key: cord-0797299-b0mb01ba authors: Junior, Henrique Pott; Cominetti, Marcia Regina title: Comorbidities predict 30-day hospital mortality of older adults with COVID-19 date: 2021-06-19 journal: Geriatr Nurs DOI: 10.1016/j.gerinurse.2021.06.011 sha: bece3c5d7ddadd9aca088913939379446affd2b2 doc_id: 797299 cord_uid: b0mb01ba We evaluated whether comorbidities predict disease severity and mortality in a cohort of 147 older adults with COVID-19. Patients were divided into three groups according to the Charlson Comorbidity Index (CCI) score. Groups 2 (CCI 4 – 5) and 3 (CCI ≥ 6) had higher 30-day mortality rate as compared to group 1 (CCI ≤ 3). Cox regression showed that even after adding sex, National Early Warning Score (NEWS) 2 score and the need for intensive care unit admission to the model, no significant changes were found in the mortality risk predicted by the CCI score, showing that chronic pathologies are key determinants of short-term survival in COVID-19. This work is important for the geriatric nursing field as it demonstrates that alternative approaches for clinical decision-making that consider the comorbidities, rather than only chronological age, can be especially significant for the management of COVID-19 patients’ hospitalization. Over one year has passed since severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first described, and yet only a slight improvement in controlling the viral spread has been reported (1) . With more than 100 million reported cases of infection, the coronavirus 2019 disease (COVID- 19) reached pandemic status in March 2020, imposing an extensive burden on public life and health care worldwide (2). After a relatively short period of incubation, most SARS-CoV-2 infected individuals develop mild to moderate influenza-like symptoms and about 20% of them develop a severe inflammatory-mediated hypoxemic disease that resembles a cytokinestorm syndrome (3) . Most cases involve men, aging between 30 and 79 years, with one or more coexisting medical conditions (4) (5) (6) (7) (8) . According to a systematic review, the most prevalent associated diseases are hypertension (32%), obesity (25%), diabetes (18%), and cardiovascular disease (16%), whereas COVID-19 patients with chronic kidney or other renal diseases (51%, 44%), cerebrovascular accident (43%, 44%), and cardiovascular disease (44%, 40%) had more severity and mortality respectively. Additionally, substantial variation in the prevalence of comorbidities and associated disease severity and mortality in different geographic regions was observed, with the highest mortality in Latin American and European patients with any medical condition, mostly male older adults (9) . Moreover, studies have also shown that older adults are more likely to develop severe respiratory disease that requires hospitalization or even die (6) . However, we frequently observe in clinical practice that the disease become more intense depending upon the number of clinically significant comorbidities, rather than age itself (10). Thus, considering that older adults face a greater number and severity of different chronic diseases, as well as immune disfunction (11) , the purpose of the present study was to determine whether a Charlson Comorbidity Index (CCI) would reflect disease severity and all-cause 30-day mortality in a cohort of older adults with COVID-19. This is an ongoing observational study conducted at the University Hospital of the Federal University of São Carlos (HU-UFSCar). In this report, 147 patients with 60 years and older admitted for COVID-19 to the respiratory ward were included in the analysis. The study was conducted according to the guidelines laid down in the Based on previous studies on the association between CCI score and mortality in COVID-19 patients, we calculated a sample size of at least 40 participants per group assuming a hazard risk (HR) for mortality of at least 1.85 in the CCI score > 3 groups as compared to the CCI score ≤ 3 groups, with 80% of power and an alpha error of 5% (13) . Continuous data are presented as mean ± standard deviation or median [ A total of 147 adults were included in this study. Mean age was 74.9 years old (range, 60 -99 years) and half of the subjects were females (50.3%). Most of the subjects were hypertensive (61.2%) and frail (64.6%), but not diabetic (40.1%) nor they had cardiovascular diseases (23.8%), nor chronic lung diseases (17.7%), nor they were affected by dementia (11.6%). Table 1 summarizes overall baseline demographic and clinical characteristics of the study sample. The median time from symptom onset to hospital admission was 7.5 [5, 11] days, and more than a half of the patients were classified as having a severe disease on comparisons with group 2 and 3, respectively). (Figure 2) The Kaplan-Meier curves for survival probability are shown in Figure 3 . Patients from groups 2 and 3 presented a lower survival rate with faster time-to-event as compared to group 1 (p = 0.009 at overall log-rank test). Subgroup analysis showed a significant difference between groups 1 and 2 (p = 0.03) and groups 1 and 3 (p = 0.005). No significant difference in survival rate was found between groups 2 and 3. Cox regression model showed that the CCI score predicts 30-day mortality among older adults with COVID-19 (HR = 1.27, 95% CI 1.01 to 1.60; p = 0.03). We also estimated the HR adjusted (aHR) for sex, NEWS2 score at hospital admission and the need for ICU admission during hospitalization ( This retrospective study demonstrated that a high comorbidity index is independently associated with 30-day hospital mortality rate, implying that chronic pathologies and less functional reserve are key determinants of short-term survival in COVID-19 patients. Some epidemiological studies have shown that the mortality pattern of COVID-19 patients has strong associations with age, besides pre-existing comorbidities and male-sex (14, 15) , while others report that older age, severity of respiratory failure and renal impairment at presentation, but not comorbidities, are predictors of 28-day mortality in these patients (16) . Notably, a recent study showed that an age-adjusted CCI (aCCI) threshold > 3.5 yielded the best cut-off point for predicting mortality in COVID-19 patients (17), whereas other studies have shown that neither comorbidities nor chronological age were powerful predictors of disease prognosis and outcomes (18) . All these findings can result from different study designs and/or populations, or due to the influence of confounding factors. Nevertheless, they point out to the vast outcomes heterogeneity among persons infected with SARS-CoV-2 and highlight how much we still need to understand from this complex disease. Aging and comorbidities are characterized by a higher basal proinflammatory status (inflammaging) linked with a progressive failure of the immune system to initiate proper responses (immunosenescence) (19) . An age-related gut dysbiosis has also been reported as cause of an imbalanced immune response and overreactive inflammatory phenotype in SARS-CoV-2 infection. (20) Moreover, other factors such as age-related increase in endothelial damage and changes in clotting function; higher density, increased affinity and different distribution of angiotensin converting enzyme 2 (ACE2) receptors and transmembrane serine protease 2; lower vitamin D levels (21) ; and mitochondrial disfunction are also proposed as conditions that increase the severity of the disease in older adults (22) . Having in mind that the age of COVID-19 patients has been proposed as a way to determine who will receive intensive care admission when critical care resources are limited (23) , this work provides evidence that an alternative approach may be adopted, considering the comorbidities of the patients, rather than only their age and arguing against the idea that few-sizes-fit-all decision-making resolutions. This observation can be especially important in aged but healthy older adults, who have been described as having much lower risk of COVID-19 mortality (24) . Accordingly, in older adults without comorbidities, age was not a predictor of disease severity with structural factors, such as poverty and low socioeconomic status, playing a larger role. Notably, in the same study, mortality prediction in individuals without comorbidities improved only marginally when considering chronological age added to structural factors (25) . Our results can contribute to avoid negative age stereotypes associated with older persons' rejection of COVID-19 hospitalization (26) . This is in strong agreement with previous works (25, 27) , showing that age alone is not enough to drive decisions to limited health-care resources during COVID-19 pandemic. There are some limitations in this study, which include its single-centered characteristic and the relatively small sample size, which may limit the interpretation of the results. In addition, information on medical history, symptom onset, severity of each comorbidity, socioeconomic status, as well as specific treatment received before admission to hospital reported by the patients are susceptible to bias. Despite these limitations, the use of appropriate statistical tools allowed to identify comorbidity as an independent factor associated with 30-day hospital mortality in COVID-19 patients. Chronic pathologies and less functional reserve are key determinants of shortterm survival in COVID-19, rather than age itself. Taken together, these findings suggest that not all older patients have the same prognosis, and point to the importance to consider comorbidities, rather than only their age for clinical decision-making regarding COVID-19. This can be especially important for healthy older adults and contribute to avoid negative age stereotypes associated with rejection of COVID-19 hospitalization. This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The sponsor had no role in the design, methods, data collection, analysis, and preparation of the article. 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