key: cord-0794405-w4fyp9xx
authors: Zhang, A.; Breznik, J. A.; Clare, R.; Nazy, I.; Miller, M. S.; Bowdish, D. M. E.; Costa, A. P.; Group, COVID-in-LTC Study
title: Antibody Responses to 3rd Dose mRNA Vaccines in Nursing Home and Assisted Living Residents
date: 2021-12-18
journal: nan
DOI: 10.1101/2021.12.17.21267996
sha: 4cb6d397a1c35cdbfe822811eabe90b64a7ff5b2
doc_id: 794405
cord_uid: w4fyp9xx

A comparison of SARS-CoV-2 wild-type and the beta variant virus neutralization capacity between 2 and 3 mRNA vaccine series in nursing home residents, and between nursing home and assisted living residents strongly supports 3rd dose vaccine recommendations, and equivalent polices for nursing homes and assisted living settings. Findings suggest that residents mount a robust humoral response to a 3rd mRNA vaccination, and have greater neuralization capacity compared to a 2 dose series.

Additional Information: Data in this study were collected by the COVID-in-LTC Study Group. . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. 

In this serial cross-sectional analysis, we examined SARS-CoV-2 neutralizing antibody titers after both 2 nd and 3 rd vaccination in nursing home residents, and after 3 rd vaccination in assisted . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. 

. CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. 

. CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) preprint Our data strongly support 3 rd dose vaccine recommendations, and equivalent polices for nursing homes and assisted living settings. Consistent with non-frail populations 5 , our findings suggest that residents mount a robust humoral response to a 3 rd mRNA vaccination, with greater neuralization capacity compared to a 2 nd dose series. Continued monitoring of neutralization titers over time will determine the rate of degradation. Neutralization performance for the beta variant may not mimic performance for the omicron variant, which at time of writing remains a concern.

. CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) preprint 

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