key: cord-0797454-nec12z61 authors: Barsoum, Zakaria title: Pediatric Asthma & Coronavirus (COVID-19)-Clinical Presentation in an Asthmatic Child—Case Report date: 2020-05-19 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00310-3 sha: 6fe1d1860d00bb79a8914c0134f5fb61075b1ef3 doc_id: 797454 cord_uid: nec12z61 Pandemic coronavirus (COVID-19) is a novel virus that causes severe pneumonia. Elderly people with co-morbidities are at risk of severe disease. Symptoms are generally milder in children. We present an asthmatic 12-year old girl with cough, wheeze, and mild pneumonia due to COVID-19. Reverse transcription (RT) polymerase chain reaction (PCR) confirmed COVID-19 on nasopharyngeal sample. Chest radiograph revealed bronchopneumonia. Frequent salbutamol inhalers were administered for treatment. Case was discharged home 2 days following hospitalization. COVID-19 may present with mild pneumonia in children or with an exacerbation of asthma in asthmatic children. Additional observations of clinical presentations of COVID-19 in children are recommended. Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus that was first recognized in Wuhan, China, and is closely linked to the Severe Acute Respiratory Infection (SARS) virus. [1] COVID-19 causes mild disease in the majority of cases; however, approximately 14% develops severe disease requiring hospitalization and oxygen support, and 5% requires admission to an intensive care unit. [1] Complications include acute respiratory distress syndrome (ARDS), sepsis, septic shock, and multi-organ failure [2] and the risk is higher in old age groups with comorbidities such as asthma, diabetes, and heart disease [3] . Critically ill patients will require mechanical ventilation [2, 4, 5] . Hypotonic solutions should be avoided in the management of COVID-19 [4] . The most common diagnosis in severe COVID-19 patients is severe pneumonia. To date, little is known about clinical presentation in children and infants where cough and fever are generally milder than adults and viral co-infection may occur [5] [6] [7] . Specimens from both the upper respiratory tract (URT; nasopharyngeal and oropharyngeal) AND, from the lower respiratory tract (LRT) when available such as sputum and endotracheal aspirate, are most preferably and should be sent for COVID-19 virus testing by reverse transcription real-time-(RT)-polymerase chain reaction (PCR) and for bacterial cultures. Viral shedding in survivors was 37 days at the longest [3, 8] . Two negative URT and LRT samples, at least 24 h apart, may indicate viral clearance in hospitalized and clinically recovered patients; LRT are more likely to be positive and for a longer period [9] . There is no current evidence to recommend any specific anti-COVID-19 treatment for patients with confirmed COVID-19. No evidence to date suggests that young people with asthma are at increased risk for COVID-19 infection [10, 11] . However, there is a theoretical possibility that a child with asthma infected with COVID-19 could experience an asthma exacerbation and serious morbidity due to combined effects on the respiratory tract [10, 11] . We present a 12-year old girl with confirmed COVID-19 with the underlying diagnosis of asthma, who presented initially Case was admitted to hospital on day 6 of illness. Chest X-ray revealed tiny patches of opacities and was reported as bronchopneumonia. Nasopharyngeal MutaPLEX coronavirus realtime RT-PCR for SARS Coronavirus 2 and other SARSrelated Betacoronaviruses confirmed COVID-19 infection on day 6 of illness. Frequent salbutamol inhalers were administered in the hospital. No oxygen was required. Symbicort inhalers were given. Oral prednisolone was given in accident and emergency department which stopped the following day when COVID-19 was confirmed. Case improved and was discharged after 2 days. Case was not retested for COVID-19 prior to hospital discharge, but parents were notified and advised to self-isolate for 14 days and 8 days of child self-isolating as per the guidelines from Public Health Agency in our country. Symptoms of pandemic COVID-19 are generally milder in children than adults. [5] [6] [7] Pandemic COVID-19 may present with mild pneumonia in children. Although there is a paucity of literature on pediatric risk factors, the case series to date from Wuhan on hospitalized pediatric cases do not list asthma as a pre-existing risk factor for morbidity or mortality. [11] We presented a 12-year old girl with underlying asthma who presented with mild pneumonia secondary to COVID-19. We have demonstrated that children with underlying comorbidities such as asthma may be at a greater risk of COVID-19 similar to adults with other comorbidities [3] . Though there is minimal literature on the risk that COVID-19 could trigger a viral induced exacerbation of asthma in asthmatic children [11] and little is known about COVID-19 clinical presentations in children to date, we have demonstrated that COVID-19 may present with a clinical picture of asthma or asthma exacerbation in asthmatic children, with cough; wheeze, and breathing difficulties. Nebulizers may increase the risk of disseminating COVID-19; therefore, our case was managed with inhalers (as per Global Initiative for Asthma (GINA) report released on 25 March 2020 on asthma management when COVID-19 is confirmed or suspected.). Nebulizers may also increase the risks of viral lower lung deposition [11] and by stimulating cough reflex may increase risk of transmission to healthy contacts. [11] Oral corticosteroids may prolong COVID-19 clearance, and their use in the management of asthma in children infected with COVID-19 was not recommended both by WHO and the Centers for Disease Control (CDC) in the USA. [11] Therefore, oral corticosteroids were discontinued once the diagnosis of COVID-19 was confirmed. Additional observations of clinical presentations of COVID-19 in children are recommended. Competing Interests The authors declare that they have no competing interests. Ethical Approval Ethical approval was obtained from the director of Northern Ireland Clinical Research Network-Western Health and Social Care Trust (WHSCT) Informed Consent Consent was obtained from parents. 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