key: cord-0785126-c8l7zas3
authors: Kondoh, Yasuhiro; Kataoka, Kensuke; Ando, Masaru; Awaya, Yukikazu; Ichikado, Kazuya; Kataoka, Mikio; Komase, Yuko; Mineshita, Masamichi; Ohno, Yasushi; Okamoto, Hiroaki; Ooki, Takashi; Tasaka, Yuri; Tomioka, Hiromi; Suda, Takafumi
title: COVID-19and Acute Exacerbation of Interstitial Lung Disease
date: 2021-06-30
journal: Respir Investig
DOI: 10.1016/j.resinv.2021.06.007
sha: 9912e8d52dfd05d9a17dc15dfdb07862a80666e3
doc_id: 785126
cord_uid: c8l7zas3

We conducted a study to examine the effect of COVID-19 on the acute exacerbation of interstitial lung disease (AE-ILD) early in the COVID-19 epidemic (January 1–April 30, 2020). An online questionnaire survey was conducted, which was completed by 134 hospitals. During this period, 854 patients with AE-ILD (including 12 cases of COVID-AE-idiopathic pulmonary fibrosis were hospitalized at 128 hospitals. In comparison, the total number of AE-ILD hospitalizations during the same period in 2019 was 894. The number of hospitalizations increased at 17 hospitals, decreased at 27, and remained the same at 88 hospitals in 2020 compared to the same period in 2019. In 2020, COVID-19-related acute exacerbations had a significantly worse prognosis than non-COVID-19-related acute exacerbations in both 30-day and 90-day mortality. Because the prognosis of AE-ILD associated with COVID-19 is extremely poor, prevention of COVID-19 is especially important for patients with ILD.

In 2020, infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a disease known as COVID-19, has had a significant impact on medical care around the world. It is known that pneumonia in COVID-19 typically presents with bilateral ground glass-like shadows and can progress to acute respiratory failure, and in some cases, to acute respiratory distress syndrome [1] . Because viral infection is a well-known trigger for acute exacerbation of interstitial lung disease (AE-ILD) [2] , COVID-19 may be expected to affect the frequency and prognosis of AE-ILD. Using an online questionnaire, we studied the frequency of AE-idiopathic pulmonary fibrosis (IPF) associated with COVID-19, and whether there was an overall increase or decrease in AE-ILD.

We conducted a study on AE-ILD early in the COVID-19 epidemic (January 1-April 30, 2020) to examine the effect of COVID-19 on the acute exacerbation of interstitial pneumonia. An online questionnaire survey was conducted with facilities accredited by the Japanese Respiratory Society (n=705). Because COVID-19 pneumonia and AE-ILD are difficult to distinguish, those who fulfilled the criteria for AE and were COVID-19-positive were diagnosed as having COVID-19-related AE-ILD. The survey was completed in July-August 2020.

J o u r n a l P r e -p r o o f

Overall, 134 hospitals completed the online survey. From January 1 to April 30, 2020, there were 854 patients with AE-ILD (including 12 with COVID-AE-IPF, Table 1 ) who were hospitalized at 128 hospitals. In comparison, the total number of AE-ILD hospitalizations from January 1 to April 30, 2019 was 894. The number of hospitalizations increased at 17 hospitals, decreased at 27, and remained the same at 88 hospitals in 2020 compared to the same period in 2019; both time frames, therefore, were considered equivalent. In 2020, COVID-19-related acute exacerbations had a significantly worse prognosis than non-COVID-19-related acute exacerbations in both 30-day and 90-day mortality (p=0.0071, p<0.0001, respectively; Table 2 ).

This study is the first report from the viewpoint of AE-ILD of COVID-19. The total number of AE-IPF cases from January to April 2020 was almost the same as the previous year.

Although the frequency of COVID-19 in cases of acute exacerbations was extremely low at 1.4%, COVID-19-related AE-IPF had a poorer prognosis than non-COVID-19-related cases.

The prevention measures for COVID-19, such as hand washing, wearing of face masks, and avoidance of the three C's (closed spaces, crowded places, close-contact settings), are believed It is noteworthy that the 90-day mortality rate for acute exacerbations with COVID-19 was 75% (9/12), which was much higher than the non-COVID-19 90-day mortality rate (Table 1 ) [4] . This is even worse than the general COVID-19 respiratory failure mortality rate [5] . These results are compatible with the results of a recent study by Drake et al., who found that patients with ILD have a higher risk of death following COVID-19 than do matched patients without ILD [6] .

There are several possible reasons for the poor prognosis of COVID-19 in ILD. Patients with ILD are presumed to have a worse prognosis than non-ILD patients because of reduced lung reserve and impaired gas exchange. In addition, increases in SARS-CoV-2 entry genes, such as angiotensin-converting enzyme-2 and baseline changes in interleukin-6 and type 1 interferon response genes in the cells of ILD patients, have been reported [7] ; these could explain the poorer J o u r n a l P r e -p r o o f survival with COVID-19 related AE-ILD than with non-COVID-19 related AE-ILD. Finally, patients with ILD, especially IPF, have high levels of αvβ6 integrin in the alveolar epithelium, which is associated with a poor prognosis [8] ; αvβ6 integrin also includes a binding site for the SARS-CoV-2 virus [9] . These findings can explain the poorer prognosis of COVID-19-related AE-ILD.

The 30-and 90-day mortality of AE-ILD in this study were much lower (15% and 16%, respectively) than the reported mortalities in previous studies, which ranged from 33%-83% [10] [11] [12] .

We are not sure of the reasons for this, but early detection and recently improved management, such as high-flow nasal cannula oxygen therapy, non-invasive ventilation, and pharmacologic therapy, including antifibrotics, may have improved the outcomes [13] . In fact, recent clinical trials reported various lower mortality rates of AE-IPF: 7.1% and 61.2% in the INPULSIS ® trials, 10.8% and 27.5% in a randomized controlled trial of thrombomodulin for AE-IPF [14, 15] . This study has several limitations. First, because the survey was conducted through a retrospective, online-based survey, the results may have been affected by the personal bias of the survey participants. Second, this study was conducted in a single country (Japan) during a specific 

In conclusion, the total number of AE-IPF cases was similar before and after the start of the COVID-19 pandemic. Because the prognosis of AE-IPF associated with COVID-19 is extremely poor despite the low frequency of occurrence, prevention of COVID-19 is especially important for ILD patients. 

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

Acute exacerbation of idiopathic pulmonary fibrosis. An international working group report

Viral infection in acute exacerbation of idiopathic pulmonary fibrosis

Acute exacerbations of fibrotic interstitial lung diseases

Dexamethasone in hospitalized patients with Covid-19 -Preliminary report

Outcome of hospitalization for COVID-19 in patients with interstitial lung disease. An international multicenter study

Single-cell RNA-sequencing reveals dysregulation of molecular programs associated with SARS-CoV-2 severity and outcomes in patients with chronic lung disease

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease

A potential role for integrins in host cell entry by SARS-CoV-2

Acute exacerbation of idiopathic pulmonary fibrosis: a systematic review

Acute exacerbations of progressive-fibrosing interstitial lung diseases

Acute exacerbations of fibrotic interstitial lung diseases

Recent lessons learned in the management of acute exacerbation of idiopathic pulmonary fibrosis

Differing severities of acute exacerbations of idiopathic pulmonary fibrosis (IPF): insights from the INPULSIS trials

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