key: cord-0778453-9jd32gxi authors: Yi, Mengqi; Lin, Shixiao; Zhang, Bin; Jin, Haixiao; Ding, Lijian title: Antiviral potential of natural products from marine microbes date: 2020-08-31 journal: Eur J Med Chem DOI: 10.1016/j.ejmech.2020.112790 sha: d8f05075ab5bd052157fb41cce86b4ff46f6a7c8 doc_id: 778453 cord_uid: 9jd32gxi Humans have been suffered from viral infections over the centuries, such as influenza, HSV, and HIV, which have killed millions of people worldwide. However, the availability of effective treatments for infectious diseases remains limited until now, as most of the viral pathogens resisted to many medical treatments. Marine microbes are currently one of the most copious sources of pharmacologically active natural products, which have constantly provided promising antivirus agents. To date, a large number of marine microbial secondary metabolites with antiviral activities have been widely reported. In this review, we have summarized the potential antivirus compounds from marine microorganisms over the last decade. In addition, the structures, bioactivities, and origins of these compounds were discussed as well. (3Z,6Z)-3-(4-hydroxybenzylidene)-6-isobutylidenepiperazine-2,5-dione (9, Figure 5 ), two known 141 analogues, (3Z,6S)-3-benzylidene-6-isobutylpiperazine-2,5-dione (10, Figure 5 ) and albonoursin (11, The Aspergillus sp. SCSIO XWS02F40 derived from a marine sponge resulted in the discovery of two 176 new asteltoxins named asteltoxins E (23, Figure 6 ) and F (24, Figure 6) were collected from different marine sources, including sediments, seawaters, algae, sponges, corals, 395 worms as well as gorgonians ( Figure 2) . Notably, over half of these compounds were isolated from 396 marine sediments (50.6%). 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