key: cord-0784640-makjahcd authors: Roa, Dante; Moyses, Harry; Leon, Stephanie; Hamrick, Barbara; Sarria, Gustavo R.; Li, Benjamin; Tajima, Toshiki; Necas, Ales; Guzman, Carmen; Paucar, Oliver; Gonzales, Alberto; Challco, Roger; Montoya, Modesto; Arqque, Zintia; Gonzales, Andres; Hernandez, Jimmy; Drake, Johnny; Villane, Ron; Lea, Jon title: Dose simulations of an early 20th century kilovoltage pneumonia radiotherapy technique performed with a modern fluoroscope date: 2020-09-18 journal: Med Dosim DOI: 10.1016/j.meddos.2020.08.002 sha: 3f88e300d086d91dc30606e5cf49963b17cf8191 doc_id: 784640 cord_uid: makjahcd To simulate an early 20th century viral pneumonia radiotherapy treatment using modern fluoroscopy and evaluated it according to current dose guidelines. Monte Carlo was used to assess the dose distribution on an anthropomorphic phantom. Critical organs were: skin, breasts, esophagus, ribs, vertebrae, heart, thymus, and spinal cord. A 100 kV(p) beam with 3 mm Al HVL, 25 × 25 cm(2) posterior-anterior (PA) field and 50 cm source-to-surface distance were simulated. Simulations had a resolution of 0.4 × 0.4 × 0.06 cm(3) and a 6% uncertainty. Hundred percent dose was normalized to the skin surface and results were displayed in axial, coronal, and sagittal planes. Dose volume histograms were generated in MATLAB for further analysis. Prescription doses of 0.3, 0.5, and 1.0 Gy were applied to the 15% isodose for organ-dose comparison to current tolerances and potential risk of detriment. Ninety-five and ninety-seven percent of the right and left lung volumes, respectively, were well-covered by the 15% isodose line. For the 0.3, 0.5, and 1.0 Gy prescriptions, the maximum skin doses were 2.9, 4.8, and 9.6 Gy compared to a 2.0 Gy transient erythema dose threshold; left/right lung maximum doses were 1.44/1.46, 2.4/2.4, and 4.8/4.9 Gy compared to a 6.5 Gy pneumonitis and 30 Gy fibrosis thresholds; maximum heart doses were 0.5, 0.9, and 1.8 Gy compared to the 0.5 Gy ICRP-recommendation; maximum spinal cord doses were 1.4, 2.3, and 4.6 Gy compared to 7.0 Gy single fraction dose threshold. Maximum doses to other critical organs were below modern dose thresholds. A 100 kV(p) PA field could deliver a 0.3 Gy or 0.5 Gy dose without risk of complications. However, a 1.0 Gy dose treatment could be problematic. Critical organ doses could be further reduced if more than one treatment field is used. In the early 20th century, viral and bacterial pneumonia patients were treated with radiotherapy to deliver lung doses of 0.3 to 1.0 Gy using 100 to 200 kV p x-ray beams. [1] [2] [3] [4] [5] This was a https://doi.org/10.1016/j.meddos.2020.08.002 0958-3947/© 2020 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved. JID: MDO [mUS5Gb; September 18, 2020; 8:45 ] one-time treatment and signs of recovery appeared as early as 3 to 5 hours after irradiation. Animal experiments of the time demonstrated that low radiation doses upregulated lymphocytosis and reduced inflammation. 1 , 6 , 7 Today, modern studies support these conclusions. 8 , 9 Unfortunately, radiotherapy treatments stopped in the 1940s with the advent of antibiotic-and steroid-therapies despite their high cure rate. 1 In light of the COVID-19 pandemic, there has been renewed interest in using low-dose radiotherapy as a treatment option for infected patients in critical condition, and when other treatments have failed to produce a cure. [1] [2] [3] Radiotherapy linear accelerators are the most effective technology for delivering such a treatment; however, the risk of infection to staff and cancer patients, as well as contamination of a radiation oncology clinic can be high despite rigorous procedure protocols. Modern fluoroscopes could be an alternative to deliver therapeutic radiation doses to the lungs using x-ray energies similar to those used historically. Fluoroscopes are more widely available worldwide than radiotherapy linear accelerators and could be used in intensive care units (ICUs) or emergency rooms (ERs) eliminating the need of patient transportation to a radiation oncology clinic. It is worth exploring the dosimetry that a historical pneumonia treatment could have achieved via computer simulations using a modern kV x-ray beam from a fluoroscope on an anthropomorphic phantom. The simulations could justify an experimental verification with modern fluoroscopes and prove (or disprove) that they could be effective in delivering a low-dose radiotherapy treatment, since there are no modern data available and the field of dosimetry was not developed enough in the early 20th century to have historical data. Prescription dose 1-7 and technical information 10-12 , 15 , 17 , 18 can be extracted from published clinical and historical reports and used in the simulations. In this study, prescription doses of 0.3, 0.5, and 1.0 Gy were used for isodose normalization while dose distributions and maximum doses to critical organs were evaluated according to modern dose tolerance guidelines. Results from this work and potential implementation using modern fluoroscopes are presented. The Monte Carlo (MC) code PENELOPE with its mathematical anthropomorphic phantom was used for simulations. 13 The phantom was an adult female anatomy that included most organs ( Figs. 1 a and 1 b) with published density information for each of them. Each lung was 24 cm superior-inferior, 12 cm left-right, and 10 cm anterior-posterior. Organs-at-risk were: skin, breasts, ribs, esophagus, vertebrae, heart, thymus, and spinal cord. Skin volume was limited to the thoracic region only. The SPEKTR 3.0 14 code was used to generate a 100 kV p x-ray beam spectrum from a tungsten target with an aluminum filter. Historically, a single-or 3-phase generator 11 would have produced significant ripple and a lower effective ener gy than a modern beam; however, 100 kV p is at the bottom of the cited energy range, so the effective ener gy should still be appropriate for the historical context. A report of that time recommends the use of a 3-mm Al filter for x-ray radiotherapy of the lungs, 15 which would result in a half-value layer (HVL) of approximately 3 mm Al, assuming an inherent tube filtration similar to modern tubes and tube ripple appropriate for a 3-phase generator. 1 Thus, a 3-mm Al HVL was selected for the simulated beam, which is a slightly softer spectrum than on modern units. 16 The simulated treatment consisted of a 25 × 25 cm 2 posterior-anterior (PA) field at 50 cm source-to-surface distance (SSD) ( Fig. 1 c) . The field covered both lungs and could have been defined with an x-ray system of that time ( Fig. 1 d) which was used for radiography, fluoroscopy, and radiotherapy procedures. 10-12 , 15 , 17 , 18 The simulations had a spatial resolution of 0.4 × 0.4 × 0.06 cm 3 and an uncertainty of 6% for 2 × 10 9 histories. Cumulative dose volume histograms (DVHs) were generated in MATLAB (MathWorks, Natick, MA) and the MATLAB DVH code was validated using a known data set prior to the actual data analysis. DVHs were generated for the left/right lungs, skin, left/right breasts, esophagus, ribs, vertebrae, heart, thymus, and spinal cord. The skin surface dose was normalized to 100% and considered the reference dose calibration location. For the absolute dose analysis, the 15% isodose line was normalized to a 0.3, 0.5, and 1.0 Gy prescription dose, respectively, to obtain absolute dose information. These doses were selected based on the historical treatment doses reported. [1] [2] [3] [4] [5] Mean and maximum relative doses for each organ-at-risk were extracted from the DVHs, normalized to each prescription dose, and evaluated against the International Commission on Radiological Protection (ICRP) and other reports for organ dose tolerance assessment. [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] Results Figure 2 a shows the percent depth dose at the phantom's central sagittal plane. Peak doses at 0.5, 3.0, 5.5, and 19.5 cm depths corresponding to ribs or vertebrae regions resulted from photoelectric interactions. The most prominent peak was in the ribs at 0.5 cm depth with a 325% maximum point dose. The second-most prominent was in the vertebrae at 3 cm depth with 225% maximum dose. Conversely, soft tissue regions showed a smooth dose deposition reduction as a function of depth. Figures 2b-2d show axial, coronal, and sagittal isodoses. The 15% isodose provided coverage to both lungs with 95% and 97% of the right and left lung volumes covered as shown in the DVH ( Fig. 3 a) . The maximum relative doses to the lungs were 72% (right) and 73% (left). Table 1 shows mean and maximum relative and absolute doses for the lungs, skin, breasts, esophagus, ribs, vertebrae, heart, thymus, and spinal cord, after applying a 0.3, 0.5, and 1.0 Gy prescription dose normalization to the 15% isodose. Table 1 also includes dose tolerances provided by ICRP and other reports for evaluation. The maximum dose to the skin exceeded 2.0 Gy 19-21 (the transient erythema dose threshold) by 44%, 240%, and 480% for the 0.3, 0.5, and 1.0 Gy prescriptions, respectively. The heart maximum dose exceeded 0.5 Gy (the threshold for potential cardiovascular and blood circulatory effects) by 5%, 76%, and 352% for the 0.3, 0.5, and 1.0 Gy prescriptions, respectively. 19 , 21 , 22 The heart mean dose also exceeded this threshold by 42% for the 1.0 Gy prescription, while it remained below the threshold for the 0.3 Gy and 0.5 Gy prescriptions. Maximum doses to the lungs did not pose any risk for pneumonitis (6.5 Gy threshold for acute exposure) 19 , 17 or fibrosis (30.0 Gy threshold) 23 for any prescription dose. The lung mean doses suggested that a prescription dose normalization to the 20% instead of the 15% isodose could have been used which would have resulted in lower doses to critical organs. Mean and maximum doses to the breast were below the proposed 1.0 Gy dose threshold at which the risk for developing secondary cancers increases in women younger than 40 years. 24 Ribs maximum doses (prescription dose) were 78% (0.3 Gy), 64% (0.5 Gy), and 28% (1.0 Gy) below the 30.0 Gy single-fraction dose threshold. Furthermore, the dose to 1 cm 3 of the ribs' volume, for all prescriptions, was below the 22.0 Gy single-fraction dose threshold. 27 , 28 The vertebrae maximum doses (prescription dose) were 67% (0.3 Gy) and 45% (0.5 Gy) below, but 11% (1.0 Gy) above the 12.4 Gy single-fraction dose threshold. 27 , 28 Ribs and vertebrae maximum doses for all prescriptions far exceeded the ICRP 118 recommended limit of 2.0 Gy dose per fraction but not the cumulative dose limit of 50.0 Gy. 19 Mean and maximum doses to other critical organs for all prescription doses were well within modern dose tolerances. Calabrese et al. 1 were the first to suggest re-visiting the role of radiotherapy to treat pneumonia, and now, this suggestion has a newfound relevance in light of the COVID-19 pandemic. The early radiotherapy treatments used 100 to 200 kV p x-rays to deliver a 0.3 to 1.0 Gy single fraction treatments. These x-ray energies are comparable to those produced with modern fluoroscopes. Although fluoroscopes are intended for imaging, it could be possible for them to be used for treatment purposes in these extraordinary times. If the image receptor was covered with lead to drive the exposure rate to its maximum, treatment times to deliver a 0.3 Gy prescription dose to patient of comparable size as the simulated phantom could be 15 to 20 minutes with a mobile fluoroscope and 2 to 3 minutes with an interventional fluoroscope operating in digital acquisition (cine) mode. Specific treatment times would have to be determined based on the exposure rate of the fluoroscope being used, with longer treatments potentially broken up to allow for periods of tube cooling, if this becomes a concern. This investigative dosimetric analysis provides quantitative information on dose distributions and detriments to organs from such radiation treatments and suggests a potential treatment delivery with bedside c-arm fluoroscopes in an inpatient setting. For a simple treatment setup consisting of a PA field, the 15% isodose provided effective coverage to the lungs with 95% and 97% of the right and left lung volumes covered. After applying a 0.3, 0.5, or 1.0 Gy prescription dose to the 15% isodose, the maximum dose to the lungs did not exceed modern thresholds for pneumonitis or fibrosis. 19 , 23 However, it could have exacerbated preradiation fibrosis caused by the pneumonia and/or affected patients with borderline interstitial fibrosis. 20 It is likely that for the 0.3 and 0.5 Gy prescriptions, detrimental skin effects would not be permanent, but that may not be the case for a 1.0 Gy dose. The 0.5 and 1.0 Gy prescriptions had maximum doses to the heart that significantly exceeded the 0.5 Gy dose threshold for possible cardiovascular and blood circulatory effects according to the ICRP 118 report. 19 The ICRP 120 report 21 remains at this threshold. Other studies suggest that the risk of radiation-related heart disease from a low-dose radiotherapy can begin to manifest at 3.0 to 4.0 Gy. 22 It is possible that a maximum heart dose of 0.9 Gy (0.5 Gy prescription) or 1.8 Gy (1.0 Gy prescription) could cause microvascular damage to the myocardium; however, the risk for heart-related complications would be low. Furthermore, peak skin doses from modern interventional cardiac procedures routinely exceed 2.0 to 3.0 Gy, 29 which implies that cardiac doses over 0.5 Gy are frequent and not an impediment to treatment. The 0.3 Gy prescription did not exceed this limit. Maximum doses to the ribs and vertebrae for all prescriptions were below dose thresholds for a single fraction treatment. 27 , 28 However, they far exceeded ( ≥200%) the recommended ICRP 118 fractionated dose of 2.0 Gy. 19 Although the risk of radionecrosis, rib fracture, and/or musculoskeletal atrophy would be low, no additional treatments without risk of complications would be possible with this setup. Additional treatment fields, such as anteriorposterior (AP) or laterals, could reduce maximum doses to these structures, but not below 2.0 Gy at the higher prescribed doses. Published reports indicate that women under the age of 40 could have a 2.5-fold greater risk of secondary cancers if exposed to a dose greater than 1.0 Gy, compared to no risk for older women 10 years after irradiation. 24 In this work, mean doses to the breasts were below this level suggesting little-to-no detrimental effects. Maximum doses to the spinal cord, esophagus, and thymus were within modern dose tolerances and did not pose risk of future detriment. 19 , 25-28 This study indicates that a radiotherapy pneumonia treatment with a single PA field and a 0.3 or 0.5 Gy prescription dose to both lungs would have a low probability of radiation-induced detriment to critical organs. However, a 1.0 Gy dose treatment might be problematic. Treatment setups employing more fields could result in a more homogeneous dose distribution to the lungs, and lower dose to critical organs; this is an area of future work. Treatment setups with 2 or more fields and hardened beams are possible with modern fluoroscopes. Fixed interventional c-arms could be ideal due to their large, highly filtered x-ray beams, higher x-ray tube heat capacities, and ease of positioning. Mobile c-arms could also be used for this purpose, albeit with longer treatment times but with the convenience of an in-situ treatment delivery. Modern mobile fluoroscopes do not have field sizes as large as those simulated; however, therapy covering the entire lung field is possible with multiple beam angles. A modified fluoroscopy unit with a larger field size might be possible with manufacturer support. While such a system may not be legally used for imaging in the United States, it could potentially be used as an investigational device under IRB approval. Perhaps another option could be the use of existing fluoroscopes on targeted treatments to affected areas identified on CT. 30 The prospect of rapid, inexpensive, and noninvasive therapy to reduce or prevent ventilator requirements could be paradigmchanging for centers with limited ventilator supplies. Clinical trials to evaluate the efficacy of low-dose radiation with linear accelerators for COVID-19 patients are underway in India, Iran, Italy, Spain, and the United States. However, there are no trials exploring the use of a fluoroscope-based delivery. Low-dose treatments (0.3 to 0.5 Gy) via mobile c-arm fluoroscope in situ ( e.g. , at the patient bedside in intensive care units or emergency rooms) could prevent viral spread, contamination of radiotherapy clinics and other hospital spaces, and could be cost effective. The benefit-to-risk ratio is especially high for the elderly patients, who are more susceptible to complications from COVID-19 and less likely to develop radiation-induced cancers. 31 Whereas the radiobiologic response remains to be explored further in COVID-19 pneumonia, 32 the implementation of a safe, illness-reducing therapy delivered with fluoroscopy technology could be immediately implemented. Patients in low-to middle-income countries could have access to a viable life-saving treatment until a more definitive cure becomes available. This study suggests that radiotherapy using a 100 kV p x-ray source could be used to deliver a 0.3 or 0.5 Gy prescription dose to the lungs, with negligible risk of pneumonitis or fibrosis. Maximum dose to the skin could cause transient erythema that resolves over time. A 1.0 Gy prescription dose, however, may result in more serious or long-term complications unless additional treatment fields are employed to reduce the maximum doses to critical organs. JID: MDO [mUS5Gb How radiotherapy was historically used to treat pneumonia: could it be useful today? Is low dose radiation therapy a potential treatment for COVID-19 pneumonia? 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A concise presentation of preliminary data Personal view: low-dose lung radiotherapy for COVID-19 pneumonia-the atypical science and the unknown collateral consequence The authors would like to thank Professor Mauro Valente of the University of Cordoba, Argentina for his support with the Monte Carlo simulations.No financial support was received for this project. The authors declare no conflicts of interest.