key: cord-0797058-u8ejx5q5
authors: de Souza Pereira, Mel Amélia; Rezende‐Silva, Erika; Barbosa, Breno Ferreira; de Albuquerque, Hélio Igor Melo; de Almeida Souza, Liane Maciel; da Mota Santana, Lucas Alves
title: Neurological, haemodynamic and metabolic disturbs are prevalent symptoms in oral surgeons with post‐COVID‐19
date: 2022-03-07
journal: Oral Surg
DOI: 10.1111/ors.12734
sha: 0ce8d80bdbf1285dae901851432635bcbec0f9d4
doc_id: 797058
cord_uid: u8ejx5q5

nan

Consequently, a wide spectrum of neuropsychiatric manifestations has been described, such as encephalitis, encephalopathy, neuromuscular junctions disorders and even Guillain-Barré syndrome. 6 The most commonly observed neurological alterations in patients after initial infection and independent of disease severity grade include 'brain fog', a subtype of cognitive dysfunction as well as anxiety and depression. 7 In contribution, several studies have demonstrated the neuroinvasive potential of the novel coronavirus and its neurotropic capacity to induce neuronal death and dysfunction of astrocytes as observed in vitro study models. 8, 9 Possibly, this mechanism may explain the main alterations observed in the nervous system level by most of the oral surgeons in our team.

In contrast, metabolic and haemodynamic disorders caused by the pathogen correspond to escape alternatives of the host's immune response, inducting severe tissue inflammation. 10, 11 Also, SARS-CoV-2 is able of infects the pancreas through affinity for the ACE2 receptor triggering cellular damage to the organ's parenchyma and, thereafter, influencing insulin secretion and development of hypoglycemic frame, even in patients with no history of diabetes mellitus. 11 Regarding that, Pasquarelli-do-Nascimento et al. 12 reiterate that hypercoagulopathy and adipose tissue may exacerbate the inflammatory response of individuals predisposing higher risk of mortality, especially in more susceptible individuals.

To conclude, the post-COVID-19 frame may impact directly the physical and cognitive performance of patients and health professionals. Additionally, it might cause a significant decrease in quality of life, even daily activities. Therefore, it is crucial to develop methods and reliable tools for detecting this new clinical condition, especially emphasizing rehabilitation therapies and continuous follow-up to minimize possible sequels.

None.

None to declare.

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