterm) and to an emergency cesarean section in case B (term). In the literature, reports on non-COVID-19 ARDS suggest a high mortality rate, of almost one third amongst pregnant and postpartum women (1), however it is still unclear whether delivery could significantly improve maternal outcome (1) (2) (3) . Previous studies reported an increased maternal morbidity in pregnant women compared to non-pregnant women, though no significant difference in mortality has been found (2, 4). In a retrospective review of 29 mechanical ventilated pregnant women, only a modest improvement in maternal respiratory function was seen after delivery of the infant (3). A number of further practical factors need to be considered. First of all, the risk of a failed endotracheal intubation is eight times higher during pregnancy due to airway edema, anatomic changes and increased weight (5) . This was considered in both our patients with type III obesity. Secondly, emptying of the uterus could constitute an advantage by reducing oxygen consumption and by allowing prone positioning and a wider range of therapies without concern for fetal wellbeing. Perinatal deaths in third-trimester pregnant patients with ARDS has been reported in up to 23% (1). To conclude, appropriate management should be evaluated on a case by case basis, according to maternal status, gestational age and maternal prognosis (6, 7) . The main goal of obstetric specialists should be thus finding a subtle balance between maintaining adequate maternal saturation (PaO2 > 70 mmHg equivalent to oxygen saturation >95%) (8) and minimizing the risks of iatrogenic preterm birth and emergency cesarean section. These last J o u r n a l P r e -p r o o f two points should be emphasized as a high rate of preterm births and cesarean sections in patients with COVID-19 has been recently reported (9) . In the light of a recent meta-analysis reporting preterm births in 41% of COVID-19 infections, use of antenatal corticosteroids constitutes a second relevant and debated topic. In fact, steroids are not recommended in COVID-19 infection outside of clinical trial because of potential increased risk of mechanical ventilation (10) . However, literature solely refers to the standard use of steroids in non-pregnant patients with different dosages and duration of treatment than those standardly used for fetal indication (11) . Neither observational studies nor case-reviews on corticosteroids for fetal indication in COVID-19 have been published. To our knowledge, we are the first to report a case of COVID-19 pneumonia where a short course of antenatal corticosteroids was administered for fetal indication. Although steroids administration led to an exacerbation of pre-existent gestational diabetes, a favorable maternal outcome was observed without aggravation of her COVID pneumonia. To sum up, no clear evidence of harm has been reported so far and antenatal corticosteroids in COVID-19 have been advised when usually offered by the Royal College of Obstetricians and Gynaecologists and certainly for delivery prior to 34 (6) . Similarly, American College of Obstetricians and Gynecologists recommended administration of corticosteroids until 33+6 weeks because of the well-established benefit on neonatal morbidity and mortality (7) . In our case series, thromboprophylaxis was promptly started from day 1 in case A, and postpartum in case B. Current belief is that Covid-19 immune response may cause a procoagulant state re-named COVID-19-associated coagulopathy (CAC), which has been associated to increased mortality and suggested as major pathogenic factor of SARS-CoV-2 (12) . Considering that pregnancy constitutes itself a prothrombotic state (13) , pregnant patients would constitute a high-risk population in this context. Heparin besides its anticoagulant effect could also present an anti-inflammatory and antiviral effect by binding the S-protein of SARS-CoV-2 and its use has been recently associated with increased survival (14) .The American Society of Hematology has therefore recommended LMWH prophylaxis for COVID-19 patients, unless of actively bleeding or with severe thrombocytopenia (15, 16) . The use of LMWH in pregnant women is broadly implemented in standard care. These considerations therefore constitute an argument to treat pregnant women with prophylactic LMWH once COVID has been diagnosed (13) . Financial Support: No financial support was received for this study Patient's consent has been obtained for publishing this case series. 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