key: cord-0780777-yu01hb1m
authors: Jung, Jaehun; Jang, Hanaram; Kim, Hye Kyung; Kim, Jieun; Kim, Arim; Ko, Kwang-Pil
title: The Importance of Mandatory COVID-19 Diagnostic Testing Prior to Release from Quarantine
date: 2020-08-20
journal: J Korean Med Sci
DOI: 10.3346/jkms.2020.35.e314
sha: 58c61dca02595188b5cb7e1bd11a94621e5345fb
doc_id: 780777
cord_uid: yu01hb1m

A 14-day quarantine is implemented in many countries in response to the coronavirus disease pandemic. Korea implemented a mandatory quarantine for those who had close contact with infected patients and those returning from abroad. The present study explored the implications of mandatory coronavirus disease 2019 testing before releasing individuals from the 14-day quarantine in Incheon, Korea. From February 11 to July 5, 2020, 19,296 people were self-quarantined, and 56 (0.3%) of them were confirmed cases of COVID-19. Twenty (35.7%) were identified through the reporting of symptoms during quarantine, and 32 (57.1%) were identified using mandatory pre-release RT-PCR tests. Among the 32, 14 (25%) individuals reported mild symptoms and 18 (32.1%) were asymptomatic. It is suggested that mandatory diagnostic testing prior to release and the symptom-based surveillance after the 14-day quarantine may help control delayed or asymptomatic COVID-19 cases.

using cell phone applications, telephone interviews, and self-reports. Field epidemiologists conducted in-depth epidemiological investigations regarding the presence and onset of symptoms, contact tracing, and diagnostic testing on family members in the households of individuals who tested positive on the pre-release test. In addition, local health authorities operated a symptom-based surveillance system after quarantine release.

From February 11, 2020 to July 5, 2020, 19,296 people were self-quarantined in Incheon. Among them, there were 56 (0.3%) confirmed cases of COVID-19. Twenty (35.7%) were identified through the reporting of symptoms during quarantine, and thirty-two (57.1%) were identified using mandatory pre-release RT-PCR tests. Until confirmation, none of the 32 individuals reported symptoms.

A retrospective epidemiologic investigation revealed that 14 (25%) individuals reported mild symptoms and 18 (32.1%) were asymptomatic. In addition, two (3.6%) individuals tested negative and were asymptomatic before release, but subsequently reported symptoms or tested positive ( Table 1) . The delayed cases caused infection in their families, with four additional confirmed cases being found. The remaining two (3.6%) individuals tested positive during quarantine due to exposure to confirmed cases within their families (Fig. 1) .

This study found that over half of COVID-19 individuals diagnosed during or after quarantine exhibited no symptoms. The 14-day quarantine period was based on the maximum incubation period of SARS-CoV-2. 4 However, several studies have found outliers with a maximum incubation period of 19 days. 5 This study shows that there are some outliers with incubation periods that exceed the 14-day quarantine period. In addition, asymptomatic infections hinder the identification of these cases without active diagnostic testing.

Incheon, which accounts for 7% of the country's population, was the only city in Korea that conducted mandatory diagnostic testing as a condition for quarantine release.

A limitation of this study is that we do not have detailed information on the of basic characteristics and clinical features of the individuals with confirmed COVID-19, or the location where testing was performed. The incidence of COVID-19 in Korea is currently relatively low, so these findings may not apply to other countries or settings where the risk of exposure differs from that in Incheon.

The present study shows that a significant number of cases may occur after the 14-day quarantine period ends, and suggests that mandatory diagnostic testing prior to release may help control delayed or asymptomatic COVID-19 cases. It also suggests the necessity of operating symptom-based surveillance even after the 14-day quarantine is over.

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The study protocol was approved by the Institutional Review Board of the Gil Medical Center, Gachon University College of Medicine (GFIRB2020-284). Informed consent was waived by the board.