key: cord-0780120-415eod1f authors: Yazer, Mark H.; Jackson, Bryon; Pagano, Monica; Rahimi‐Levene, Naomi; Peer, Victoria; Bueno, José Luis; Jackson, Ryan P.; Shan, Hua; Amorim‐Filho, Luiz; Lopes, Maria‐Esther; Boquimpani, Carla; Sprogøe, Ulrik; Bruun, Mie Topholm; Titlestad, Kjell; Rushford, Kylie; Wood, Erica M.; McQuilten, Zoe K.; de Angelis, Vincenzo; Delle Donne, Michela; Murphy, Mike; Staves, Julie; Cho, Duck; Nakamura, Fumihiko; Hangaishi, Akira; Callum, Jeannie; Lin, Yulia; Mogaddam, Mostafa; Gharehbaghian, Ahmad; Lozano, Miquel title: Vox Sanguinis International Forum on Hospital Transfusion Services' Response to COVID‐19 date: 2020-05-08 journal: Vox Sang DOI: 10.1111/vox.12943 sha: 55bfdd1074ce1eae3b1b5733e059980d4856ef48 doc_id: 780120 cord_uid: 415eod1f The novel coronavirus (SARS‐Cov‐2) that was first reported in Wuhan, China and provokes the COVID‐19 disease has developed into a pandemic with hundreds of thousands of people infected. Many governments have enforced social isolation protocols on their citizens, which has led to the closure of many large public gatherings in order to limit the spread of the virus. These closures could reasonably be expected to affect blood collections, thereby presaging shortages of blood for transfusion. On the other hand, steps such as the postponement of elective surgeries and other non‐urgent transfusions could mitigate against potential shortfalls in the blood supply. The novel coronavirus (SARS-Cov-2) that was first reported in Wuhan, China and provokes the COVID-19 disease has developed into a pandemic with hundreds of thousands of people infected. Many This article is protected by copyright. All rights reserved governments have enforced social isolation protocols on their citizens, which has led to the closure of many large public gatherings in order to limit the spread of the virus. These closures could reasonably be expected to affect blood collections, thereby presaging shortages of blood for transfusion. On the other hand, steps such as the postponement of elective surgeries and other non-urgent transfusions could mitigate against potential shortfalls in the blood supply. [1] The transfusion community has faced epidemics and pandemics before,[2-9] but little has been published about the preparations made by hospital-based transfusion services for handling samples and performing pretransfusion testing on patients who are affected by the disease. A study of the policies and procedures vis-à-vis pre-transfusion testing and the provision of blood products at three Japanese hospitals during the recent Ebola epidemic revealed different approaches to performing pre-transfusion testing on potential recipients and how the blood products were issued. [10] Given the urgent need to develop best practices for conducting pre-transfusion testing and issuing blood products not just during the current novel coronavirus pandemic but also for future pandemics, the time is now propitious to understand how transfusion services in cities with different burdens of this disease are approaching these issues and for the dissemination of different policies and procedures that facilitate the timely provision of blood products to our patients while maintaining a high level of safety for transfusion service staff. Responses were received from a total of 12 centers from around the world including Australia, Brazil, Canada, Denmark, Iran, Israel, Italy, Japan, Korea, Spain, UK, and USA. Table 1 demonstrates the demographics of the respondents and the cities in which their institutions were located. All respondents worked in large academic medical centers, although the Brazilian respondent worked at a hospital that only treated hematology oncology patients and the Iranian respondent worked in a private specialty hospital. At the time of survey completion, the absolute number of confirmed coronavirus cases ranged This article is protected by copyright. All rights reserved from a low of 4,831 (Israel) to a high of 386,817 (USA), but accounting for the population of each country, the rate of confirmed cases ranged from 0.01% (Brazil and Japan) to 0.30% (Italy). The rate of coronavirus infections was felt to be increasing in Israel, USA, Canada, Japan, and Brazil, stable in the UK, and Korea, and decreasing in Spain, Denmark, Australia, and Italy. However, the survey responses were received between 31 March, 2020 and 24 April, 2020, so the number of confirmed cases and the respondent's opinion as to the extent of the spread of coronavirus throughout their country reflected the state of the disease at the time the survey was completed; this number and opinion might have changed in the time between survey completion and the publication of this International Forum. All of the respondents indicated that their transfusion services accepted samples from patients with confirmed or suspected coronavirus infections. The American, Australian, Iranian, and Japanese respondents indicated that they did not make any changes to the processes of sample procurement and labeling, accepting the sample in the transfusion service, testing, storing, or discarding the sample. For the centers that did institute new policy changes for handling these samples, the Israeli and Korean respondents indicated that the sample label had the word COVID written on it to alert the technologists to implement the enhanced safety measures for handling and testing these samples, and the samples were transported to the transfusion service in clear plastic bags. The Italian respondent indicated that the labeling was performed outside of the patient's room in a designated safe area. The Spanish respondent indicated all samples that were received at the transfusion service for pretransfusion testing were assumed to be potentially contaminated with coronavirus and so they were all cleaned with hypochlorite before being processed, and they were also UV irradiated for 30 minutes. Similarly, the Danish respondent indicated that samples from coronavirus patients were cleaned by the phlebotomist before they arrived at the transfusion service. Interestingly, the Italian respondent indicated This article is protected by copyright. All rights reserved that paper requisitions were sealed in plastic bags for 5 days to sanitize them before being archived. At the Brazilian and Canadian respondents' sites, all samples regardless of the presence of coronavirus were opened behind a plastic shield, while in a similar vein, at the UK respondent's site, the sample tubes were left for a while to settle after centrifugation so as to reduce the probability of aerosolizing the contents. Also, at the Canadian site, all laboratory staff wore face masks as maintaining appropriate physical distancing is not always possible. All of the respondents indicated that the samples were tested in the usual location in the transfusion service except for the Israeli respondent who indicated that pre-transfusion testing was performed in a biosafety cabinet and the Korean respondent who indicated that the samples were tested in a fume hood. In terms of the personal protective equipment (PPE) that was worn by the transfusion service technologists, the Spanish, American, Brazilian, Danish, Australian, and British respondents indicated that the standard laboratory PPE was worn when testing these samples. The Israeli respondent indicated that double gloves, goggles, an N95 respirator, and a gown was worn when testing samples from known or suspected coronavirus patients, while the Italian respondent indicated that a mask was added to the standard PPE when testing such a sample. At the Korean respondent's transfusion service, gloves, goggles, and a surgical mask were worn when testing these samples. Once the pre-transfusion testing had been completed, most of the respondents stored these samples in their routine manner, expect at the Israeli respondent's laboratory where the samples were stored in a separate shelf in a sealed container, and at the Italian respondent's laboratory where the samples from known or suspected coronavirus patients were kept in a dedicated rack in the same refrigerator as the other samples. The Korean respondent indicated that the samples were returned to the plastic bag into which they were received for storage, and when it was time to dispose of the samples they were sent to their department of microbiology for disinfection and disposal. All of the other respondents indicated that the samples were discarded following their routine protocol. Lastly, as stated above, all of the respondents indicated that their transfusion services accepted samples from known or suspected coronavirus patients. However, the Israeli respondent indicated that This article is protected by copyright. All rights reserved prior to receiving the biosafety cabinet, samples from these patients were not accepted for pre-transfusion testing. Instead, group O RBCs and group AB plasma would have been issued to these patients. All of the patient's available transfusion and immunohematological history was reviewed prior to issuing blood products, and antigen negative RBCs would have been issued to an alloimmunized recipient. Uncrossmatched RBCs were rarely required in this setting as the biosafety cabinet was available quickly after the need for it arose. Question 3: If a cooler (i.e., a temperature controlled device used for storing blood products outside of the blood bank) of blood products was issued on such a patient how did the transfusion service handle the cooler? The American respondent indicated that blood products were loaded into the cooler in the routine manner for patients with known or suspected coronavirus, while the Australian respondent indicated that RBCs were individually put into bags and then loaded into the cooler. These coolers always remained outside of the patient's room, thus the cooler did not need to be decontaminated upon its return to the transfusion service. RBCs that were taken into a patient with known or suspected coronavirus' room but not transfused were discarded if they were returned to the blood bank. The Canadian respondent also issued RBCs in individual plastic bags that had been sealed to indicate if the bag had been opened; at this center, coolers were decontaminated upon return to the transfusion service, which had been the routine practice before this pandemic, and any RBCs that were returned in unopened plastic bags were returned to the inventory; RBCs that were returned in opened bags were discarded. The Australian and Canadian policy of issuing RBCs in individual plastic bags in a cooler were new policies that were implemented during this pandemic. The American and Italian respondents indicated that RBCs that were returned in a cooler were wiped down and restocked. The Canadian, American, and Brazilian respondents indicated that the coolers were also disinfected, with the latter indicating that this was a new policy that had been implemented during this pandemic and that it would become permanently adopted. This article is protected by copyright. All rights reserved The Spanish and British respondents indicated that they did not make any changes to their cooler issuing policy, while the Israeli, Danish, Italian, and Korean respondents indicated that they do not routinely issue coolers to any patient. Question 4: Does your facility have an existing plan to deal with samples from patients with novel pathogens? Many of the respondents indicated that they had a pre-existing plan for handling samples from patients with novel pathogens. For example, the Israeli plan was derived from their experience with the 2003 SARS outbreak, the Korean respondent's plan was based on their experience with the MERS outbreak, and the Canadian respondent's plan was based on the Ebola virus outbreak. The Spanish respondent indicated that the hospital had a plan but that it had been dormant before it was reactivated for this pandemic, while the Danish respondent indicated that their pre-existing plan was designed for patients who were contaminated with radiation, chemical or biological agents. Both the American and Italian respondents indicated that they did not have a specific plan for dealing with novel pathogens because standard universal precautions were always being used for all samples. Both the Brazilian and the British respondents indicated that their hospitals did not have a pre-existing plan. This article is protected by copyright. All rights reserved Question 6: How has the utilization of red blood cells, platelets and plasma in your hospital changed since the start of the pandemic? Only the Australian and Korean respondents indicated that the use of RBCs, plasma, and platelets were unchanged from pre-pandemic levels. The other respondents indicated that they had either quantitatively or qualitatively noticed reductions in transfusions at their centers of around 30% for RBCs, 20-47% for platelets, and about 40% for plasma. Not surprisingly, the Brazilian respondent whose hospital exclusively treats hematology oncology patients reported no change in platelet transfusions thus far in the pandemic. The Israeli, Spanish, Danish, British, and Korean respondents did not expect a blood shortage as a result of this pandemic. Others, such as the Brazilian, Italian and Iranian respondents, expected shortages in the short, medium, and long terms, while the American, Australian, Canadian, and Japanese respondents expected medium term shortages. The Canadian respondent also expects a shortage of plasma fractionation products such as IvIg in the long term. In terms of shortage mitigation strategies, many respondents such as the Israeli, Australian, and Italian respondents indicated that their hospitals had cancelled elective surgeries thereby helping to preserve their blood product inventories. Others, such as the respondents from USA, Brazil, Australia, and Canada held information campaigns to remind clinicians about appropriate transfusion thresholds and transfusing a single RBC unit at a time. The Canadian respondent also indicated that they reminded their clinicians about the appropriate use of pharmaceuticals such as prothrombin complex concentrates, tranexamic acid, and intravenous iron. The British respondent indicated that they reduced their hospital's blood inventory level by about 30% to reduce wastage. This article is protected by copyright. All rights reserved See the individual responses for more details. In general, the advice from the respondents was to plan ahead of time for how the transfusion service should respond when these events happen. The Spanish and Canadian respondents mentioned their lack of advance preparedness for implementing a convalescent plasma program, while the Brazilian respondents advised having a plan for employee travel to and from the hospital when public transport is unavailable and for dealing with reduced staffing due to illness. The Italian respondent was concerned about having too many people donate blood early in the pandemic when the need for products was low thereby potentially creating waste and making donors ineligible to donate as the pandemic wanes and demand returns to normal. The British respondent suggested keeping the workflow as routine as possible to avoid confusion and errors. The Spanish, Canadian, and British respondents indicated that CP will be available in the context of a clinical trial; the multicenter Spanish trial will randomize 278 patients into either the standard of care or standard of care plus CP arms, and primarily use clinical outcomes such as if the patient needs hospitalization and if any supplemental oxygen is required. Patients in the CP arm will receive one unit that will be between 250-300 ml collected by any approved apheresis machine, and the plasma will undergo pathogen inactivation using any approved method. Details of the Canadian and British trials are provided in the response section. The American respondent also plans to offer CP in the context of a clinical trial an also for compassionate use without pathogen inactivation. The Israeli and Brazilian respondents indicated that the Intercept (Cerus) technology will be used for their CP, while the respondents in Denmark, USA, and the UK indicated that the CP will not undergo pathogen inactivation. At the time of survey completion, CP was not available in Australia, Korea, and Japan. Among countries with different levels of people affected by the SAR-Cov 2 pandemic, the hospital blood banks/transfusion departments have reacted differently to the pandemic. A third of the respondents did This article is protected by copyright. All rights reserved not change their policies/procedures for samples received from known or suspected patients while the remainder changed their practice in some way to minimize the exposure to potential contaminated specimens. Interestingly 75% of the respondents reported a decrease in overall blood components utilization due to the changes introduced at the hospitals to treat the COVID-19 patients. Convalescent plasma is also being considered or used in 75% of the responding centers to treat COVID-19 patients. Potential impact of pandemic influenza on blood safety and availability Ebola and blood transfusion: existing challenges and emerging opportunities Impact on blood safety of the last arboviruses outbreaks in French Polynesia Zika virus and blood transfusion: the experience of French Polynesia Zika virus seroprevalence in blood donors from the Northeastern region of Sao Paulo State, Brazil, between 2015 and 2017 Keeping Blood Transfusion Safe From West Nile Virus: American Red Cross Experience Pre-transfusion testing for Ebola virus disease patients in serious communicable infectious diseases hospitals in Tokyo: A cross-sectional study This article is protected by copyright. All rights reserved This article is protected by copyright. All rights reserved