key: cord-0790970-e8ohc25w
authors: Wu, Qiuji; Chen, Tielong; Zhang, Hongyan
title: Recovery from COVID‐19 in two patients with coexisted HIV infection
date: 2020-05-13
journal: J Med Virol
DOI: 10.1002/jmv.26006
sha: e7c71b11eb2fa615042e74a6906544e726b3ddf0
doc_id: 790970
cord_uid: e8ohc25w

COVID‐19 has become a global health concern. HIV‐infected patients are particularly vulnerable to COVID‐19 due to their immune‐compromised status. The clinical manifestations and clinical outcomes of these patients are not clear. In this report, we presented two special COVID‐19 patients with HIV infection and other comorbidities. We described the clinical characteristics, clinical manifestations, treatments and clinical outcomes of both patients. One patient with prior HIV‐infection continued anti‐HIV treatment when diagnosed with COVID‐19. The other patient was newly diagnosed with HIV‐infection when diagnosed with COVID‐19 and had not begun anti‐HIV treatment. Both patients were treated with anti‐viral, antibiotics, oxygen treatment and supportive care and recovered from severe pneumonia. The experience of these two cases suggested that COVID‐19 patients with HIV infection could still have satisfactory clinical outcomes following proper medical care. This article is protected by copyright. All rights reserved.

On January 20 2020, a 60-year-old male patient presented with generalized myalgia for 2 weeks and intermittent fever around 38.3°C for 5 days and was admitted in our hospital ( Figure 1A , Patient 1). Before admission, he had accomplished a chest computed tomography (CT) scan on January 18 2020 that showed bilateral multiple ground-glass opacities (GGO), prominent on the right lower lobe ( Figure 1B, Patient 1) . The test of influenza virus was negative. Blood cell counts were: leukocyte, 3.41×10 9 /L; neutrophil, 2.25×10 9 /L; lymphocyte, 0.9×10 9 /L; red blood cell, 3.62×10 12 /L; platelet, 95×10 9 /L. The hemoglobin was 125 g/L. Other clinically cured for COVID-19 and was discharged on February 3 ( Figure   1A , Patient 1). He was asked to keep isolated at home for another two more weeks before he comes for a review of his disease. A Chest CT on April 2 shown a significant improvement of pneumonia ( Figure 1B 

A 47-year-old male patient attended our hospital after seven days of fever and non-productive cough on Feburary 18, 2020. He had a highest body temperature of 39.8°C and generalized myalgia, sore throat, cough, intermittent shortness of breath, and diarrhea. He had performed chest CT scan in local hospital which revealed bilateral multiple GGO. The SARS-Cov-2 RNA test was positive ( Figure 1A, Patient 2) .

After admission, a chest CT scan showed increased pulmonary exudative lesions on Feburary 20 ( Figure 1B, Patient 2) . Blood cell counts were: leukocyte, 10.51×10 9 /L; neutrophil, 9.09×10 9 /L; lymphocyte, 0.67×10 9 /L; This article is protected by copyright. All rights reserved.

Accepted Article red blood cell, 3.99×10 12 /L; platelet, 302×10 9 /L. The hemoglobin was 122 g/L. PCT was 0.05 ng/ml and D-dimer was 210 ng/ml. Figure 1B, Patient 2) . He had no fever, cough, myalgia but still had some dyspnea after labor. He was discharged on March 16 and was asked keep isolated at home for another two more weeks before he comes for a review of his disease. He was recommended to pursue anti-HIV treatment after recorvery from

This article is protected by copyright. All rights reserved. 

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The authors declare that there are no conflicts of interest in this work. This article is protected by copyright. All rights reserved.

The authors are grateful to both patients who assisted in the implementation of the study.

The study was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University (2020089K).

Accepted Article