key: cord-0784418-gosr78zc
authors: Lo Monaco, MariaRita; Di Giambenedetto, Simona; Martone, Anna Maria; De Gaetano Donati, Katleen; Landi, Francesco
title: Encephalopathy as neurological involvement of SARS-COV-2 infection
date: 2020-06-26
journal: Clin Infect Pract
DOI: 10.1016/j.clinpr.2020.100034
sha: a2ad02c61a5b8ef46ed5289368e737d850b2cc91
doc_id: 784418
cord_uid: gosr78zc

nan

U N C O R R E C T E D P R O O F 1

The most important characteristic symptom of patients with SARS- This is another description of SARS-CoV-2 SNC involvement [2] [3] [4] .

The infection of SARS-CoV has been previously reported in the brains 54 of both patients and experimental animals [5] . The exact way by 55 which SARS-CoV can enter the central nervous system is not clearly 56 demonstrated. Some evidence shows that coronavirus may first enter 57 peripheral nerve terminals, and then they can enter the central nervous 58 system via a synapse-connected pathway [6] . This trans-synaptic trans-59 fer has been well recognized for other coronaviruses, such as influenza 60 [7] . Considering the similarity between SARS-CoV and SARS-CoV2, it is 61 reasonable that SARS-CoV-2 also has similar potential. However, the de-62 scription of this case provides evidence of invasion of the brain by the 63 coronavirus also through the olfactory pathway rather than via periph-64 eral nerves.

Neurological manifestations of 67 hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series 68 study

Sars-Cov-2: underestimated damage to nervous

Neurological complications of coronavirus disease 75 (COVID-19): encephalopathy. Cureus

Clinical features of patients infected 81 with 2019 novel coronavirus in Wuhan

The vagus nerve is one route of transneural inva-84

E-mail address: mariarita.lomonaco@policlinicogemelli.it

Gemelli Against COVID-19 Geriatric Team

CLINPR-100034

Published by Elsevier Ltd on behalf of British Infection Association

Encephalopathy as neurological involvement of SARS-COV-2 infection