key: cord-0793663-tfz178yi
authors: Zhao, Yi; Xia, Zhaohua; Liang, Wenhua; Li, Jianfu; Liu, Lei; Huang, Danxia; Xu, Xin; He, Jianxing
title: SARS-CoV-2 Persisted in Lung Tissue Despite Disappearance in Other Clinical Samples
date: 2020-05-22
journal: Clin Microbiol Infect
DOI: 10.1016/j.cmi.2020.05.013
sha: fa1b7960aeae39007ef2d62314f514952a6e65d5
doc_id: 793663
cord_uid: tfz178yi

nan

The latest version of the criteria for hospital discharge in China and many other countries [1, 2] commonly demands (a) normal temperature lasting longer than 3 days, (b) substantially resolved respiratory symptoms, (c) substantially improved acute exudative lesions on chest radiographs, and (d) 2 consecutively negative results of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests on respiratory tract samples separated by at least 24 hours. However, negative results of RT-PCR tests in a proportion of patients discharged based on this criteria have, at follow-up exams, returned positive [3] [4] [5] , resulting in a raised concern that a proportion of discharged patients may still be virus carriers.

On January 11, 2020, a 66-year-old man with an 8 year history of hypertension was admitted to The Third People's Hospital of Shenzhen, Shenzhen, China, as a probable case of COVID-19 due to his recent one-week travel history to Wuhan and symptoms of fever and cough. Upon admission, the patient was immediately isolated. Low/high-flow nasal cannula oxygen, antiviral (oseltamivir 75 mg and interferon alfa-1b 30ug, twice daily), and antibiotic 

National Health Commission & National Administration of Traditional Chinese Medicine

European Centre for Disease Prevention and Control. Guidance for discharge and ending isolation in the context of widespread community transmission of COVID-19 -first update

Positive RT-PCR Test Results in Patients Recovered From COVID-19

SARS-CoV-2 turned positive in a discharged patient with COVID-19 arouses concern regarding the present standard for discharge

We thank the specialist team in organ transplantation from The First