key: cord-0795787-8f0mann8
authors: Sprow, Grant; Dan, Joshua; Abbott, James; Jiang, Angela; Diaz, DeAnna; Vazquez, Thomas; Kodali, Nilesh; Werth, Victoria P.
title: SCLEROTIC SKIN DISEASE DEVELOPMENT FOLLOWING COVID-19 VACCINATION
date: 2022-02-23
journal: JAAD Case Rep
DOI: 10.1016/j.jdcr.2022.02.008
sha: c3e9a502ea90e373bcd4289d9a20b48eb48e037e
doc_id: 795787
cord_uid: 8f0mann8

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Vaccination is an essential preventative measure against the spread of certain infectious diseases. 23

However, there may be an association between vaccination and subsequent autoimmune reactions 1 . 24 We present two cases of patients with prior autoimmune skin disease progressing to new-onset sclerotic 25 skin disease following mRNA COVID-19 vaccination. To our knowledge, this pattern has never been 26 reported in the literature and represents potential COVID-19 vaccine adverse effects of which clinicians 27 should be aware. 28 29 Case Report 30 Case 1: A 60-year-old female patient with a 14-year history of discoid lupus presented six weeks after 31 the first dose of the Moderna COVID-19 vaccine with severe widespread muscle pain and a new rash 32 that she initially noticed two weeks after the first dose of the vaccine. The second vaccine dose was 33 given four weeks after the first, and the patient did not notice any change in her rash or muscle pain 34 temporally associated with the second dose. Treatment for her lupus prior to presentation included 35 hydroxychloroquine 400 mg/day and clobetasol 0. 

Vaccination and autoimmune disease: what is the 133 evidence? The Lancet

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COVID-19 vaccination

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Postvaccination morphea profunda in a child. Pediatric 142 dermatology

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