key: cord-0789587-y4ppnxyn
authors: Bustos B, Raúl; Jaramillo-Bustamante, Juan Camilo; Vasquez-Hoyos, Pablo; Cruces, Pablo; Díaz, Franco
title: Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2: A Case Series Quantitative Systematic Review
date: 2020-11-12
journal: Pediatr Emerg Care
DOI: 10.1097/pec.0000000000002306
sha: c19b9a81a7c14d126366e83dc10f3fc043b39c0d
doc_id: 789587
cord_uid: y4ppnxyn

Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July 1, 2020. We found a myriad of clinical features, but we were able to describe common characteristics: previously healthy school-aged children, persistent fever and gastrointestinal symptoms, lymphopenia, and high inflammatory markers. Clinical syndromes such as myocarditis and Kawasaki disease were present in only one third of cases each one. Pediatric intensive care unit admission was frequent, although length of stay was less than 1 week, and mortality was low. Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low. The PIMS-ST was recently described, and the detailed quantitative pooled data will increase clinicians’ awareness, improve diagnosis, and promptly start treatment. This analysis also highlights the necessity of future collaborative studies, given the heterogeneous nature of the PIMS-TS.

We evaluated relevant studies in PubMed, LILACS, and Embase, published between May 1 to July 1, 2020, using combinations of the terms "pediatrics," "coronavirus," "COVID-19," "SARS-CoV-2," "pediatric intensive care," "pediatric inflammatory multisystem syndrome," "Kawasaki disease," and "hyper-inflammatory· Kawasaki · PIMS-TS · MIS-C · COVID-19 · SARS-CoV-2". We retrieved studies with at least 3 patients, and pediatric age was considered younger than 21 years. We excluded studies that had duplicate patients from other reports. Quality of measures was assessed by the tool developed by Murad et al. 27 Data extraction was performed by 2 independent reviewers (R.B.B. and J.C.J.-B.). Data were initially described by study using the presented measurement of distribution on the original paper. A meta-analysis was carried out if the variable of interest was present in more than 50% of studies. Detailed method for quantitative meta-analysis is available in supplementary file 1, http://links.lww.com/PEC/A653. 8.5-9.9) , and all patients were febrile at presentation. Rash was reported in 58% (95% CI, 52%-63%), conjunctivitis in 56% (95% CI, 42%-69%), and shock in 76% (95% CI, 55%-93%). A positive test for SARS CoV-2 was available in reverse transcription polymerase chain reaction (RT-PCR) 38% (95% CI, 29%-46%), serology 68% (95% CI, 50%-84%), and a known positive contact in From the *Unidad de Cuidados Intensivos Pediátricos, Clínica Sanatorio Alemán y Hospital Guillermo Grant Benavente, Concepción, Chile; †Unidad de Cuidados Intensivos Pediátricos, Hospital General de Medellín; ‡Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Medellín; §Departamento de Pediatría, Universidad Nacional de Colombia; ||Departamento 29% (95% CI, 14%-47%). Twenty-six percent (95% CI, 13%-40%) of cases fulfilled the American Heart Association Kawasaki Disease criteria, whereas 29% (95 CI, 3%-66%) developed myocarditis. Pooled laboratory test data are shown in Table 2 . Markers of inflammation and cardiac injury were frequently elevated. Chest x-ray or lung CT scan showed pulmonary infiltrates in 41% (95% CI, 36%-47%). Left ventricular dysfunction by echocardiogram was found in 72% (95% CI, 52%-89%), abnormalities in the coronary arteries in 24% (95% CI, 11%-39%), and pericardial effusion or pericarditis in 24% (95% CI, 12%-39%). Thirty-seven percent (95% CI, 3%-60%) reported electrocardiographic alterations.

Overall, 82% (95% CI, 68%-93%) of the patients required intensive care (Fig. 1A) , 62% (95% CI, 250%-73%) received vasoactive drugs (Fig. 1B) , and 59% (95% CI, 40%-77%) received respiratory support (Fig. 1C) , such as invasive mechanical ventilation in 27% (95% CI, 15%-41%; Fig. 1D ), noninvasive ventilation in 9% (95% CI, 2%-20%), and high-flow nasal cannula in 6% (95% CI, 0%-17%). Twenty-five patients were placed on extracorporeal membrane oxygenation (ECMO). Only 1 patient required renal replacement therapy.

Intravenous immune globulin was used in 79% (95% CI, 66%-90%) of patients, followed by steroids in 47% (95% CI, 34%-59%). Other therapies where use more inconsistently like aspirin (36% studies; range. 20%-100% of cases), anticoagulants (27% studies; range, 47%-100%), tocilizumab/siltuximab (36% studies; range, 5%-80%), infliximab (18% studies; range, 5%-14%), anakinra (45% studies; range, 5%-33%), and antibiotics (45% studies; range, 67%-100%). Remdesivir use was not reported in the analyzed studies. Standardized ICU length of stay (LOS) was 6 days (95% CI, 4-7 days) with an overall hospital stay of 9 days (95% CI, 7-11 days). A total of 7 deaths occurred, 5 of them during ECMO run.

Eighty-one children (17.6%) were still hospitalized at the time the case series were reported.

In this systematic review of PIMS-TS cases in the literature, we found a great deal of heterogeneity. The cases reported are numerous, from several centers, but there is no standardized description of the variables of interest. We analyzed 11 case series, including 468 children from 196 centers. Instead of listing studies and patients, we performed a quantitative analysis according to the weighed cases of the studies. Our main findings can be summarized as follows:

1) We were able to define the most frequent clinical characteristics of patients: previously healthy school-aged children, presenting with persistent fever and gastrointestinal symptoms. 2) Clinical syndromes like myocarditis and KD were present only one third of cases each one. 3) High level of care (PICU) was very frequent, although LOS was less than 1 week, and mortality was very low. 4) Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low.

Given the current hypotheses 28, 29 of the physiopathology of PIMS-TS, viral infection versus a postinfectious disease, it is important to note that RT-PCR was positive in 38% and serology in 68% of cases. An alternative hypothesis might be that these symptoms and clinical syndromes are also present in non-SARS-CoV-2 coronaviruses. For instance, there are some cases of myocarditis and KD associated with human coronavirus exposure. Thus, the clusters of PIMS-TS observed may be secondary to massive exposure to a trigger in a susceptible population, but not specifically to SARS-CoV-2. 30, 31 Most of the patients were previously healthy school-aged children. Remarkably, all patients had fever. Gastrointestinal symptoms were frequent, as well as rash and mucositis. Regards laboratory examination, all inflammatory markers were elevated, being the most consistent C-reactive protein. C-reactive protein is very unspecific, but it is disproportionally elevated, approximately 20 times the normal value. Lymphopenia was also commonly found. Cases of PIMS-TS fulfilling criteria for KD and myocarditis were not reported frequently, approximately one third of cases each one. Respiratory and neurological symptoms were usually mild, and acute kidney injury accounted for one third. There was a high number of patients with shock criteria, explaining the frequent requirement of PICU admissions. In our study, less than 50% of children with PIMS-TS had abnormal chest x-ray or CT scan.

Left ventricular dysfunction was reported in approximately half on the patients, explaining the high frequency of shock and vasoactive support requirements. Coronary abnormalities were described in one fourth of cases during the acute phase, so we cannot extrapolate our results to mid-and long-term sequelae. 32, 33 Regards treatments, most PIMS-TS patients received intravenous immunoglobulin or steroids. Surprisingly, despite the severity of cases, antiviral therapy was very uncommon. Most of the children with PIMS-TS were admitted to PICU and required invasive interventions. However, ECMO and continuous renal replacement therapy were very uncommon. Despite the severity of admission and life support requirements, the overall prognosis of PIMS-TS was good. The average PICU LOS was less than a week, and mortality is very low.

Our study has some limitations. First, there are subtle differences in diagnosis criteria (the Royal College of Paediatrics and Child Health, Centers for Disease Control and Prevention, World Health Organization) that can lead to a bias in the selection of patients in different countries and regions. No specific information was requested to authors, and case-by-case review was not done, contributing to the heterogeneity of parameters reported. Patients described in the analyzed studies were only from Europe and North America. Risk factors to develop PIMS-TS, like socioeconomic deprived or genetically susceptible children, are still not well understood, which make the behavior of the pandemic unpredictable in regions such as Latin America and Africa. Second, many small series were added to build larger cohorts. To avoid duplication of data, case reports and some small series were not included. A large cohort has more power in the analysis, but usually, some specific data are lost. Third, PIMS-TS is a new syndrome, and our understanding is still limited. Many nonepidemiological factors, like disease awareness, media, and academic pressure, and loose criteria for diagnosis may lead to overdiagnosis as pandemic develops. However, we analyzed the quality of the studies with a standardized validated tool.

In summary, PIMS-TS is an infrequent and heterogeneous disease. It can mimic some pediatric inflammatory syndromes, like KD, macrophage activation syndrome, and myocarditis, but only in one third of cases can fulfill strict criteria. Clinical characteristics are very distinctive when compared with pediatric COVID-19 infections, frequently presenting as a severe disease. Given the recent description of PIMS-TS, there are still many questions regards its physiopathology, although, with the current empirical treatment, it has a good prognosis.

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